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Unk unkempt family zinc finger [ Mus musculus (house mouse) ]

Gene ID: 217331, updated on 11-Apr-2024

Summary

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Official Symbol
Unkprovided by MGI
Official Full Name
unkempt family zinc fingerprovided by MGI
Primary source
MGI:MGI:2442456
See related
Ensembl:ENSMUSG00000020770 AllianceGenome:MGI:2442456
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Unkh; Zc3h5; Zc3hdc5; mKIAA1753; B230379M23Rik
Summary
Enables mRNA CDS binding activity and polysome binding activity. Acts upstream of or within cell morphogenesis involved in neuron differentiation; in utero embryonic development; and neuron migration. Predicted to be located in cytoplasm. Predicted to be part of polysome. Is expressed in central nervous system; early conceptus; future brain; oocyte; and retina nuclear layer. Orthologous to human UNK (unk zinc finger). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 15.6), limb E14.5 (RPKM 14.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E2; 11 80.91 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115921117..115952040)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116028616..116061214)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene integrin beta 4 Neighboring gene RIKEN cDNA B230344G16 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115873522-115873709 Neighboring gene galactokinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E306 Neighboring gene STARR-seq mESC enhancer starr_31191 Neighboring gene H3.3 histone B Neighboring gene STARR-seq mESC enhancer starr_31192 Neighboring gene predicted gene, 38482 Neighboring gene unc-13 homolog D Neighboring gene STARR-positive B cell enhancer ABC_E10732 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115939592-115939779 Neighboring gene STARR-positive B cell enhancer ABC_E381 Neighboring gene WW domain binding protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Recognition of distinct RNA motifs by the clustered CCCH zinc fingers of neuronal protein Unkempt. Murn J, et al. Nat Struct Mol Biol, 2016 Jan. PMID 26641712, Free PMC Article
  2. Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis. Baskaran P, et al. J Biol Chem, 2023 Jan. PMID 36509146, Free PMC Article
  3. The embryonically active gene, unkempt, of Drosophila encodes a Cys3His finger protein. Mohler J, et al. Genetics, 1992 Jun. PMID 1339381, Free PMC Article
  4. Hectd1 is required for development of the junctional zone of the placenta. Sarkar AA, et al. Dev Biol, 2014 Aug 15. PMID 24855001, Free PMC Article
  5. The zinc finger/RING domain protein Unkempt regulates cognitive flexibility. Vinsland E, et al. Sci Rep, 2021 Aug 11. PMID 34381067, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis.
    Title: Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis.
  2. The authors determined the X-ray crystal structure of mouse Unkempt and show that its six CCCH zinc fingers (ZnFs) form two compact clusters, ZnF1-3 and ZnF4-6, that recognize distinct trinucleotide RNA substrates.
    Title: Recognition of distinct RNA motifs by the clustered CCCH zinc fingers of neuronal protein Unkempt.
  3. Depletion of Unkempt in mouse embryos disrupts the shape of migrating neurons, while ectopic expression confers neuronal-like morphology to cells of different nonneuronal lineages.
    Title: Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA CDS binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA CDS binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA CDS binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell morphogenesis involved in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis involved in neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RING finger protein unkempt homolog
Names
unkempt homolog
zinc finger CCCH domain-containing protein 5
zinc finger CCCH type containing 5
zinc finger CCCH type domain containing 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286006.1 → NP_001272935.1  RING finger protein unkempt homolog isoform 2

    See identical proteins and their annotated locations for NP_001272935.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK134361, BB619163, BC033048
    Consensus CDS
    CCDS70351.1
    UniProtKB/TrEMBL
    Q3UYU7
    Related
    ENSMUSP00000102060.2, ENSMUST00000106452.2
    Conserved Domains (3) summary
    pfam00642
    Location:294 → 318
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam05384
    Location:633 → 706
    DegS; Sensor protein DegS
    pfam13920
    Location:752 → 788
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  2. NM_172569.4 → NP_766157.1  RING finger protein unkempt homolog isoform 1

    See identical proteins and their annotated locations for NP_766157.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK046395, BB619163, BC033048
    Consensus CDS
    CCDS25655.1
    UniProtKB/Swiss-Prot
    A2A853, Q8BL48, Q8BVI6, Q99JZ8, Q99LL9
    Related
    ENSMUSP00000021116.6, ENSMUST00000021116.12
    Conserved Domains (3) summary
    pfam00642
    Location:294 → 318
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam05384
    Location:646 → 719
    DegS; Sensor protein DegS
    pfam13920
    Location:765 → 801
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    115921117..115952040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533088.5 → XP_006533151.1  RING finger protein unkempt homolog isoform X1

    Conserved Domains (6) summary
    PHA03307
    Location:300 → 571
    PHA03307; transcriptional regulator ICP4; Provisional
    COG4372
    Location:625 → 730
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    TIGR02680
    Location:485 → 733
    TIGR02680; TIGR02680 family protein
    cd16614
    Location:740 → 773
    RING-HC_UNK_like; RING finger, HC subclass, found in RING finger protein unkempt (UNK), unkempt-like (UNKL), and similar proteins
    pfam00642
    Location:294 → 318
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam18384
    Location:34 → 69
    zf_CCCH_5; Unkempt Zinc finger domain 1 (Znf1)

  2. XM_030245897.2 → XP_030101757.1  RING finger protein unkempt homolog isoform X3

    Conserved Domains (5) summary
    smart00356
    Location:47 → 71
    ZnF_C3H1; zinc finger
    COG4372
    Location:457 → 562
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    TIGR02680
    Location:317 → 565
    TIGR02680; TIGR02680 family protein
    cd16614
    Location:572 → 605
    RING-HC_UNK_like; RING finger, HC subclass, found in RING finger protein unkempt (UNK), unkempt-like (UNKL), and similar proteins
    pfam00642
    Location:126 → 150
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

  3. XM_006533089.4 → XP_006533152.1  RING finger protein unkempt homolog isoform X2

    Related
    ENSMUST00000150759.8
    Conserved Domains (4) summary
    smart00356
    Location:47 → 71
    ZnF_C3H1; zinc finger
    PRK11448
    Location:452 → 583
    hsdR; type I restriction enzyme EcoKI subunit R; Provisional
    cd16614
    Location:600 → 633
    RING-HC_UNK_like; RING finger, HC subclass, found in RING finger protein unkempt (UNK), unkempt-like (UNKL), and similar proteins
    pfam00642
    Location:126 → 150
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

  4. XM_036156606.1 → XP_036012499.1  RING finger protein unkempt homolog isoform X5

    Conserved Domains (2) summary
    PRK11448
    Location:306 → 437
    hsdR; type I restriction enzyme EcoKI subunit R; Provisional
    cd16614
    Location:454 → 487
    RING-HC_UNK_like; RING finger, HC subclass, found in RING finger protein unkempt (UNK), unkempt-like (UNKL), and similar proteins

  5. XM_036156605.1 → XP_036012498.1  RING finger protein unkempt homolog isoform X4

    UniProtKB/TrEMBL
    Q3V2Z5
    Conserved Domains (2) summary
    PRK11448
    Location:319 → 450
    hsdR; type I restriction enzyme EcoKI subunit R; Provisional
    cd16614
    Location:467 → 500
    RING-HC_UNK_like; RING finger, HC subclass, found in RING finger protein unkempt (UNK), unkempt-like (UNKL), and similar proteins

  6. XM_017314490.3 → XP_017169979.1  RING finger protein unkempt homolog isoform X2

    Conserved Domains (4) summary
    smart00356
    Location:47 → 71
    ZnF_C3H1; zinc finger
    PRK11448
    Location:452 → 583
    hsdR; type I restriction enzyme EcoKI subunit R; Provisional
    cd16614
    Location:600 → 633
    RING-HC_UNK_like; RING finger, HC subclass, found in RING finger protein unkempt (UNK), unkempt-like (UNKL), and similar proteins
    pfam00642
    Location:126 → 150
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

RNA

  1. XR_001779962.3 RNA Sequence

  2. XR_001779963.3 RNA Sequence

  3. XR_001779964.3 RNA Sequence

  4. XR_003949402.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BL48.1 GenPept UniProtKB/Swiss-Prot:Q8BL48

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