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Tmem106a transmembrane protein 106A [ Mus musculus (house mouse) ]

Gene ID: 217203, updated on 5-Mar-2024

Summary

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Official Symbol
Tmem106aprovided by MGI
Official Full Name
transmembrane protein 106Aprovided by MGI
Primary source
MGI:MGI:1922056
See related
Ensembl:ENSMUSG00000034947 AllianceGenome:MGI:1922056
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610008L10Rik
Summary
Involved in several processes, including glycoprotein biosynthetic process; positive regulation of cytokine production; and positive regulation of intracellular signal transduction. Located in plasma membrane. Orthologous to human TMEM106A (transmembrane protein 106A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 64.7), placenta adult (RPKM 25.6) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem106a in Genome Data Viewer
Location:
11 D; 11 65.44 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101473068..101482612)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101582242..101591788)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene breast cancer 1, early onset Neighboring gene STARR-positive B cell enhancer mm9_chr11:101413133-101413434 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:101413898-101414007 Neighboring gene NBR1, autophagy cargo receptor Neighboring gene coiled coil domain containing 200 Neighboring gene STARR-seq mESC enhancer starr_30771 Neighboring gene predicted gene, 26316

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inactivation of TMEM106A promotes lipopolysaccharide-induced inflammation via the MAPK and NF-κB signaling pathways in macrophages. Zhang X, et al. Clin Exp Immunol, 2021 Jan. PMID 33006758, Free PMC Article
  2. Transmembrane protein 106a activates mouse peritoneal macrophages via the MAPK and NF-κB signaling pathways. Dai H, et al. Sci Rep, 2015 Jul 28. PMID 26215746, Free PMC Article
  3. DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice. Abdallah BM, et al. J Bone Miner Res, 2011 Jul. PMID 21308776
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inactivation of TMEM106A promotes lipopolysaccharide-induced inflammation via the MAPK and NF-kappaB signaling pathways in macrophages.
    Title: Inactivation of TMEM106A promotes lipopolysaccharide-induced inflammation via the MAPK and NF-κB signaling pathways in macrophages.
  2. data suggest that mouse Tmem106a might be a new trigger of macrophage activation and have some influence toward the M1 state through the activation of the MAPKs and NF-kappaB pathway
    Title: Transmembrane protein 106a activates mouse peritoneal macrophages via the MAPK and NF-κB signaling pathways.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC30290, MGC37887

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in CD80 biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in CD86 biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in macrophage activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of MHC class II biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of interleukin-1 beta production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of nitric oxide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transmembrane protein 106A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359325.1 → NP_001346254.1  transmembrane protein 106A

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 through 4 encode the same protein.
    Source sequence(s)
    AK149650, AK150285
    Consensus CDS
    CCDS25476.1
    UniProtKB/Swiss-Prot
    Q3U4J0, Q3U9D3, Q3UEA5, Q8CIC3, Q8VC04
    Conserved Domains (1) summary
    pfam07092
    Location:24 → 251
    DUF1356; Protein of unknown function (DUF1356)

  2. NM_001359326.1 → NP_001346255.1  transmembrane protein 106A

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 through 4 encode the same protein.
    Source sequence(s)
    AK149650, AK150285, AL590994, BY199928
    Consensus CDS
    CCDS25476.1
    UniProtKB/Swiss-Prot
    Q3U4J0, Q3U9D3, Q3UEA5, Q8CIC3, Q8VC04
    Related
    ENSMUSP00000097971.3, ENSMUST00000100403.9
    Conserved Domains (1) summary
    pfam07092
    Location:24 → 251
    DUF1356; Protein of unknown function (DUF1356)

  3. NM_001359327.1 → NP_001346256.1  transmembrane protein 106A

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1 through 4 encode the same protein.
    Source sequence(s)
    AK149650, AK150285, BY199928
    Consensus CDS
    CCDS25476.1
    UniProtKB/Swiss-Prot
    Q3U4J0, Q3U9D3, Q3UEA5, Q8CIC3, Q8VC04
    Conserved Domains (1) summary
    pfam07092
    Location:24 → 251
    DUF1356; Protein of unknown function (DUF1356)

  4. NM_144830.3 → NP_659079.1  transmembrane protein 106A

    See identical proteins and their annotated locations for NP_659079.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1 through 4 encode the same protein.
    Source sequence(s)
    AK146019
    Consensus CDS
    CCDS25476.1
    UniProtKB/Swiss-Prot
    Q3U4J0, Q3U9D3, Q3UEA5, Q8CIC3, Q8VC04
    Related
    ENSMUSP00000045832.8, ENSMUST00000039581.14
    Conserved Domains (1) summary
    pfam07092
    Location:24 → 251
    DUF1356; Protein of unknown function (DUF1356)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    101473068..101482612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VC04.1 GenPept UniProtKB/Swiss-Prot:Q8VC04

Gene LinkOut

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