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Snx13 sorting nexin 13 [ Mus musculus (house mouse) ]

Gene ID: 217463, updated on 3-Apr-2024

Summary

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Official Symbol
Snx13provided by MGI
Official Full Name
sorting nexin 13provided by MGI
Primary source
MGI:MGI:2661416
See related
Ensembl:ENSMUSG00000020590 AllianceGenome:MGI:2661416
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rgs-px1; mKIAA0713
Summary
Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in intracellular protein transport and positive regulation of GTPase activity. Predicted to act upstream of or within negative regulation of signal transduction and protein transport. Predicted to be located in endosome and membrane. Predicted to be active in early endosome. Is expressed in embryo. Orthologous to human SNX13 (sorting nexin 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 6.5), frontal lobe adult (RPKM 6.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Snx13 in Genome Data Viewer
Location:
12 A3; 12 15.67 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (35097191..35197479)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (35046147..35147480)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40385 Neighboring gene predicted gene, 40386 Neighboring gene predicted gene, 33922 Neighboring gene microRNA 680-3 Neighboring gene STARR-seq mESC enhancer starr_31901 Neighboring gene STARR-seq mESC enhancer starr_31902 Neighboring gene STARR-seq mESC enhancer starr_31903 Neighboring gene STARR-seq mESC enhancer starr_31904 Neighboring gene predicted gene, 26071

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamics. Zheng B, et al. Proc Natl Acad Sci U S A, 2006 Nov 7. PMID 17077144, Free PMC Article
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Snx13-null embryos are defective in nutrient uptake and transport, which may contribute to the other developmental abnormalities observed.
    Title: Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamics.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sorting nexin-13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014973.3 → NP_001014973.3  sorting nexin-13 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122314, AC140376
    Consensus CDS
    CCDS56837.1
    UniProtKB/Swiss-Prot
    Q6PHS6
    Related
    ENSMUSP00000038430.11, ENSMUST00000048519.17

  2. NM_001408815.1 → NP_001395744.1  sorting nexin-13 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122314, AC140376

  3. NM_001408816.1 → NP_001395745.1  sorting nexin-13 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122314, AC140376

  4. NM_001408817.1 → NP_001395746.1  sorting nexin-13 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC122314, AC140376

  5. NM_001408818.1 → NP_001395747.1  sorting nexin-13 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC122314, AC140376

  6. NM_001408819.1 → NP_001395748.1  sorting nexin-13 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC122314, AC140376

  7. NM_001408820.1 → NP_001395749.1  sorting nexin-13 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC122314, AC140376

  8. NM_001408821.1 → NP_001395750.1  sorting nexin-13 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC122314, AC140376

  9. NM_001408822.1 → NP_001395751.1  sorting nexin-13 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC122314, AC140376

  10. NM_001408823.1 → NP_001395752.1  sorting nexin-13 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC122314, AC140376
    UniProtKB/TrEMBL
    E9Q7T4
    Related
    ENSMUSP00000130182.4, ENSMUST00000163677.3

  11. NM_001408824.1 → NP_001395753.1  sorting nexin-13 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC122314, AC140376

  12. NM_001408825.1 → NP_001395754.1  sorting nexin-13 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC122314, AC140376

  13. NM_001408826.1 → NP_001395755.1  sorting nexin-13 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC140376

  14. NM_001408827.1 → NP_001395756.1  sorting nexin-13 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC140376
    Related
    ENSMUST00000222101.2

RNA

  1. NR_176799.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC140376

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    35097191..35197479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515064.4 → XP_006515127.1  sorting nexin-13 isoform X4

    UniProtKB/TrEMBL
    Q3V091
    Conserved Domains (4) summary
    cd06873
    Location:354 → 484
    PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
    cd08719
    Location:174 → 308
    RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
    pfam08628
    Location:600 → 708
    Nexin_C; Sorting nexin C terminal
    cl02564
    Location:13 → 81
    PXA; PXA domain

  2. XM_036157306.1 → XP_036013199.1  sorting nexin-13 isoform X6

    UniProtKB/TrEMBL
    Q3V091
    Conserved Domains (4) summary
    cd06873
    Location:309 → 439
    PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
    cd08719
    Location:129 → 263
    RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
    pfam08628
    Location:555 → 663
    Nexin_C; Sorting nexin C terminal
    cl02564
    Location:3 → 36
    PXA; PXA domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PHS6.1 GenPept UniProtKB/Swiss-Prot:Q6PHS6

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