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Slc66a3 solute carrier family 66 member 3 [ Mus musculus (house mouse) ]

Gene ID: 217430, updated on 5-Mar-2024

Summary

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Official Symbol
Slc66a3provided by MGI
Official Full Name
solute carrier family 66 member 3provided by MGI
Primary source
MGI:MGI:2444067
See related
Ensembl:ENSMUSG00000045679 AllianceGenome:MGI:2444067
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pqlc3; E030024M05Rik
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in brain; lower jaw molar; olfactory epithelium; and upper jaw molar. Orthologous to human SLC66A3 (solute carrier family 66 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 7.3), bladder adult (RPKM 5.8) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 A1.1; 12 8.04 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (17038649..17050385, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (16988648..17000386, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31647 Neighboring gene predicted gene, 36495 Neighboring gene STARR-seq mESC enhancer starr_31650 Neighboring gene Rho-associated coiled-coil containing protein kinase 2 Neighboring gene predicted gene, 22303 Neighboring gene STARR-seq mESC enhancer starr_31651 Neighboring gene RIKEN cDNA 2410004P03 gene Neighboring gene STARR-positive B cell enhancer ABC_E7121 Neighboring gene STARR-positive B cell enhancer ABC_E11504 Neighboring gene STARR-seq mESC enhancer starr_31652 Neighboring gene STARR-seq mESC enhancer starr_31653 Neighboring gene potassium voltage-gated channel, subfamily F, member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of novel radiation-induced p53-dependent transcripts extensively regulated during mouse brain development. Quintens R, et al. Biol Open, 2015 Feb 13. PMID 25681390, Free PMC Article
  2. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 66 member 3
Names
PQ loop repeat containing 3
PQ-loop repeat-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172574.2 → NP_766162.2  solute carrier family 66 member 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_766162.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC155305, AK053171, AK138680, AK150094, BY236955
    Consensus CDS
    CCDS25824.1
    UniProtKB/Swiss-Prot
    Q8C6U2, Q8QZS7
    Related
    ENSMUSP00000054462.5, ENSMUST00000054536.11
    Conserved Domains (1) summary
    pfam04193
    Location:5 → 53
    PQ-loop; PQ loop repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    17038649..17050385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515056.5 → XP_006515119.1  solute carrier family 66 member 3 isoform X1

    UniProtKB/TrEMBL
    A0A1Y7VLY9, Q3UU83
    Related
    ENSMUSP00000152715.2, ENSMUST00000222203.2
    Conserved Domains (1) summary
    pfam04193
    Location:5 → 53
    PQ-loop; PQ loop repeat

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001161111.1: Suppressed sequence

    Description
    NM_001161111.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C6U2.1 GenPept UniProtKB/Swiss-Prot:Q8C6U2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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