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Dhx8 DEAH-box helicase 8 [ Mus musculus (house mouse) ]

Gene ID: 217207, updated on 11-Apr-2024

Summary

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Official Symbol
Dhx8provided by MGI
Official Full Name
DEAH-box helicase 8provided by MGI
Primary source
MGI:MGI:1306823
See related
Ensembl:ENSMUSG00000034931 AllianceGenome:MGI:1306823
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ddx8; mDEAH6; mKIAA4096
Summary
Predicted to enable RNA binding activity and identical protein binding activity. Predicted to be involved in spliceosomal complex disassembly. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in cytosol and nuclear body. Predicted to be part of U2-type catalytic step 2 spliceosome. Orthologous to human DHX8 (DEAH-box helicase 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.1), thymus adult (RPKM 9.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dhx8 in Genome Data Viewer
Location:
11 D; 11 65.48 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101623782..101658184)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101732956..101767358)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30778 Neighboring gene ADP-ribosylation factor-like 4D Neighboring gene predicted gene, 39391 Neighboring gene STARR-positive B cell enhancer ABC_E3025 Neighboring gene STARR-seq mESC enhancer starr_30780 Neighboring gene STARR-positive B cell enhancer ABC_E2371 Neighboring gene STARR-seq mESC enhancer starr_30781 Neighboring gene ets variant 4 Neighboring gene predicted gene, 39392 Neighboring gene STARR-positive B cell enhancer mm9_chr11:101674595-101674896 Neighboring gene mesenchyme homeobox 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning of mDEAH9, a putative RNA helicase and mammalian homologue of Saccharomyces cerevisiae splicing factor Prp43. Gee S, et al. Proc Natl Acad Sci U S A, 1997 Oct 28. PMID 9342318, Free PMC Article
  2. The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity. Hage A, et al. Cell Rep, 2022 Mar 8. PMID 35263596, Free PMC Article
  3. The protein interactome of collapsin response mediator protein-2 (CRMP2/DPYSL2) reveals novel partner proteins in brain tissue. Martins-de-Souza D, et al. Proteomics Clin Appl, 2015 Oct. PMID 25921334
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • KIAA4096, MGC31290

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in spliceosomal complex disassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of U2-type catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP-dependent RNA helicase DHX8
Names
DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 8
DEAH (Asp-Glu-Ala-His) box polypeptide 8
DEAH box protein 8
RNA helicase
NP_659080.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144831.2 → NP_659080.2  ATP-dependent RNA helicase DHX8

    See identical proteins and their annotated locations for NP_659080.2

    Status: VALIDATED

    Source sequence(s)
    BB654249, BC065064
    Consensus CDS
    CCDS25479.1
    UniProtKB/Swiss-Prot
    A2A4P0
    UniProtKB/TrEMBL
    Q3UQQ4
    Related
    ENSMUSP00000037251.8, ENSMUST00000039152.14
    Conserved Domains (6) summary
    smart00487
    Location:585 → 770
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:988 → 1070
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:606 → 744
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:769 → 926
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd05684
    Location:289 → 367
    S1_DHX8_helicase; S1_DHX8_helicase: The N-terminal S1 domain of human ATP-dependent RNA helicase DHX8, a DEAH (Asp-Glu-Ala-His) box polypeptide. The DEAH-box RNA helicases are thought to play key roles in pre-mRNA splicing and DHX8 facilitates nuclear export of spliced ...
    pfam07717
    Location:1104 → 1203
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    101623782..101658184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2A4P0.1 GenPept UniProtKB/Swiss-Prot:A2A4P0

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