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Susd6 sushi domain containing 6 [ Mus musculus (house mouse) ]

Gene ID: 217684, updated on 21-Apr-2024

Summary

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Official Symbol
Susd6provided by MGI
Official Full Name
sushi domain containing 6provided by MGI
Primary source
MGI:MGI:2444661
See related
Ensembl:ENSMUSG00000021133 AllianceGenome:MGI:2444661
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0247; 4933426M11Rik
Summary
Predicted to be involved in cell death and cellular response to DNA damage stimulus. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in genitourinary system; heart; integumental system; lung; and stomach. Orthologous to human SUSD6 (sushi domain containing 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 33.0), colon adult (RPKM 26.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 C3; 12 37.05 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (80837306..80927607)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (80790532..80880833)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family D (with coiled-coil domains) member 1 Neighboring gene predicted gene, 51986 Neighboring gene STARR-seq mESC enhancer starr_32646 Neighboring gene coiled-coil domain containing 177 Neighboring gene STARR-seq mESC enhancer starr_32647 Neighboring gene STARR-seq mESC enhancer starr_32648 Neighboring gene STARR-seq mESC enhancer starr_32649 Neighboring gene STARR-positive B cell enhancer ABC_E5337 Neighboring gene STARR-seq mESC enhancer starr_32653 Neighboring gene STARR-seq mESC enhancer starr_32654 Neighboring gene RIKEN cDNA 1700052I22 gene Neighboring gene predicted gene, 23298

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected]. Polato F, et al. J Natl Cancer Inst, 2014 Apr. PMID 24652652, Free PMC Article
  2. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sushi domain-containing protein 6
Names
drago

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242419.1 → NP_001229348.1  sushi domain-containing protein 6 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001229348.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK030233, AK152500, AK161132, BP762731
    Consensus CDS
    CCDS88361.1
    UniProtKB/TrEMBL
    Q6ZQF4, Q8C0M5
    Related
    ENSMUSP00000151831.2, ENSMUST00000220238.2
    Conserved Domains (2) summary
    cd00033
    Location:63 → 119
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    pfam08333
    Location:41 → 55
    DUF1725; Protein of unknown function (DUF1725)

  2. NM_178682.4 → NP_848797.1  sushi domain-containing protein 6 isoform 2 precursor

    See identical proteins and their annotated locations for NP_848797.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK152500, AK161132, BP762731
    Consensus CDS
    CCDS26016.1
    UniProtKB/Swiss-Prot
    Q8BGE4
    UniProtKB/TrEMBL
    Q3TP03, Q3U749
    Related
    ENSMUSP00000064961.6, ENSMUST00000068519.7
    Conserved Domains (1) summary
    cd00033
    Location:42 → 98
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    80837306..80927607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157311.1 → XP_036013204.1  sushi domain-containing protein 6 isoform X1

    UniProtKB/TrEMBL
    Q6ZQF4, Q8C0M5
    Conserved Domains (2) summary
    cd00033
    Location:63 → 119
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    pfam08333
    Location:41 → 55
    DUF1725; Protein of unknown function (DUF1725)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGE4.1 GenPept UniProtKB/Swiss-Prot:Q8BGE4

Gene LinkOut

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