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Samd14 sterile alpha motif domain containing 14 [ Mus musculus (house mouse) ]

Gene ID: 217125, updated on 16-Apr-2024

Summary

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Official Symbol
Samd14provided by MGI
Official Full Name
sterile alpha motif domain containing 14provided by MGI
Primary source
MGI:MGI:2384945
See related
Ensembl:ENSMUSG00000047181 AllianceGenome:MGI:2384945
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization; calcium-mediated signaling; and neuron projection development. Predicted to be active in several cellular components, including actin cytoskeleton; dendrite; and postsynaptic density. Is expressed in liver lobe; nervous system; neural retina; and olfactory epithelium. Orthologous to human SAMD14 (sterile alpha motif domain containing 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 45.4), CNS E14 (RPKM 40.9) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Samd14 in Genome Data Viewer
Location:
11 D; 11 59.01 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (94900213..94916913)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (95009395..95026087)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene sarcoglycan, alpha (dystrophin-associated glycoprotein) Neighboring gene H1.9 linker histone Neighboring gene STARR-positive B cell enhancer ABC_E7047 Neighboring gene STARR-seq mESC enhancer starr_30478 Neighboring gene STARR-seq mESC enhancer starr_30479 Neighboring gene STARR-positive B cell enhancer ABC_E3995 Neighboring gene protein phosphatase 1, regulatory subunit 9B Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:94859496-94859731 Neighboring gene predicted gene, 51875 Neighboring gene pyruvate dehydrogenase kinase, isoenzyme 2 Neighboring gene predicted gene, 53200 Neighboring gene predicted gene 11513

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional requirements for a Samd14-capping protein complex in stress erythropoiesis. Ray S, et al. Elife, 2022 Jun 17. PMID 35713400, Free PMC Article
  2. Sterile α-motif domain requirement for cellular signaling and survival. Ray S, et al. J Biol Chem, 2020 May 15. PMID 32241909, Free PMC Article
  3. GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia. Hewitt KJ, et al. Dev Cell, 2017 Aug 7. PMID 28787589, Free PMC Article
  4. Proteomic analysis of in vivo phosphorylated synaptic proteins. Collins MO, et al. J Biol Chem, 2005 Feb 18. PMID 15572359
  5. Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. Quina LA, et al. J Neurosci, 2009 Nov 11. PMID 19906978, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Physiological and regenerative functions of sterile-alpha motif protein-14 in hematopoiesis.
    Title: Physiological and regenerative functions of sterile-α motif protein-14 in hematopoiesis.
  2. Functional requirements for a Samd14-capping protein complex in stress erythropoiesis.
    Title: Functional requirements for a Samd14-capping protein complex in stress erythropoiesis.
  3. The Samd14 enhancer is essential for erythrocyte regeneration in severe anemia.
    Title: GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC31049

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sterile alpha motif domain-containing protein 14
Names
SAM domain-containing protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364135.1 → NP_001351064.1  sterile alpha motif domain-containing protein 14 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606480
    Conserved Domains (2) summary
    cd09512
    Location:323 → 388
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    cl28033
    Location:45 → 236
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  2. NM_001364136.1 → NP_001351065.1  sterile alpha motif domain-containing protein 14 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL606480
    Conserved Domains (1) summary
    cd09512
    Location:255 → 320
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily

  3. NM_146025.2 → NP_666137.1  sterile alpha motif domain-containing protein 14 isoform 2

    See identical proteins and their annotated locations for NP_666137.1

    Status: VALIDATED

    Source sequence(s)
    AI854782, AK049753, BC034054
    Consensus CDS
    CCDS25269.1
    UniProtKB/Swiss-Prot
    Q5SWB7, Q8BHE2, Q8C8N5, Q8K070
    Related
    ENSMUSP00000062231.4, ENSMUST00000055947.10
    Conserved Domains (2) summary
    cd09512
    Location:321 → 386
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    smart00454
    Location:323 → 386
    SAM; Sterile alpha motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    94900213..94916913
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248936.4 → XP_011247238.1  sterile alpha motif domain-containing protein 14 isoform X2

    Conserved Domains (2) summary
    PHA03307
    Location:45 → 236
    PHA03307; transcriptional regulator ICP4; Provisional
    cl15755
    Location:317 → 336
    SAM_superfamily; SAM (Sterile alpha motif )

  2. XM_030245857.2 → XP_030101717.1  sterile alpha motif domain-containing protein 14 isoform X3

    Conserved Domains (2) summary
    PHA03307
    Location:39 → 234
    PHA03307; transcriptional regulator ICP4; Provisional
    cl15755
    Location:315 → 334
    SAM_superfamily; SAM (Sterile alpha motif )

  3. XM_006533011.4 → XP_006533074.1  sterile alpha motif domain-containing protein 14 isoform X1

    Conserved Domains (1) summary
    cd09512
    Location:309 → 374
    SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K070.1 GenPept UniProtKB/Swiss-Prot:Q8K070

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