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Ace3 angiotensin I converting enzyme 3 [ Mus musculus (house mouse) ]

Gene ID: 217246, updated on 11-Apr-2024

Summary

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Official Symbol
Ace3provided by MGI
Official Full Name
angiotensin I converting enzyme 3provided by MGI
Primary source
MGI:MGI:3644400
See related
Ensembl:ENSMUSG00000101605 AllianceGenome:MGI:3644400
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EG217246
Summary
Predicted to enable metallopeptidase activity and peptidyl-dipeptidase activity. Predicted to be involved in positive regulation of systemic arterial blood pressure and regulation of systemic arterial blood pressure by renin-angiotensin. Located in acrosomal vesicle. Orthologous to human ACE3P (angiotensin I converting enzyme 3, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 16.2) See more
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Genomic context

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See Ace3 in Genome Data Viewer
Location:
11 E1; 11 68.86 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (105885424..105898376)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (105994588..106007550)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene cytochrome b-561 Neighboring gene predicted gene 9910 Neighboring gene STARR-seq mESC enhancer starr_30912 Neighboring gene predicted gene 11651 Neighboring gene angiotensin I converting enzyme Neighboring gene predicted gene, 35971 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 6 Neighboring gene STARR-positive B cell enhancer ABC_E43 Neighboring gene DDB1 and CUL4 associated factor 7 Neighboring gene translational activator of mitochondrially encoded cytochrome c oxidase I, opposite strand

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Angiotensin-Converting Enzyme 3 (ACE3) Protects Against Pressure Overload-Induced Cardiac Hypertrophy. Yu CJ, et al. J Am Heart Assoc, 2016 Feb 18. PMID 26892527, Free PMC Article
  2. Identification and disruption of sperm-specific angiotensin converting enzyme-3 (ACE3) in mouse. Inoue N, et al. PLoS One, 2010 Apr 22. PMID 20421979, Free PMC Article
  3. Identification and characterisation of the angiotensin converting enzyme-3 (ACE3) gene: a novel mammalian homologue of ACE. Rella M, et al. BMC Genomics, 2007 Jun 27. PMID 17597519, Free PMC Article
  4. Vascular wall ACE is not required for atherogenesis in ApoE(-/-) mice. Weiss D, et al. Atherosclerosis, 2010 Apr. PMID 19880118, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ACE3 inhibits pressure overload-induced cardiac hypertrophy by blocking the MEK-ERK1/2 signaling pathway.
    Title: Angiotensin-Converting Enzyme 3 (ACE3) Protects Against Pressure Overload-Induced Cardiac Hypertrophy.
  2. identified an IZUMO1-interacting protein in sperm, which was identified as testis specific ACE homologue ACE3.
    Title: Identification and disruption of sperm-specific angiotensin converting enzyme-3 (ACE3) in mouse.
  3. In the ACE 3/3 animals, atherosclerotic lesion area was not different from wild type controls despite reduced plasma ACE activity.
    Title: Vascular wall ACE is not required for atherogenesis in ApoE(-/-) mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-dipeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of systemic arterial blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of systemic arterial blood pressure by renin-angiotensin IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
angiotensin-converting enzyme-like protein Ace3
Names
angiotensin I converting enzyme (peptidyl-dipeptidase A) 3
NP_001094923.2
XP_006533116.1
XP_006533117.1
XP_006533119.1
XP_006533121.1
XP_006533122.1
XP_006533123.1
XP_030101747.1
XP_030101748.1
XP_030101749.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101453.3 → NP_001094923.2  angiotensin-converting enzyme-like protein Ace3 precursor

    See identical proteins and their annotated locations for NP_001094923.2

    Status: VALIDATED

    Source sequence(s)
    AL596331
    Consensus CDS
    CCDS59570.1
    UniProtKB/Swiss-Prot
    D0G895
    Related
    ENSMUSP00000140827.2, ENSMUST00000190995.2
    Conserved Domains (1) summary
    pfam01401
    Location:33 → 609
    Peptidase_M2; Angiotensin-converting enzyme

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    105885424..105898376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533054.5 → XP_006533117.1  angiotensin-converting enzyme-like protein Ace3 isoform X2

    Conserved Domains (1) summary
    pfam01401
    Location:51 → 635
    Peptidase_M2; Angiotensin-converting enzyme

  2. XM_030245887.2 → XP_030101747.1  angiotensin-converting enzyme-like protein Ace3 isoform X4

    Conserved Domains (1) summary
    pfam01401
    Location:51 → 587
    Peptidase_M2; Angiotensin-converting enzyme

  3. XM_006533056.5 → XP_006533119.1  angiotensin-converting enzyme-like protein Ace3 isoform X3

    Conserved Domains (1) summary
    pfam01401
    Location:51 → 618
    Peptidase_M2; Angiotensin-converting enzyme

  4. XM_006533053.5 → XP_006533116.1  angiotensin-converting enzyme-like protein Ace3 isoform X1

    Conserved Domains (1) summary
    pfam01401
    Location:51 → 647
    Peptidase_M2; Angiotensin-converting enzyme

  5. XM_006533058.5 → XP_006533121.1  angiotensin-converting enzyme-like protein Ace3 isoform X7

    Conserved Domains (1) summary
    pfam01401
    Location:51 → 595
    Peptidase_M2; Angiotensin-converting enzyme

  6. XM_006533059.5 → XP_006533122.1  angiotensin-converting enzyme-like protein Ace3 isoform X8

    Conserved Domains (1) summary
    pfam01401
    Location:51 → 594
    Peptidase_M2; Angiotensin-converting enzyme

  7. XM_006533060.5 → XP_006533123.1  angiotensin-converting enzyme-like protein Ace3 isoform X9

    Conserved Domains (1) summary
    cl14813
    Location:51 → 397
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  8. XM_030245888.2 → XP_030101748.1  angiotensin-converting enzyme-like protein Ace3 isoform X5

    Conserved Domains (1) summary
    pfam01401
    Location:26 → 561
    Peptidase_M2; Angiotensin-converting enzyme

  9. XM_030245889.2 → XP_030101749.1  angiotensin-converting enzyme-like protein Ace3 isoform X6

    Conserved Domains (1) summary
    pfam01401
    Location:26 → 549
    Peptidase_M2; Angiotensin-converting enzyme

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_012394.1: Suppressed sequence

    Description
    NG_012394.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D0G895.1 GenPept UniProtKB/Swiss-Prot:D0G895

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