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Synrg synergin, gamma [ Mus musculus (house mouse) ]

Gene ID: 217030, updated on 30-Apr-2024

Summary

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Official Symbol
Synrgprovided by MGI
Official Full Name
synergin, gammaprovided by MGI
Primary source
MGI:MGI:1354742
See related
Ensembl:ENSMUSG00000034940 AllianceGenome:MGI:1354742
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SYNG; Ap1gbp1
Summary
Predicted to act upstream of or within endocytosis and protein transport. Predicted to be located in Golgi apparatus; cytoplasmic vesicle; and membrane. Predicted to be part of clathrin coat of trans-Golgi network vesicle. Is expressed in several structures, including cardiovascular system; gallbladder; genitourinary system; gut; and nervous system. Orthologous to human SYNRG (synergin gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 8.6), thymus adult (RPKM 8.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 C; 11 51.25 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (83855217..83935404)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (83964390..84044578)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30206 Neighboring gene STARR-seq mESC enhancer starr_30207 Neighboring gene HNF1 homeobox B Neighboring gene predicted gene, 51869 Neighboring gene STARR-positive B cell enhancer ABC_E5256 Neighboring gene STARR-positive B cell enhancer ABC_E11769 Neighboring gene DExD box helicase 52 Neighboring gene STARR-positive B cell enhancer mm9_chr11:83845520-83845821 Neighboring gene STARR-seq mESC enhancer starr_30212 Neighboring gene dual specificity phosphatase 14 Neighboring gene transcriptional adaptor 2A Neighboring gene acetyl-Coenzyme A carboxylase alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and cloning of differentially expressed genes by long-distance differential display. Jurecic R, et al. Anal Biochem, 1998 Jun 1. PMID 9618202
  2. Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin. Lui WW, et al. Mol Biol Cell, 2003 Jun. PMID 12808037, Free PMC Article
  3. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • L71-5

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin coat of trans-Golgi network vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of clathrin coat of trans-Golgi network vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
synergin gamma
Names
AP1 gamma subunit binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001405109.1 → NP_001392038.1  synergin gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL645615
    UniProtKB/TrEMBL
    V9GX40
    Related
    ENSMUSP00000138969.2, ENSMUST00000183456.8

  2. NM_001405112.1 → NP_001392041.1  synergin gamma isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645615

  3. NM_001405113.1 → NP_001392042.1  synergin gamma isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL645615
    Related
    ENSMUSP00000059000.9, ENSMUST00000049714.15

  4. NM_001405115.1 → NP_001392044.1  synergin gamma isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL645615

  5. NM_001405116.1 → NP_001392045.1  synergin gamma isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL645615

  6. NM_001405118.1 → NP_001392047.1  synergin gamma isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL645615
    UniProtKB/TrEMBL
    V9GXD9
    Related
    ENSMUSP00000139103.2, ENSMUST00000183714.8

  7. NM_001405121.1 → NP_001392050.1  synergin gamma isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL645615

  8. NM_001405122.1 → NP_001392051.1  synergin gamma isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL645615

  9. NM_001405123.1 → NP_001392052.1  synergin gamma isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL645615

  10. NM_194341.3 → NP_919322.1  synergin gamma isoform 7

    See identical proteins and their annotated locations for NP_919322.1

    Status: VALIDATED

    Source sequence(s)
    AL645615
    Consensus CDS
    CCDS25181.1
    UniProtKB/Swiss-Prot
    Q5SV84, Q5SV85, Q6PHT6
    Related
    ENSMUSP00000090510.6, ENSMUST00000092834.12
    Conserved Domains (2) summary
    cd00052
    Location:235 → 286
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cl00928
    Location:113 → 147
    dsDNA_bind; Double-stranded DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    83855217..83935404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532979.5 → XP_006533042.1  synergin gamma isoform X1

    UniProtKB/Swiss-Prot
    Q5SV84, Q5SV85, Q6PHT6
    Conserved Domains (4) summary
    cd00052
    Location:415 → 466
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam09606
    Location:30 → 242
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam15346
    Location:114 → 147
    ARGLU; Arginine and glutamate-rich 1
    pfam16014
    Location:469 → 537
    SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

  2. XM_006532985.5 → XP_006533048.1  synergin gamma isoform X8

    UniProtKB/Swiss-Prot
    Q5SV84, Q5SV85, Q6PHT6
    Conserved Domains (4) summary
    cd00052
    Location:236 → 287
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam09606
    Location:30 → 129
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam15346
    Location:114 → 147
    ARGLU; Arginine and glutamate-rich 1
    pfam16014
    Location:290 → 358
    SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

  3. XM_006532988.5 → XP_006533051.1  synergin gamma isoform X10

    UniProtKB/Swiss-Prot
    Q5SV84, Q5SV85, Q6PHT6
    Conserved Domains (4) summary
    cd00052
    Location:236 → 287
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam09606
    Location:30 → 129
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam15346
    Location:114 → 147
    ARGLU; Arginine and glutamate-rich 1
    pfam16014
    Location:290 → 358
    SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

  4. XM_006532986.4 → XP_006533049.1  synergin gamma isoform X9

    UniProtKB/Swiss-Prot
    Q5SV84, Q5SV85, Q6PHT6
    Conserved Domains (3) summary
    cd00052
    Location:235 → 286
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam09606
    Location:30 → 333
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam15346
    Location:113 → 146
    ARGLU; Arginine and glutamate-rich 1

  5. XM_006532981.3 → XP_006533044.1  synergin gamma isoform X4

    UniProtKB/Swiss-Prot
    Q5SV84, Q5SV85, Q6PHT6
    Conserved Domains (4) summary
    cd00052
    Location:399 → 450
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam09606
    Location:14 → 226
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam15346
    Location:98 → 131
    ARGLU; Arginine and glutamate-rich 1
    pfam16014
    Location:453 → 521
    SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

  6. XM_006532982.3 → XP_006533045.1  synergin gamma isoform X5

    UniProtKB/Swiss-Prot
    Q5SV84, Q5SV85, Q6PHT6
    Conserved Domains (4) summary
    cd00052
    Location:398 → 449
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam09606
    Location:14 → 225
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam15346
    Location:97 → 130
    ARGLU; Arginine and glutamate-rich 1
    pfam16014
    Location:452 → 520
    SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001115009.1: Suppressed sequence

    Description
    NM_001115009.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SV85.1 GenPept UniProtKB/Swiss-Prot:Q5SV85

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