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Stac2 SH3 and cysteine rich domain 2 [ Mus musculus (house mouse) ]

Gene ID: 217154, updated on 7-Apr-2024

Summary

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Official Symbol
Stac2provided by MGI
Official Full Name
SH3 and cysteine rich domain 2provided by MGI
Primary source
MGI:MGI:2144518
See related
Ensembl:ENSMUSG00000017400 AllianceGenome:MGI:2144518
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
24b2; 24b2/STAC2
Summary
Predicted to enable metal ion binding activity. Involved in positive regulation of protein localization to plasma membrane and positive regulation of voltage-gated calcium channel activity. Is extrinsic component of cytoplasmic side of plasma membrane. Is expressed in metanephros. Orthologous to human STAC2 (SH3 and cysteine rich domain 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 12.8), cortex adult (RPKM 11.2) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 D; 11 61.58 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97927449..97944288, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98036623..98053462, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10711 Neighboring gene STARR-positive B cell enhancer ABC_E5274 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97861691-97862052 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97864016-97864125 Neighboring gene STARR-positive B cell enhancer ABC_E11491 Neighboring gene ADP-ribosylation factor-like 5C Neighboring gene calcium channel, voltage-dependent, beta 1 subunit Neighboring gene STARR-positive B cell enhancer ABC_E3013 Neighboring gene ribosomal protein L19 Neighboring gene STARR-positive B cell enhancer ABC_E9372 Neighboring gene STARR-seq mESC enhancer starr_30655 Neighboring gene STARR-seq mESC enhancer starr_30656 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97944979-97945162 Neighboring gene F-box and leucine-rich repeat protein 20 Neighboring gene mediator complex subunit 1 Neighboring gene ribosomal protein S6 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. STAC2 negatively regulates osteoclast formation by targeting the RANK signaling complex. Jeong E, et al. Cell Death Differ, 2018 Aug. PMID 29348675, Free PMC Article
  2. stac1 and stac2 genes define discrete and distinct subsets of dorsal root ganglia neurons. Legha W, et al. Gene Expr Patterns, 2010 Oct-Dec. PMID 20736085
  3. Stac proteins associate with the critical domain for excitation-contraction coupling in the II-III loop of Ca(V)1.1. Polster A, et al. J Gen Physiol, 2018 Apr 2. PMID 29467163, Free PMC Article
  4. Skeletal muscle-specific T-tubule protein STAC3 mediates voltage-induced Ca2+ release and contractility. Nelson BR, et al. Proc Natl Acad Sci U S A, 2013 Jul 16. PMID 23818578, Free PMC Article
  5. TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons. Caubit X, et al. Nat Genet, 2016 Nov. PMID 27668656, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC38869

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in positive regulation of protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of voltage-gated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in skeletal muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SH3 and cysteine-rich domain-containing protein 2
Names
SRC homology 3 and cysteine-rich domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146028.4 → NP_666140.1  SH3 and cysteine-rich domain-containing protein 2

    See identical proteins and their annotated locations for NP_666140.1

    Status: PROVISIONAL

    Source sequence(s)
    AL591209
    Consensus CDS
    CCDS25338.1
    UniProtKB/Swiss-Prot
    Q8BV93, Q8K2U4, Q8R1B0
    Related
    ENSMUSP00000017544.3, ENSMUST00000017544.9
    Conserved Domains (4) summary
    cd11985
    Location:293 → 345
    SH3_Stac2_C; C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing protein 2 (Stac2)
    cd00029
    Location:111 → 161
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam16664
    Location:167 → 292
    STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2
    cl17036
    Location:352 → 403
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    97927449..97944288 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245869.2 → XP_030101729.1  SH3 and cysteine-rich domain-containing protein 2 isoform X1

    Conserved Domains (3) summary
    cd11985
    Location:106 → 158
    SH3_Stac2_C; C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing protein 2 (Stac2)
    pfam16664
    Location:3 → 105
    STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2
    cl17036
    Location:165 → 216
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R1B0.1 GenPept UniProtKB/Swiss-Prot:Q8R1B0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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