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Plekhh3 pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 [ Mus musculus (house mouse) ]

Gene ID: 217198, updated on 5-Mar-2024

Summary

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Official Symbol
Plekhh3provided by MGI
Official Full Name
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3provided by MGI
Primary source
MGI:MGI:2384950
See related
Ensembl:ENSMUSG00000035172 AllianceGenome:MGI:2384950
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be involved in signal transduction. Predicted to be located in cytoskeleton. Orthologous to human PLEKHH3 (pleckstrin homology, MyTH4 and FERM domain containing H3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 28.6), ovary adult (RPKM 23.4) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 D; 11 64.32 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101053505..101062205, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101162679..101171378, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1843 Neighboring gene tubulin, gamma 1 Neighboring gene tubulin, gamma 2 Neighboring gene contactin associated protein-like 1 Neighboring gene C-C motif chemokine receptor 10 Neighboring gene enhancer of zeste 1 polycomb repressive complex 2 subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC27854

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pleckstrin homology domain-containing family H member 3
Names
PH domain-containing family H member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346769.1 → NP_001333698.1  pleckstrin homology domain-containing family H member 3 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AK164128, AL590969, BE332650
    Consensus CDS
    CCDS83899.1
    UniProtKB/Swiss-Prot
    Q8VCE9
    Related
    ENSMUSP00000127088.2, ENSMUST00000164474.8

  2. NM_146030.2 → NP_666142.1  pleckstrin homology domain-containing family H member 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_666142.1

    Status: VALIDATED

    Source sequence(s)
    AL590969
    Consensus CDS
    CCDS25453.1
    UniProtKB/Swiss-Prot
    Q3U3Z6, Q8R1H2, Q8VCE9
    Related
    ENSMUSP00000046044.8, ENSMUST00000043397.14
    Conserved Domains (5) summary
    pfam00169
    Location:96 → 199
    PH; PH domain
    pfam00784
    Location:288 → 397
    MyTH4; MyTH4 domain
    cl00155
    Location:409 → 459
    UBQ; Ubiquitin-like proteins
    cl09511
    Location:514 → 553
    FERM_B-lobe; FERM domain B-lobe
    cl17171
    Location:84 → 208
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    101053505..101062205 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245873.2 → XP_030101733.1  pleckstrin homology domain-containing family H member 3 isoform X2

    Conserved Domains (4) summary
    pfam00784
    Location:62 → 173
    MyTH4; MyTH4 domain
    cl09511
    Location:287 → 325
    FERM_B-lobe; FERM domain B-lobe
    cl17171
    Location:433 → 520
    PH-like; Pleckstrin homology-like domain
    cl28922
    Location:177 → 273
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  2. XM_030245871.2 → XP_030101731.1  pleckstrin homology domain-containing family H member 3 isoform X1

    Conserved Domains (4) summary
    pfam00784
    Location:62 → 173
    MyTH4; MyTH4 domain
    cl09511
    Location:290 → 328
    FERM_B-lobe; FERM domain B-lobe
    cl17171
    Location:436 → 523
    PH-like; Pleckstrin homology-like domain
    cl28922
    Location:177 → 276
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RNA

  1. XR_003949397.2 RNA Sequence

  2. XR_388417.5 RNA Sequence

    Related
    ENSMUST00000129895.8

  3. XR_003949401.2 RNA Sequence

  4. XR_003949399.2 RNA Sequence

  5. XR_003949400.2 RNA Sequence

  6. XR_003949398.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCE9.1 GenPept UniProtKB/Swiss-Prot:Q8VCE9

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