Cd300ld CD300 molecule like family member d [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd300ldprovided by MGI
Official Full Name: CD300 molecule like family member dprovided by MGI
Primary source: MGI:MGI:2442358
See related: Ensembl:ENSMUSG00000034641 AllianceGenome:MGI:2442358
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CLM5; LMIR4; clm-5; MAIR-IV; Cd300ld1; 4732429D16Rik
Summary: Enables virus receptor activity. Acts upstream of or within regulation of interleukin-6 production and regulation of tumor necrosis factor production. Located in plasma membrane. Orthologous to human CD300LD (CD300 molecule like family member d). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in mammary gland adult (RPKM 2.7), spleen adult (RPKM 2.3) and 19 other tissues See more
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Genomic context

Location:: 11 E2; 11 80.56 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (114873269..114880712, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (114982443..114989886, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD300ld on neutrophils is required for tumour-driven immune suppression.
Title: CD300ld on neutrophils is required for tumour-driven immune suppression.
Our results indicate that direct interaction of MNV with two cell-surface molecules, CD300lf and CD300ld, dictates permissive noroviral infection.
Title: Functional receptor molecules CD300lf and CD300ld within the CD300 family enable murine noroviruses to infect cells.
Data show that LMIR7/CLM-3 shares similarities with LMIR4/CLM-5, although they are differentially regulated in their distribution, expression, and function.
Title: Characterization of leukocyte mono-immunoglobulin-like receptor 7 (LMIR7)/CLM-3 as an activating receptor: its similarities to and differences from LMIR4/CLM-5.
MAIR-IV may regulate activation of neutrophils and play an important role for innate immunity.
Title: Activation of neutrophils by a novel triggering immunoglobulin-like receptor MAIR-IV.
the innate immune system is at least in part regulated by the qualitative and quantitative balance of the paired receptors LMIR3 and LMIR4
Title: Functional analysis of activating receptor LMIR4 as a counterpart of inhibitory receptor LMIR3.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables virus receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CMRF35-like molecule 5

Names: CD300 antigen like family member D; MAIR-4; leukocyte mono-Ig-like receptor 4; myeloid-associated immunoglobulin (Ig)-like receptor IV; myeloid-associated immunoglobulin-like receptor 4; novel immunoglobulin V-set protein (Clm5)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145437.2 → NP_663412.1 CMRF35-like molecule 5 precursor

See identical proteins and their annotated locations for NP_663412.1

Status: PROVISIONAL

Source sequence(s)

AL607025

Consensus CDS

CCDS25615.1

UniProtKB/Swiss-Prot

Q8BRU3, Q8VCH2

UniProtKB/TrEMBL

A0A1C9ZWJ7

Related

ENSMUSP00000047022.3, ENSMUST00000045075.3

Conserved Domains (2) summary

cd05716
Location:27 → 124

Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)

smart00410
Location:25 → 125

IG_like; Immunoglobulin like