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Rnf157 ring finger protein 157 [ Mus musculus (house mouse) ]

Gene ID: 217340, updated on 21-Apr-2024

Summary

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Official Symbol
Rnf157provided by MGI
Official Full Name
ring finger protein 157provided by MGI
Primary source
MGI:MGI:2442484
See related
Ensembl:ENSMUSG00000052949 AllianceGenome:MGI:2442484
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1917; 2610036E23Rik; A130073L17Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of signal transduction; positive regulation of dendrite extension; and protein autoubiquitination. Predicted to be located in cell body. Predicted to be active in early endosome; nucleus; and plasma membrane. Is expressed in future spinal cord. Orthologous to human RNF157 (ring finger protein 157). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 39.1), cortex adult (RPKM 38.6) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E2; 11 81.17 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116227179..116303859, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116336345..116413391, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26730 Neighboring gene STARR-seq mESC enhancer starr_31197 Neighboring gene STARR-seq mESC enhancer starr_31198 Neighboring gene forkhead box J1 Neighboring gene STARR-positive B cell enhancer ABC_E5299 Neighboring gene ribosomal protein S11, pseudogene 2 Neighboring gene STARR-positive B cell enhancer mm9_chr11:116255636-116255937 Neighboring gene STARR-positive B cell enhancer ABC_E9382 Neighboring gene STARR-positive B cell enhancer ABC_E8472 Neighboring gene STARR-positive B cell enhancer ABC_E5300 Neighboring gene STARR-positive B cell enhancer ABC_E10733 Neighboring gene STARR-seq mESC enhancer starr_31202 Neighboring gene STARR-seq mESC enhancer starr_31205 Neighboring gene UBA-like domain containing 2 Neighboring gene glutamine rich 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A Membrane-Tethered Ubiquitination Pathway Regulates Hedgehog Signaling and Heart Development. Kong JH, et al. Dev Cell, 2020 Nov 23. PMID 32966817, Free PMC Article
  2. Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157. Matz A, et al. Cell Death Differ, 2015 Apr. PMID 25342469, Free PMC Article
  3. Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord. Masuda T, et al. Brain Res, 2009 Jan 16. PMID 19026994
  4. Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Georgas K, et al. Dev Biol, 2009 Aug 15. PMID 19501082
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNF157 attenuates CD4[+] T cell-mediated autoimmune response by promoting HDAC1 ubiquitination and degradation.
    Title: RNF157 attenuates CD4(+) T cell-mediated autoimmune response by promoting HDAC1 ubiquitination and degradation.
  2. RNF157 has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical.
    Title: Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin ligase Rnf157
Names
RING-type E3 ubiquitin transferase Rnf157
NP_001392066.1
NP_001392067.1
NP_001392068.1
NP_001392069.1
NP_001392070.1
NP_001392071.1
NP_001392072.1
NP_001392073.1
NP_001392074.1
NP_081534.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001405137.1 → NP_001392066.1  E3 ubiquitin ligase Rnf157 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645861

  2. NM_001405138.1 → NP_001392067.1  E3 ubiquitin ligase Rnf157 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL645861

  3. NM_001405139.1 → NP_001392068.1  E3 ubiquitin ligase Rnf157 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL645861

  4. NM_001405140.1 → NP_001392069.1  E3 ubiquitin ligase Rnf157 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL645861

  5. NM_001405141.1 → NP_001392070.1  E3 ubiquitin ligase Rnf157 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL645861

  6. NM_001405142.1 → NP_001392071.1  E3 ubiquitin ligase Rnf157 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL645861

  7. NM_001405143.1 → NP_001392072.1  E3 ubiquitin ligase Rnf157 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL645861

  8. NM_001405144.1 → NP_001392073.1  E3 ubiquitin ligase Rnf157 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL645861

  9. NM_001405145.1 → NP_001392074.1  E3 ubiquitin ligase Rnf157 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL645861

  10. NM_027258.2 → NP_081534.1  E3 ubiquitin ligase Rnf157 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL645861
    Consensus CDS
    CCDS48984.1
    UniProtKB/TrEMBL
    A2AAN9, A2AAP0
    Related
    ENSMUSP00000097776.4, ENSMUST00000100202.10
    Conserved Domains (1) summary
    pfam13920
    Location:276 → 318
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    116227179..116303859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TEL6.2 GenPept UniProtKB/Swiss-Prot:Q3TEL6

Gene LinkOut

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