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Trappc12 trafficking protein particle complex 12 [ Mus musculus (house mouse) ]

Gene ID: 217449, updated on 5-Mar-2024

Summary

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Official Symbol
Trappc12provided by MGI
Official Full Name
trafficking protein particle complex 12provided by MGI
Primary source
MGI:MGI:2445089
See related
Ensembl:ENSMUSG00000020628 AllianceGenome:MGI:2445089
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ttc15; CGI-87; D930014A20Rik
Summary
Predicted to be involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of protein localization to kinetochore; and regulation of kinetochore assembly. Predicted to act upstream of or within vesicle-mediated transport. Predicted to be located in kinetochore and nucleoplasm. Predicted to be part of TRAPP complex. Predicted to be active in Golgi apparatus. Predicted to colocalize with endoplasmic reticulum-Golgi intermediate compartment and perinuclear region of cytoplasm. Orthologous to human TRAPPC12 (trafficking protein particle complex subunit 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 7.2), bladder adult (RPKM 7.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 A2; 12 11.1 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (28740619..28801746, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (28690620..28750485, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ribonuclease H1 Neighboring gene microRNA 6937 Neighboring gene acireductone dioxygenase 1 Neighboring gene STARR-seq mESC enhancer starr_31820 Neighboring gene STARR-positive B cell enhancer ABC_E9386 Neighboring gene predicted gene, 31269 Neighboring gene EARP complex and GARP complex interacting protein 1 Neighboring gene predicted gene, 46345 Neighboring gene STARR-seq mESC enhancer starr_31822 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:29519262-29519445 Neighboring gene STARR-seq mESC enhancer starr_31825 Neighboring gene STARR-seq mESC enhancer starr_31826 Neighboring gene predicted gene, 31508

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TRAPP Complexes in Secretion and Autophagy. Kim JJ, et al. Front Cell Dev Biol, 2016. PMID 27066478, Free PMC Article
  2. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in COPII vesicle coating NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to kinetochore ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of kinetochore assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle tethering NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of TRAPP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TRAPP complex ISO
Inferred from Sequence Orthology
more info
  
part_of TRAPPIII protein complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
colocalizes_with endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
trafficking protein particle complex subunit 12
Names
TPR repeat protein 15
tetratricopeptide repeat domain 15
tetratricopeptide repeat protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161410.2 → NP_001154882.1  trafficking protein particle complex subunit 12 isoform 1

    See identical proteins and their annotated locations for NP_001154882.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC136986
    Consensus CDS
    CCDS25854.1
    UniProtKB/Swiss-Prot
    E9QLQ6, Q8BX27, Q8K2L8
    UniProtKB/TrEMBL
    Q3UGE1
    Related
    ENSMUSP00000127752.3, ENSMUST00000168129.10
    Conserved Domains (5) summary
    TIGR02795
    Location:600 → 670
    tol_pal_ybgF; tol-pal system protein YbgF
    PHA03307
    Location:1 → 380
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00006
    Location:608 → 635
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:644 → 711
    TPR_12; Tetratricopeptide repeat
    pfam15782
    Location:214 → 332
    GREB1; Gene regulated by oestrogen in breast cancer

  2. NM_001161411.2 → NP_001154883.1  trafficking protein particle complex subunit 12 isoform 2

    See identical proteins and their annotated locations for NP_001154883.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR compared to variant 1. This results in a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC136986
    Consensus CDS
    CCDS49040.1
    UniProtKB/TrEMBL
    Q8BUB5, Q8C0C3
    Related
    ENSMUSP00000132009.2, ENSMUST00000170994.3
    Conserved Domains (1) summary
    pfam15782
    Location:214 → 332
    GREB1; Gene regulated by oestrogen in breast cancer

  3. NM_001377005.1 → NP_001363934.1  trafficking protein particle complex subunit 12 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC136986
    UniProtKB/TrEMBL
    Q8BUB5, Q8C0C3
    Conserved Domains (1) summary
    pfam15782
    Location:214 → 332
    GREB1; Gene regulated by oestrogen in breast cancer

  4. NM_001377006.1 → NP_001363935.1  trafficking protein particle complex subunit 12 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC136986
    UniProtKB/TrEMBL
    Q3UGE1
    Conserved Domains (5) summary
    TIGR02795
    Location:600 → 671
    tol_pal_ybgF; tol-pal system protein YbgF
    PHA03307
    Location:1 → 380
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00006
    Location:608 → 635
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:644 → 712
    TPR_12; Tetratricopeptide repeat
    pfam15782
    Location:214 → 332
    GREB1; Gene regulated by oestrogen in breast cancer

  5. NM_001377007.1 → NP_001363936.1  trafficking protein particle complex subunit 12 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC136986
    UniProtKB/Swiss-Prot
    E9QLQ6, Q8BX27, Q8K2L8
    UniProtKB/TrEMBL
    Q3UGE1
    Conserved Domains (5) summary
    TIGR02795
    Location:600 → 670
    tol_pal_ybgF; tol-pal system protein YbgF
    PHA03307
    Location:1 → 380
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00006
    Location:608 → 635
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:644 → 711
    TPR_12; Tetratricopeptide repeat
    pfam15782
    Location:214 → 332
    GREB1; Gene regulated by oestrogen in breast cancer

  6. NM_178811.5 → NP_848926.3  trafficking protein particle complex subunit 12 isoform 1

    See identical proteins and their annotated locations for NP_848926.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC136986
    Consensus CDS
    CCDS25854.1
    UniProtKB/Swiss-Prot
    E9QLQ6, Q8BX27, Q8K2L8
    UniProtKB/TrEMBL
    Q3UGE1
    Related
    ENSMUSP00000020954.9, ENSMUST00000020954.15
    Conserved Domains (5) summary
    TIGR02795
    Location:600 → 670
    tol_pal_ybgF; tol-pal system protein YbgF
    PHA03307
    Location:1 → 380
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00006
    Location:608 → 635
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:644 → 711
    TPR_12; Tetratricopeptide repeat
    pfam15782
    Location:214 → 332
    GREB1; Gene regulated by oestrogen in breast cancer

RNA

  1. NR_165042.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC136986

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    28740619..28801746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515059.3 → XP_006515122.1  trafficking protein particle complex subunit 12 isoform X1

    See identical proteins and their annotated locations for XP_006515122.1

    UniProtKB/TrEMBL
    Q3UGE1
    Conserved Domains (5) summary
    TIGR02795
    Location:600 → 671
    tol_pal_ybgF; tol-pal system protein YbgF
    PHA03307
    Location:1 → 380
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00006
    Location:608 → 635
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:644 → 712
    TPR_12; Tetratricopeptide repeat
    pfam15782
    Location:214 → 332
    GREB1; Gene regulated by oestrogen in breast cancer

  2. XM_006515057.3 → XP_006515120.1  trafficking protein particle complex subunit 12 isoform X1

    See identical proteins and their annotated locations for XP_006515120.1

    UniProtKB/TrEMBL
    Q3UGE1
    Conserved Domains (5) summary
    TIGR02795
    Location:600 → 671
    tol_pal_ybgF; tol-pal system protein YbgF
    PHA03307
    Location:1 → 380
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00006
    Location:608 → 635
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:644 → 712
    TPR_12; Tetratricopeptide repeat
    pfam15782
    Location:214 → 332
    GREB1; Gene regulated by oestrogen in breast cancer

  3. XM_006515061.5 → XP_006515124.1  trafficking protein particle complex subunit 12 isoform X2

    UniProtKB/TrEMBL
    Q3TB00
    Conserved Domains (1) summary
    pfam15782
    Location:214 → 332
    GREB1; Gene regulated by oestrogen in breast cancer

RNA

  1. XR_004937486.1 RNA Sequence

  2. XR_003950032.2 RNA Sequence

  3. XR_003950034.2 RNA Sequence

  4. XR_001780444.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2L8.2 GenPept UniProtKB/Swiss-Prot:Q8K2L8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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