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Cisd3 CDGSH iron sulfur domain 3 [ Mus musculus (house mouse) ]

Gene ID: 217149, updated on 5-Mar-2024

Summary

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Official Symbol
Cisd3provided by MGI
Official Full Name
CDGSH iron sulfur domain 3provided by MGI
Primary source
MGI:MGI:101788
See related
Ensembl:ENSMUSG00000078695 AllianceGenome:MGI:101788
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mel13; Mel-13
Summary
Predicted to enable 2 iron, 2 sulfur cluster binding activity and metal ion binding activity. Predicted to be involved in protein maturation by [2Fe-2S] cluster transfer. Located in mitochondrion. Orthologous to human CISD3 (CDGSH iron sulfur domain 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 67.3), duodenum adult (RPKM 51.1) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 D; 11 61.06 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97576291..97579451)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97685465..97688625)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11613 Neighboring gene STARR-positive B cell enhancer ABC_E3996 Neighboring gene STARR-seq mESC enhancer starr_30629 Neighboring gene myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6 Neighboring gene microRNA 6927 Neighboring gene STARR-positive B cell enhancer ABC_E7050 Neighboring gene polycomb group ring finger 2 Neighboring gene STARR-positive B cell enhancer ABC_E7051 Neighboring gene nuclear encoded tRNA asparagine 8 (anticodon GTT)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FGF4 improves hepatocytes ferroptosis in autoimmune hepatitis mice via activation of CISD3. Jiang H, et al. Int Immunopharmacol, 2023 Mar. PMID 36702076
  2. Cloning and characterization of two transcripts generated from the mel-13 gene positioned adjacent to the mammalian Polycomb group-related gene mel-18. Tetsu O, et al. Biochim Biophys Acta, 1996 Mar 1. PMID 8597592
  3. Nucleotide sequence of bup, an upstream gene in the bmi-1 proviral insertion locus. Haupt Y, et al. Mol Biol Rep, 1992 Nov. PMID 1287475
  4. Activation and negative selection of functionally distinct subsets of antibody-secreting cells by influenza hemagglutinin as a viral and a neo-self antigen. Caton AJ, et al. J Exp Med, 1996 Jan 1. PMID 8551216, Free PMC Article
  5. Mutagenic transgene insertion into a region of high gene density and multiple linkage disruptions on mouse chromosome 11. Kleiter N, et al. Cytogenet Genome Res, 2002. PMID 12438746

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FGF4 improves hepatocytes ferroptosis in autoimmune hepatitis mice via activation of CISD3.
    Title: FGF4 improves hepatocytes ferroptosis in autoimmune hepatitis mice via activation of CISD3.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2 iron, 2 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein maturation by [2Fe-2S] cluster transfer IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein maturation by [2Fe-2S] cluster transfer ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
CDGSH iron-sulfur domain-containing protein 3, mitochondrial
Names
melanoma nuclear protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085500.3 → NP_001078969.2  CDGSH iron-sulfur domain-containing protein 3, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_001078969.2

    Status: VALIDATED

    Source sequence(s)
    AA987107, AI414532, BC056217
    Consensus CDS
    CCDS48896.1
    UniProtKB/Swiss-Prot
    B1AR11, B1AR12, B1AR13
    UniProtKB/TrEMBL
    Z4YKM2
    Related
    ENSMUSP00000103209.3, ENSMUST00000107583.3
    Conserved Domains (2) summary
    pfam09360
    Location:56 → 85
    zf-CDGSH; Iron-binding zinc finger CDGSH type
    cl02748
    Location:93 → 129
    zf-CDGSH; Iron-binding zinc finger CDGSH type

  2. NM_001364153.1 → NP_001351082.1  CDGSH iron-sulfur domain-containing protein 3, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL596123, BC147739
    UniProtKB/TrEMBL
    B3DFI8
    Conserved Domains (1) summary
    pfam09360
    Location:136 → 165
    zf-CDGSH; Iron-binding zinc finger CDGSH type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    97576291..97579451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533029.3 → XP_006533092.1  CDGSH iron-sulfur domain-containing protein 3, mitochondrial isoform X1

    UniProtKB/TrEMBL
    B3DFI8
    Conserved Domains (1) summary
    pfam09360
    Location:117 → 146
    zf-CDGSH; Iron-binding zinc finger CDGSH type
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1AR13.1 GenPept UniProtKB/Swiss-Prot:B1AR13

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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