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Ggnbp2 gametogenetin binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 217039, updated on 5-Mar-2024

Summary

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Official Symbol
Ggnbp2provided by MGI
Official Full Name
gametogenetin binding protein 2provided by MGI
Primary source
MGI:MGI:2387356
See related
Ensembl:ENSMUSG00000020530 AllianceGenome:MGI:2387356
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DIF-3; Zfp403; D330017P12Rik
Summary
Acts upstream of or within several processes, including labyrinthine layer blood vessel development; negative regulation of cell population proliferation; and negative regulation of protein phosphorylation. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; retina; and spleen. Orthologous to human GGNBP2 (gametogenetin binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 45.3), liver E14 (RPKM 28.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Ggnbp2 in Genome Data Viewer
Location:
11 C; 11 51.34 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (84723187..84761668, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (84832361..84870837, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930502E09 gene Neighboring gene dehydrogenase/reductase 11 Neighboring gene STARR-positive B cell enhancer ABC_E3986 Neighboring gene STARR-seq mESC enhancer starr_30226 Neighboring gene STARR-seq mESC enhancer starr_30227 Neighboring gene STARR-positive B cell enhancer ABC_E7033 Neighboring gene gametogenetin binding protein 2, opposite strand Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class W Neighboring gene myosin XIX Neighboring gene zinc finger, HIT type 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ggnbp2-Null Mutation in Mice Leads to Male Infertility due to a Defect at the Spermiogenesis Stage. Liu L, et al. Am J Pathol, 2017 Nov. PMID 28823874, Free PMC Article
  2. GGNBP2 is necessary for testis morphology and sperm development. Chen A, et al. Sci Rep, 2017 Jun 7. PMID 28592902, Free PMC Article
  3. Ablation of Ggnbp2 impairs meiotic DNA double-strand break repair during spermatogenesis in mice. Guo K, et al. J Cell Mol Med, 2018 Oct. PMID 30055035, Free PMC Article
  4. Dioxin induces a novel nuclear factor, DIF-3, that is implicated in spermatogenesis. Ohbayashi T, et al. FEBS Lett, 2001 Nov 23. PMID 11728448
  5. Fbxo45 promotes the malignant development of esophageal squamous cell carcinoma by targeting GGNBP2 for ubiquitination and degradation. Wang Q, et al. Oncogene, 2022 Oct. PMID 36127399

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fbxo45 promotes the malignant development of esophageal squamous cell carcinoma by targeting GGNBP2 for ubiquitination and degradation.
    Title: Fbxo45 promotes the malignant development of esophageal squamous cell carcinoma by targeting GGNBP2 for ubiquitination and degradation.
  2. these data suggest that GGNBP2, likely mediated by its interaction with GGN1, plays a role in DNA double-strand break repair during meiotic progression of spermatocytes.
    Title: Ablation of Ggnbp2 impairs meiotic DNA double-strand break repair during spermatogenesis in mice.
  3. These results suggest that GGNBP2 plays a key role in spermatogenesis by affecting the morphology and function of SOX9-positive Sertoli cells.
    Title: GGNBP2 is necessary for testis morphology and sperm development.
  4. demonstrates that GGNBP2 is critically required for maintenance of the adhesion integrity of the adlumenal germ epithelium and is indispensable for normal spermatid transformation into mature spermatozoa in mice
    Title: Ggnbp2-Null Mutation in Mice Leads to Male Infertility due to a Defect at the Spermiogenesis Stage.
  5. GGNBP2 is an essential factor for pregnancy success acting through the maintenance of a balance of trophoblast stem cell proliferation and differentiation during placental development.
    Title: Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation.
  6. Ggnbp2 is mainly expressed in the testis. Its protein product interacted with GGN1 and could be involved in intracellular trafficking.
    Title: Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are potential interaction partners of testicular germ cell-specific protein GGN1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within labyrinthine layer blood vessel development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within labyrinthine layer development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation of STAT protein IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of tyrosine phosphorylation of STAT protein IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
gametogenetin-binding protein 2
Names
dioxin inducible factor 3
gametogenin binding protein 2
zinc finger protein 403

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364111.1 → NP_001351040.1  gametogenetin-binding protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL596083, AL645623
    UniProtKB/TrEMBL
    H7BX83

  2. NM_001364112.1 → NP_001351041.1  gametogenetin-binding protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL596083, AL645623
    Consensus CDS
    CCDS88211.1
    UniProtKB/TrEMBL
    H7BX83
    Related
    ENSMUSP00000018547.3, ENSMUST00000018547.9

  3. NM_001364114.1 → NP_001351043.1  gametogenetin-binding protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL596083, AL645623
    Consensus CDS
    CCDS88210.1
    UniProtKB/Swiss-Prot
    A4QPD5, B7ZP33, Q5SV75, Q5SV76, Q5SV77, Q5SV78, Q6GVH6, Q6P9J4, Q920N4
    UniProtKB/TrEMBL
    H7BX83
    Related
    ENSMUSP00000130013.2, ENSMUST00000168434.8

  4. NM_001364115.1 → NP_001351044.1  gametogenetin-binding protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL596083, AL645623
    Consensus CDS
    CCDS88210.1
    UniProtKB/Swiss-Prot
    A4QPD5, B7ZP33, Q5SV75, Q5SV76, Q5SV77, Q5SV78, Q6GVH6, Q6P9J4, Q920N4
    UniProtKB/TrEMBL
    H7BX83
    Related
    ENSMUSP00000098252.4, ENSMUST00000100686.10

  5. NM_153144.3 → NP_694784.2  gametogenetin-binding protein 2 isoform 3

    See identical proteins and their annotated locations for NP_694784.2

    Status: VALIDATED

    Source sequence(s)
    AB064543, AL645623, AY633741, BE982217
    Consensus CDS
    CCDS36262.1
    UniProtKB/TrEMBL
    H7BX83
    Related
    ENSMUSP00000127584.2, ENSMUST00000172405.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    84723187..84761668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245848.2 → XP_030101708.1  gametogenetin-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    H7BX83

  2. XM_017314473.3 → XP_017169962.1  gametogenetin-binding protein 2 isoform X7

    UniProtKB/TrEMBL
    H7BX83
    Related
    ENSMUSP00000103716.3, ENSMUST00000108081.9

  3. XM_030245849.1 → XP_030101709.1  gametogenetin-binding protein 2 isoform X6

    UniProtKB/TrEMBL
    H7BX83

  4. XM_030245854.1 → XP_030101714.1  gametogenetin-binding protein 2 isoform X8

    UniProtKB/Swiss-Prot
    A4QPD5, B7ZP33, Q5SV75, Q5SV76, Q5SV77, Q5SV78, Q6GVH6, Q6P9J4, Q920N4
    UniProtKB/TrEMBL
    H7BX83
    Related
    ENSMUSP00000117482.3, ENSMUST00000154915.9

  5. XM_030245853.1 → XP_030101713.1  gametogenetin-binding protein 2 isoform X7

    UniProtKB/TrEMBL
    H7BX83

  6. XM_030245850.2 → XP_030101710.1  gametogenetin-binding protein 2 isoform X7

    UniProtKB/TrEMBL
    H7BX83

  7. XM_036156586.1 → XP_036012479.1  gametogenetin-binding protein 2 isoform X6

    UniProtKB/TrEMBL
    H7BX83

  8. XM_030245851.2 → XP_030101711.1  gametogenetin-binding protein 2 isoform X8

    UniProtKB/Swiss-Prot
    A4QPD5, B7ZP33, Q5SV75, Q5SV76, Q5SV77, Q5SV78, Q6GVH6, Q6P9J4, Q920N4
    UniProtKB/TrEMBL
    H7BX83

  9. XM_036156585.1 → XP_036012478.1  gametogenetin-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    H7BX83

  10. XM_030245847.2 → XP_030101707.1  gametogenetin-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    H7BX83

  11. XM_030245846.2 → XP_030101706.1  gametogenetin-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    H7BX83

  12. XM_017314471.3 → XP_017169960.1  gametogenetin-binding protein 2 isoform X4

    UniProtKB/TrEMBL
    H7BX83

  13. XM_017314472.2 → XP_017169961.1  gametogenetin-binding protein 2 isoform X5

    UniProtKB/TrEMBL
    H7BX83
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SV77.1 GenPept UniProtKB/Swiss-Prot:Q5SV77

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