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Slc16a5 solute carrier family 16 (monocarboxylic acid transporters), member 5 [ Mus musculus (house mouse) ]

Gene ID: 217316, updated on 11-Apr-2024

Summary

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Official Symbol
Slc16a5provided by MGI
Official Full Name
solute carrier family 16 (monocarboxylic acid transporters), member 5provided by MGI
Primary source
MGI:MGI:2443515
See related
Ensembl:ENSMUSG00000045775 AllianceGenome:MGI:2443515
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MCT5; MCT 5; MCT 6; A130015N09Rik
Summary
Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human SLC16A5 (solute carrier family 16 member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 51.1), duodenum adult (RPKM 26.1) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Slc16a5 in Genome Data Viewer
Location:
11 E2; 11 80.84 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115353231..115365224)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115462405..115474398)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1435 Neighboring gene potassium channel tetramerisation domain containing 2 Neighboring gene tripartite motif-containing 80 Neighboring gene microRNA 3968 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115323680-115323881 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115324075-115324262 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115324966-115325149 Neighboring gene predicted gene 11695 Neighboring gene STARR-positive B cell enhancer ABC_E5298 Neighboring gene armadillo repeat containing 7 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115353318-115353427 Neighboring gene ribosomal protein L39 pseudogene Neighboring gene 5',3'-nucleotidase, cytosolic

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization and Proteomic-Transcriptomic Investigation of Monocarboxylate Transporter 6 Knockout Mice: Evidence of a Potential Role in Glucose and Lipid Metabolism. Jones RS, et al. Mol Pharmacol, 2019 Sep. PMID 31436537, Free PMC Article
  2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (4)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monocarboxylic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
monocarboxylate transporter 6
Names
monocarboxylate transporter 5
solute carrier family 16 member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080934.1 → NP_001074403.1  monocarboxylate transporter 6 isoform 1

    See identical proteins and their annotated locations for NP_001074403.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL645470
    Consensus CDS
    CCDS36373.1
    UniProtKB/Swiss-Prot
    A2A9X8, A2A9X9, A2A9Y0, G5E8K6
    Related
    ENSMUSP00000090102.6, ENSMUST00000092445.12
    Conserved Domains (2) summary
    cd06174
    Location:32 → 413
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:8 → 461
    2A0113; monocarboxylate transporter 1

  2. NM_001359606.1 → NP_001346535.1  monocarboxylate transporter 6 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK037416, AK079757, BC052932
    Conserved Domains (1) summary
    TIGR00892
    Location:1 → 326
    2A0113; monocarboxylate transporter 1

  3. NM_001359608.1 → NP_001346537.1  monocarboxylate transporter 6 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two coding exons, compared to variant 1. It encodes isoform 3, which lacks a large internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AK079757, BC052932
    Consensus CDS
    CCDS88283.1
    UniProtKB/TrEMBL
    A0A0A0MQC4
    Related
    ENSMUSP00000102142.4, ENSMUST00000106532.4
    Conserved Domains (1) summary
    cl26868
    Location:8 → 94
    2A0111; oxalate/formate antiporter family transporter

  4. NM_001359609.1 → NP_001346538.1  monocarboxylate transporter 6 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the use of an alternate promoter compared to variant 1. It differs in the 5' UTR, uses a downstream start codon and lacks a coding exon, compared to variant 1. It encodes isoform 4, which is shorter than isoform 1.
    Source sequence(s)
    BC052932
    Related
    ENSMUST00000133636.8
    Conserved Domains (1) summary
    cl26868
    Location:1 → 34
    2A0111; oxalate/formate antiporter family transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    115353231..115365224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245893.1 → XP_030101753.1  monocarboxylate transporter 6 isoform X3

    Conserved Domains (2) summary
    TIGR00892
    Location:115 → 190
    2A0113; monocarboxylate transporter 1
    cl28910
    Location:13 → 116
    MFS; Major Facilitator Superfamily

  2. XM_006533082.4 → XP_006533145.1  monocarboxylate transporter 6 isoform X2

    See identical proteins and their annotated locations for XP_006533145.1

    Conserved Domains (1) summary
    TIGR00892
    Location:1 → 326
    2A0113; monocarboxylate transporter 1

  3. XM_006533080.4 → XP_006533143.1  monocarboxylate transporter 6 isoform X1

    Conserved Domains (1) summary
    TIGR00892
    Location:1 → 379
    2A0113; monocarboxylate transporter 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5E8K6.1 GenPept UniProtKB/Swiss-Prot:G5E8K6

Gene LinkOut

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