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Qrich2 glutamine rich 2 [ Mus musculus (house mouse) ]

Gene ID: 217341, updated on 5-Mar-2024

Summary

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Official Symbol
Qrich2provided by MGI
Official Full Name
glutamine rich 2provided by MGI
Primary source
MGI:MGI:2684912
See related
Ensembl:ENSMUSG00000070331 AllianceGenome:MGI:2684912
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm66
Summary
Involved in cell projection assembly; flagellated sperm motility; and negative regulation of ubiquitin-dependent protein catabolic process. Located in cytoplasm; nucleus; and sperm flagellum. Human ortholog(s) of this gene implicated in spermatogenic failure 35. Orthologous to human QRICH2 (glutamine rich 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 124.1) See more
Orthologs
human all
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Genomic context

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See Qrich2 in Genome Data Viewer
Location:
11 E2; 11 81.3 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116332149..116357092, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116441323..116466266, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 157 Neighboring gene ribosomal protein S11, pseudogene 2 Neighboring gene STARR-positive B cell enhancer mm9_chr11:116255636-116255937 Neighboring gene STARR-positive B cell enhancer ABC_E9382 Neighboring gene STARR-positive B cell enhancer ABC_E8472 Neighboring gene STARR-positive B cell enhancer ABC_E5300 Neighboring gene STARR-positive B cell enhancer ABC_E10733 Neighboring gene STARR-seq mESC enhancer starr_31202 Neighboring gene STARR-seq mESC enhancer starr_31205 Neighboring gene UBA-like domain containing 2 Neighboring gene phosphoribosyl pyrophosphate synthetase-associated protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E7101 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:116351868-116352051 Neighboring gene ribosomal protein L36, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss-of-function missense variant of AKAP4 induced male infertility through reduced interaction with QRICH2 during sperm flagella development. Zhang G, et al. Hum Mol Genet, 2021 Dec 27. PMID 34415320
  2. Loss-of-function mutations in QRICH2 cause male infertility with multiple morphological abnormalities of the sperm flagella. Shen Y, et al. Nat Commun, 2019 Jan 25. PMID 30683861, Free PMC Article
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss-of-function missense variant of AKAP4 induced male infertility through reduced interaction with QRICH2 during sperm flagella development.
    Title: Loss-of-function missense variant of AKAP4 induced male infertility through reduced interaction with QRICH2 during sperm flagella development.
  2. The findings strongly suggest that the genetic mutations of QRICH2 can lead to male infertility with multiple morphological abnormalities of the flagella, and that QRICH2 is essential for sperm flagellar formation.
    Title: Loss-of-function mutations in QRICH2 cause male infertility with multiple morphological abnormalities of the sperm flagella.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell projection assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell projection assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in flagellated sperm motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in sperm flagellum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glutamine-rich protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033267.3 → NP_001028439.2  glutamine-rich protein 2

    Status: VALIDATED

    Source sequence(s)
    AL645851, AL645861
    Consensus CDS
    CCDS25667.1
    UniProtKB/TrEMBL
    A0A140LIY9
    Related
    ENSMUSP00000147009.2, ENSMUST00000208602.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    116332149..116357092 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533105.4 → XP_006533168.2  glutamine-rich protein 2 isoform X7

    Conserved Domains (4) summary
    PHA03378
    Location:1135 → 1404
    PHA03378; EBNA-3B; Provisional
    COG0419
    Location:1517 → 1912
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    pfam03157
    Location:512 → 1111
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam16043
    Location:1763 → 1942
    DUF4795; Domain of unknown function (DUF4795)

  2. XM_011248958.3 → XP_011247260.1  glutamine-rich protein 2 isoform X6

    Conserved Domains (4) summary
    PHA03378
    Location:1173 → 1442
    PHA03378; EBNA-3B; Provisional
    COG0419
    Location:1555 → 1950
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    pfam03157
    Location:550 → 1149
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam16043
    Location:1801 → 1980
    DUF4795; Domain of unknown function (DUF4795)

  3. XM_011248957.3 → XP_011247259.1  glutamine-rich protein 2 isoform X5

    Conserved Domains (4) summary
    PHA03378
    Location:1195 → 1464
    PHA03378; EBNA-3B; Provisional
    COG0419
    Location:1577 → 1972
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    pfam03157
    Location:572 → 1171
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam16043
    Location:1823 → 2002
    DUF4795; Domain of unknown function (DUF4795)

  4. XM_011248956.3 → XP_011247258.1  glutamine-rich protein 2 isoform X4

    See identical proteins and their annotated locations for XP_011247258.1

    Conserved Domains (5) summary
    PHA03378
    Location:1205 → 1474
    PHA03378; EBNA-3B; Provisional
    COG0419
    Location:1587 → 1982
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    TIGR02169
    Location:95 → 237
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam03157
    Location:594 → 1181
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam16043
    Location:1833 → 2012
    DUF4795; Domain of unknown function (DUF4795)

  5. XM_011248955.3 → XP_011247257.1  glutamine-rich protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011247257.1

    Conserved Domains (5) summary
    PHA03378
    Location:1205 → 1474
    PHA03378; EBNA-3B; Provisional
    COG0419
    Location:1587 → 1982
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    TIGR02169
    Location:95 → 237
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam03157
    Location:594 → 1181
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam16043
    Location:1833 → 2012
    DUF4795; Domain of unknown function (DUF4795)

  6. XM_017314492.2 → XP_017169981.1  glutamine-rich protein 2 isoform X3

    Conserved Domains (5) summary
    PHA03378
    Location:1205 → 1474
    PHA03378; EBNA-3B; Provisional
    COG0419
    Location:1587 → 1982
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    TIGR02169
    Location:95 → 237
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam03157
    Location:592 → 1213
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam16043
    Location:1833 → 2012
    DUF4795; Domain of unknown function (DUF4795)

  7. XM_011248959.2 → XP_011247261.1  glutamine-rich protein 2 isoform X9

    Conserved Domains (4) summary
    PHA03378
    Location:922 → 1191
    PHA03378; EBNA-3B; Provisional
    COG0419
    Location:1304 → 1699
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    pfam03157
    Location:299 → 887
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam16043
    Location:1550 → 1729
    DUF4795; Domain of unknown function (DUF4795)

  8. XM_017314493.2 → XP_017169982.1  glutamine-rich protein 2 isoform X8

    Conserved Domains (5) summary
    PHA03378
    Location:1215 → 1484
    PHA03378; EBNA-3B; Provisional
    COG0419
    Location:1597 → 1992
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    TIGR02169
    Location:95 → 237
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam03157
    Location:592 → 1191
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam16043
    Location:1843 → 2022
    DUF4795; Domain of unknown function (DUF4795)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3V2A7.1 GenPept UniProtKB/Swiss-Prot:Q3V2A7

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