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Kat7 K(lysine) acetyltransferase 7 [ Mus musculus (house mouse) ]

Gene ID: 217127, updated on 11-Apr-2024

Summary

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Official Symbol
Kat7provided by MGI
Official Full Name
K(lysine) acetyltransferase 7provided by MGI
Primary source
MGI:MGI:2182799
See related
Ensembl:ENSMUSG00000038909 AllianceGenome:MGI:2182799
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hbo1; Hboa; Myst2
Summary
Enables histone acetyltransferase activity. Involved in several processes, including histone H3-K14 acetylation; positive regulation of erythrocyte differentiation; and positive regulation of transcription, DNA-templated. Located in nucleus. Part of histone H3-K14 acetyltransferase complex. Is expressed in brain; early conceptus; genitourinary system; and limb. Orthologous to human KAT7 (lysine acetyltransferase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 20.1), placenta adult (RPKM 13.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 D; 11 59.01 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (95162683..95201030, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (95271853..95310246, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11515 Neighboring gene tachykinin 4 Neighboring gene STARR-positive B cell enhancer ABC_E9370 Neighboring gene STARR-positive B cell enhancer ABC_E9840 Neighboring gene STARR-positive B cell enhancer ABC_E376 Neighboring gene STARR-positive B cell enhancer ABC_E1841 Neighboring gene predicted gene 11520 Neighboring gene STARR-seq mESC enhancer starr_30502 Neighboring gene STARR-positive B cell enhancer ABC_E594 Neighboring gene family with sequence similarity 117, member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The histone lysine acetyltransferase HBO1 (KAT7) regulates hematopoietic stem cell quiescence and self-renewal. Yang Y, et al. Blood, 2022 Feb 10. PMID 34724565
  2. The histone acetyltransferase HBO1 promotes efficient tip cell sprouting during angiogenesis. Grant ZL, et al. Development, 2021 Oct 15. PMID 34550360
  3. Circ-myh8 Promotes Pulmonary Hypertension by Recruiting KAT7 to Govern Hypoxia-Inducible Factor-1α Expression. Xing Y, et al. J Am Heart Assoc, 2023 Apr 4. PMID 36942752, Free PMC Article
  4. The acetyltransferase KAT7 is required for thymic epithelial cell expansion, expression of AIRE target genes, and thymic tolerance. Heinlein M, et al. Sci Immunol, 2022 Jan 21. PMID 35061506
  5. MEAF6 is essential for cell proliferation and plays a role in the assembly of KAT7 complexes. Matsuura K, et al. Exp Cell Res, 2020 Nov 1. PMID 32918898

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circ-myh8 Promotes Pulmonary Hypertension by Recruiting KAT7 to Govern Hypoxia-Inducible Factor-1alpha Expression.
    Title: Circ-myh8 Promotes Pulmonary Hypertension by Recruiting KAT7 to Govern Hypoxia-Inducible Factor-1α Expression.
  2. The acetyltransferase KAT7 is required for thymic epithelial cell expansion, expression of AIRE target genes, and thymic tolerance.
    Title: The acetyltransferase KAT7 is required for thymic epithelial cell expansion, expression of AIRE target genes, and thymic tolerance.
  3. The histone lysine acetyltransferase HBO1 (KAT7) regulates hematopoietic stem cell quiescence and self-renewal.
    Title: The histone lysine acetyltransferase HBO1 (KAT7) regulates hematopoietic stem cell quiescence and self-renewal.
  4. The histone acetyltransferase HBO1 promotes efficient tip cell sprouting during angiogenesis.
    Title: The histone acetyltransferase HBO1 promotes efficient tip cell sprouting during angiogenesis.
  5. BRPF3-HUWE1-mediated regulation of MYST2 is required for differentiation and cell-cycle progression in embryonic stem cells.
    Title: BRPF3-HUWE1-mediated regulation of MYST2 is required for differentiation and cell-cycle progression in embryonic stem cells.
  6. MEAF6 is essential for cell proliferation and plays a role in the assembly of KAT7 complexes.
    Title: MEAF6 is essential for cell proliferation and plays a role in the assembly of KAT7 complexes.
  7. The Protective Effect of HBO1 on Cigarette Smoke Extract-Induced Apoptosis in Airway Epithelial Cells.
    Title: The Protective Effect of HBO1 on Cigarette Smoke Extract-Induced Apoptosis in Airway Epithelial Cells.
  8. The data provides a useful resource for exploring Myst2 and Niam essential cellular functions and should contribute to deeper understanding of organism early development and survival as well as cancer.
    Title: Myst2/Kat7 histone acetyltransferase interaction proteomics reveals tumour-suppressor Niam as a novel binding partner in embryonic stem cells.
  9. a nonredundant role for KAT7 in the maintenance of Histone h 3 lusine 14 acetylation, which is intimately linked with the ability to develop a normal immune system, is reported.
    Title: Essential role for the histone acetyltransferase KAT7 in T cell development, fitness, and survival.
  10. These results indicate that BRPF3 forms a functional tetrameric complex with HBO1 but is not required for mouse development and survival
    Title: The Chromatin Regulator BRPF3 Preferentially Activates the HBO1 Acetyltransferase but Is Dispensable for Mouse Development and Survival.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC56758

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA replication origin binding ISO
Inferred from Sequence Orthology
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K14 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K14 acetyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone H3K14 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3K23 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3K4 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H4 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4K12 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4K5 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4K8 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication-dependent chromatin disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in internal peptidyl-lysine acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in natural killer cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription, elongation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of hematopoietic stem cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of hematopoietic stem cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated DNA replication initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to actinomycin D ISO
Inferred from Sequence Orthology
more info
  
involved_in response to anisomycin ISO
Inferred from Sequence Orthology
more info
  
involved_in response to dithiothreitol ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hydroxyurea ISO
Inferred from Sequence Orthology
more info
  
involved_in response to sorbitol ISO
Inferred from Sequence Orthology
more info
  
involved_in stress-activated protein kinase signaling cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation-coupled chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription initiation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of histone H3-K14 acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of histone H3-K14 acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of histone H3-K14 acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
histone acetyltransferase KAT7
Names
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2
MYST histone acetyltransferase 2
histone acetyltransferase MYST2
histone acetyltransferase binding to ORC1
lysine acetyltransferase 7
NP_001181932.1
NP_001181933.1
NP_001392123.1
NP_001392124.1
NP_001392125.1
NP_001392126.1
NP_001392127.1
NP_001392128.1
NP_001392129.1
NP_001392130.1
NP_001392131.1
NP_001392132.1
NP_001392133.1
NP_001392134.1
NP_001392135.1
NP_001392136.1
NP_001392137.1
NP_001392138.1
NP_001392139.1
NP_001392140.1
NP_001392141.1
NP_001392142.1
NP_001392143.1
NP_001392144.1
NP_001392145.1
NP_001392146.1
NP_001392147.1
NP_001392148.1
NP_001392149.1
NP_001392150.1
NP_001392151.1
NP_001392152.1
NP_001392153.1
NP_001392154.1
NP_001392155.1
NP_001392156.1
NP_808287.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195003.2 → NP_001181932.1  histone acetyltransferase KAT7 isoform 1

    See identical proteins and their annotated locations for NP_001181932.1

    Status: VALIDATED

    Source sequence(s)
    AL627222
    Consensus CDS
    CCDS56799.1
    UniProtKB/TrEMBL
    A0AA74KSS6, Q1AJD0
    Related
    ENSMUSP00000103362.4, ENSMUST00000107734.10
    Conserved Domains (3) summary
    PLN00104
    Location:324 → 609
    PLN00104; MYST -like histone acetyltransferase; Provisional
    pfam05109
    Location:27 → 197
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01530
    Location:184 → 212
    zf-C2HC; Zinc finger, C2HC type

  2. NM_001195004.2 → NP_001181933.1  histone acetyltransferase KAT7 isoform 2

    See identical proteins and their annotated locations for NP_001181933.1

    Status: VALIDATED

    Source sequence(s)
    AL627222
    Consensus CDS
    CCDS56798.1
    UniProtKB/TrEMBL
    A0AA74KSS6, Q3TD41
    Related
    ENSMUSP00000103361.4, ENSMUST00000107733.10
    Conserved Domains (4) summary
    PLN00104
    Location:294 → 579
    PLN00104; MYST -like histone acetyltransferase; Provisional
    pfam05109
    Location:27 → 197
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd16378
    Location:209 → 262
    CcmH_N; N-terminal domain of cytochrome c-type biogenesis protein CcmH and related proteins
    pfam01530
    Location:184 → 212
    zf-C2HC; Zinc finger, C2HC type

  3. NM_001405194.1 → NP_001392123.1  histone acetyltransferase KAT7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL627222
    UniProtKB/Swiss-Prot
    Q5SVQ0, Q5SVQ1, Q5SVQ2, Q5SVQ3, Q5SVQ7, Q6PGC6, Q80Y65
    Related
    ENSMUSP00000090441.6, ENSMUST00000092766.12

  4. NM_001405195.1 → NP_001392124.1  histone acetyltransferase KAT7 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL627222

  5. NM_001405196.1 → NP_001392125.1  histone acetyltransferase KAT7 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL627222

  6. NM_001405197.1 → NP_001392126.1  histone acetyltransferase KAT7 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL627222
    Related
    ENSMUSP00000072416.6, ENSMUST00000072621.12

  7. NM_001405198.1 → NP_001392127.1  histone acetyltransferase KAT7 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL627222

  8. NM_001405199.1 → NP_001392128.1  histone acetyltransferase KAT7 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL627222

  9. NM_001405200.1 → NP_001392129.1  histone acetyltransferase KAT7 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL627222

  10. NM_001405201.1 → NP_001392130.1  histone acetyltransferase KAT7 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL627222

  11. NM_001405202.1 → NP_001392131.1  histone acetyltransferase KAT7 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL627222

  12. NM_001405203.1 → NP_001392132.1  histone acetyltransferase KAT7 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL627222

  13. NM_001405204.1 → NP_001392133.1  histone acetyltransferase KAT7 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AL627222

  14. NM_001405205.1 → NP_001392134.1  histone acetyltransferase KAT7 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AL627222

  15. NM_001405206.1 → NP_001392135.1  histone acetyltransferase KAT7 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AL627222

  16. NM_001405207.1 → NP_001392136.1  histone acetyltransferase KAT7 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AL627222

  17. NM_001405208.1 → NP_001392137.1  histone acetyltransferase KAT7 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AL627222

  18. NM_001405209.1 → NP_001392138.1  histone acetyltransferase KAT7 isoform 19

    Status: VALIDATED

    Source sequence(s)
    AL627222

  19. NM_001405210.1 → NP_001392139.1  histone acetyltransferase KAT7 isoform 20

    Status: VALIDATED

    Source sequence(s)
    AL627222

  20. NM_001405211.1 → NP_001392140.1  histone acetyltransferase KAT7 isoform 21

    Status: VALIDATED

    Source sequence(s)
    AL627222
    UniProtKB/TrEMBL
    Q3UGU8

  21. NM_001405212.1 → NP_001392141.1  histone acetyltransferase KAT7 isoform 22

    Status: VALIDATED

    Source sequence(s)
    AL627222

  22. NM_001405213.1 → NP_001392142.1  histone acetyltransferase KAT7 isoform 23

    Status: VALIDATED

    Source sequence(s)
    AL627222

  23. NM_001405214.1 → NP_001392143.1  histone acetyltransferase KAT7 isoform 24

    Status: VALIDATED

    Source sequence(s)
    AL627222

  24. NM_001405215.1 → NP_001392144.1  histone acetyltransferase KAT7 isoform 25

    Status: VALIDATED

    Source sequence(s)
    AL627222

  25. NM_001405216.1 → NP_001392145.1  histone acetyltransferase KAT7 isoform 21

    Status: VALIDATED

    Source sequence(s)
    AL627222
    UniProtKB/TrEMBL
    Q3UGU8

  26. NM_001405217.1 → NP_001392146.1  histone acetyltransferase KAT7 isoform 21

    Status: VALIDATED

    Source sequence(s)
    AL627222
    UniProtKB/TrEMBL
    Q3UGU8

  27. NM_001405218.1 → NP_001392147.1  histone acetyltransferase KAT7 isoform 21

    Status: VALIDATED

    Source sequence(s)
    AL627222
    UniProtKB/TrEMBL
    Q3UGU8

  28. NM_001405219.1 → NP_001392148.1  histone acetyltransferase KAT7 isoform 21

    Status: VALIDATED

    Source sequence(s)
    AL627222
    UniProtKB/TrEMBL
    Q3UGU8

  29. NM_001405220.1 → NP_001392149.1  histone acetyltransferase KAT7 isoform 22

    Status: VALIDATED

    Source sequence(s)
    AL627222

  30. NM_001405221.1 → NP_001392150.1  histone acetyltransferase KAT7 isoform 22

    Status: VALIDATED

    Source sequence(s)
    AL627222

  31. NM_001405222.1 → NP_001392151.1  histone acetyltransferase KAT7 isoform 22

    Status: VALIDATED

    Source sequence(s)
    AL627222

  32. NM_001405223.1 → NP_001392152.1  histone acetyltransferase KAT7 isoform 22

    Status: VALIDATED

    Source sequence(s)
    AL627222

  33. NM_001405224.1 → NP_001392153.1  histone acetyltransferase KAT7 isoform 22

    Status: VALIDATED

    Source sequence(s)
    AL627222

  34. NM_001405225.1 → NP_001392154.1  histone acetyltransferase KAT7 isoform 23

    Status: VALIDATED

    Source sequence(s)
    AL627222

  35. NM_001405226.1 → NP_001392155.1  histone acetyltransferase KAT7 isoform 25

    Status: VALIDATED

    Source sequence(s)
    AL627222

  36. NM_001405227.1 → NP_001392156.1  histone acetyltransferase KAT7 isoform 26

    Status: VALIDATED

    Source sequence(s)
    AL627222

  37. NM_177619.4 → NP_808287.1  histone acetyltransferase KAT7 isoform 3

    See identical proteins and their annotated locations for NP_808287.1

    Status: VALIDATED

    Source sequence(s)
    AL627222
    Consensus CDS
    CCDS25275.1
    UniProtKB/TrEMBL
    A0AA74KSS6
    Related
    ENSMUSP00000099448.4, ENSMUST00000103159.10
    Conserved Domains (2) summary
    pfam01530
    Location:125 → 153
    zf-C2HC; Zinc finger, C2HC type
    cl27485
    Location:235 → 520
    MOZ_SAS; MOZ/SAS family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    95162683..95201030 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SVQ0.1 GenPept UniProtKB/Swiss-Prot:Q5SVQ0

Gene LinkOut

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