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Tex264 testis expressed gene 264 ER-phagy receptor [ Mus musculus (house mouse) ]

Gene ID: 21767, updated on 5-Mar-2024

Summary

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Official Symbol
Tex264provided by MGI
Official Full Name
testis expressed gene 264 ER-phagy receptorprovided by MGI
Primary source
MGI:MGI:1096570
See related
Ensembl:ENSMUSG00000040813 AllianceGenome:MGI:1096570
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TEG-264
Summary
Predicted to enable signaling receptor activity. Predicted to be involved in protein-DNA covalent cross-linking repair and reticulophagy. Predicted to act upstream of or within DNA repair and autophagy. Located in autophagosome membrane and endoplasmic reticulum. Orthologous to human TEX264 (testis expressed 264, ER-phagy receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 59.7), kidney adult (RPKM 57.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tex264 in Genome Data Viewer
Location:
9 F1; 9 57.98 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (106535945..106563151, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (106658746..106685952, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 28111 Neighboring gene glutamate receptor, metabotropic 2 Neighboring gene RAD54 like 2 (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_25160 Neighboring gene STARR-seq mESC enhancer starr_25163 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:106723938-106724121 Neighboring gene STARR-positive B cell enhancer ABC_E8313 Neighboring gene DDB1 and CUL4 associated factor 1 Neighboring gene RNA binding motif protein 15B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tex261, a novel gene presumably related but distinct from steroidogenic acute regulatory (StAR) gene, is regulated during the development of germ cells. López-Fernández LA, et al. Biochem Biophys Res Commun, 1998 Jan 26. PMID 9464256
  2. Characterization of genes expressed early in mouse spermatogenesis, isolated from a subtractive cDNA library. López-Fernández LA, et al. Mamm Genome, 1996 Sep. PMID 8703127
  3. A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. García-Frigola C, et al. Brain Res Mol Brain Res, 2004 Mar 30. PMID 15010206
  4. Intrinsically Disordered Protein TEX264 Mediates ER-phagy. Chino H, et al. Mol Cell, 2019 Jun 6. PMID 31006538
  5. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in protein-DNA covalent cross-linking repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein-DNA covalent cross-linking repair ISO
Inferred from Sequence Orthology
more info
  
involved_in reticulophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within reticulophagy ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in reticulophagy ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in autophagosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in autophagosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in autophagosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in replication fork IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in replication fork ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
testis-expressed protein 264 homolog
Names
testis-expressed protein 264

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081654.2 → NP_001075123.1  testis-expressed protein 264 homolog

    See identical proteins and their annotated locations for NP_001075123.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK003113, AK009326, BU700575, BY096844
    Consensus CDS
    CCDS23483.1
    UniProtKB/Swiss-Prot
    E9Q137, Q3TXY2, Q99LS5, Q9D7D9
    Related
    ENSMUSP00000044654.5, ENSMUST00000046735.11
    Conserved Domains (1) summary
    cl01368
    Location:45 → 112
    GyrI-like; GyrI-like small molecule binding domain

  2. NM_001286498.1 → NP_001273427.1  testis-expressed protein 264 homolog

    See identical proteins and their annotated locations for NP_001273427.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK009326, AK159046, BU700575, BY096844, BY331401
    Consensus CDS
    CCDS23483.1
    UniProtKB/Swiss-Prot
    E9Q137, Q3TXY2, Q99LS5, Q9D7D9
    Related
    ENSMUSP00000133194.3, ENSMUST00000169068.8
    Conserved Domains (1) summary
    cl01368
    Location:45 → 112
    GyrI-like; GyrI-like small molecule binding domain

  3. NM_011573.3 → NP_035703.2  testis-expressed protein 264 homolog

    See identical proteins and their annotated locations for NP_035703.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC125188, AK009326, AK159046, BU700575
    Consensus CDS
    CCDS23483.1
    UniProtKB/Swiss-Prot
    E9Q137, Q3TXY2, Q99LS5, Q9D7D9
    Related
    ENSMUSP00000132247.2, ENSMUST00000163441.8
    Conserved Domains (1) summary
    cl01368
    Location:45 → 112
    GyrI-like; GyrI-like small molecule binding domain

RNA

  1. NR_104459.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AK009326, BU700575, BY096844, DV656490

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    106535945..106563151 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q137.1 GenPept UniProtKB/Swiss-Prot:E9Q137

Gene LinkOut

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