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Spns2 SPNS lysolipid transporter 2, sphingosine-1-phosphate [ Mus musculus (house mouse) ]

Gene ID: 216892, updated on 18-Apr-2024

Summary

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Official Symbol
Spns2provided by MGI
Official Full Name
SPNS lysolipid transporter 2, sphingosine-1-phosphateprovided by MGI
Primary source
MGI:MGI:2384936
See related
Ensembl:ENSMUSG00000040447 AllianceGenome:MGI:2384936
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable sphingolipid transporter activity. Acts upstream of or within several processes, including lymph node development; lymphocyte homeostasis; and sphingosine-1-phosphate receptor signaling pathway. Predicted to be located in endosome and plasma membrane. Predicted to be integral component of membrane. Is expressed in jaw bone; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 115. Orthologous to human SPNS2 (sphingolipid transporter 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 39.6), kidney adult (RPKM 31.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B4; 11 44.31 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72342464..72380797, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (72451638..72489976, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene smoothelin-like 2 Neighboring gene STARR-seq mESC enhancer starr_29906 Neighboring gene STARR-positive B cell enhancer ABC_E10683 Neighboring gene STARR-positive B cell enhancer ABC_E8422 Neighboring gene MYB binding protein (P160) 1a Neighboring gene gamma-glutamyltransferase 6 Neighboring gene Spns2 opposite strand Neighboring gene SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative) Neighboring gene STARR-seq mESC enhancer starr_29912 Neighboring gene STARR-positive B cell enhancer ABC_E8423 Neighboring gene predicted gene, 51906 Neighboring gene predicted gene 12712

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Postnatal deletion of Spns2 prevents neuroinflammation without compromising blood vascular functions. Hasan Z, et al. Cell Mol Life Sci, 2022 Oct 5. PMID 36198832
  2. Anomaly of cornea and ocular adnexa in spinster homolog 2 (Spns2) knockout mice. Yasuda S, et al. Ocul Surf, 2022 Oct. PMID 35988880
  3. Lipid transporter Spns2 promotes microglia pro-inflammatory activation in response to amyloid-beta peptide. Zhong L, et al. Glia, 2019 Mar. PMID 30484906, Free PMC Article
  4. S1P transporter SPNS2 regulates proper postnatal retinal morphogenesis. Fang C, et al. FASEB J, 2018 Jul. PMID 29452570
  5. Mouse SPNS2 functions as a sphingosine-1-phosphate transporter in vascular endothelial cells. Hisano Y, et al. PLoS One, 2012. PMID 22723910, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Anomaly of cornea and ocular adnexa in spinster homolog 2 (Spns2) knockout mice.
    Title: Anomaly of cornea and ocular adnexa in spinster homolog 2 (Spns2) knockout mice.
  2. Postnatal deletion of Spns2 prevents neuroinflammation without compromising blood vascular functions.
    Title: Postnatal deletion of Spns2 prevents neuroinflammation without compromising blood vascular functions.
  3. Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and in anaphylactic shock.
    Title: Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and in anaphylactic shock.
  4. SPNS2 enables T cell egress from lymph nodes during an immune response.
    Title: SPNS2 enables T cell egress from lymph nodes during an immune response.
  5. Endothelial Spns2 and ApoM Regulation of Vascular Tone and Hypertension Via Sphingosine-1-Phosphate.
    Title: Endothelial Spns2 and ApoM Regulation of Vascular Tone and Hypertension Via Sphingosine-1-Phosphate.
  6. In summary, these results suggest that Spns2 promotes pro-inflammatory polarization of microglia and may play a crucial role in Alzheimer disease pathogenesis.
    Title: Lipid transporter Spns2 promotes microglia pro-inflammatory activation in response to amyloid-beta peptide.
  7. SPNS2 is essential for proper postnatal retinal morphogenesis.
    Title: S1P transporter SPNS2 regulates proper postnatal retinal morphogenesis.
  8. genome-wide in vivo screen identifies novel host regulators of metastatic colonization, such as Spns2
    Title: Genome-wide in vivo screen identifies novel host regulators of metastatic colonization.
  9. results point to a broad role for Spns2-mediated S1P transport in the initiation and development of adaptive immune related disorders
    Title: Spinster 2, a sphingosine-1-phosphate transporter, plays a critical role in inflammatory and autoimmune diseases.
  10. Spns2 expression by endothelial cells is essential for secretion of lymph S1P, while Spns2 is dispensable for RBC secretion of plasma S1P.
    Title: The transporter Spns2 is required for secretion of lymph but not plasma sphingosine-1-phosphate.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC37865

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables sphingolipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sphingolipid transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sphingolipid transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within B cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within T cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within bone development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lymph node development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lymphocyte homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lymphocyte migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of T cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of eye pigmentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of humoral immune response IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of humoral immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sphingolipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sphingosine-1-phosphate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingosine-1-phosphate receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within sphingosine-1-phosphate receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sphingosine-1-phosphate transporter SPNS2
Names
protein spinster homolog 2
spinster homolog 2
spinster-like protein
spinster2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276383.1 → NP_001263312.1  sphingosine-1-phosphate transporter SPNS2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AL662812
    UniProtKB/TrEMBL
    Q3U1F5
    Conserved Domains (1) summary
    cd17328
    Location:1 → 369
    MFS_spinster_like; Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters

  2. NM_153060.3 → NP_694700.2  sphingosine-1-phosphate transporter SPNS2 isoform 1

    See identical proteins and their annotated locations for NP_694700.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL662812
    Consensus CDS
    CCDS48841.1
    UniProtKB/Swiss-Prot
    B9A1T4, Q5F242, Q8R119, Q91VM4
    UniProtKB/TrEMBL
    Q3U1F5
    Related
    ENSMUSP00000044418.4, ENSMUST00000045303.10
    Conserved Domains (1) summary
    cd17328
    Location:106 → 520
    MFS_spinster_like; Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    72342464..72380797 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532935.3 → XP_006532998.1  sphingosine-1-phosphate transporter SPNS2 isoform X2

    Conserved Domains (1) summary
    cd17328
    Location:106 → 448
    MFS_spinster_like; Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters

  2. XM_017314460.3 → XP_017169949.1  sphingosine-1-phosphate transporter SPNS2 isoform X4

    UniProtKB/Swiss-Prot
    B9A1T4, Q5F242, Q8R119, Q91VM4
    UniProtKB/TrEMBL
    Q3U1F5
    Conserved Domains (1) summary
    cd17328
    Location:106 → 520
    MFS_spinster_like; Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters

  3. XM_006532934.3 → XP_006532997.1  sphingosine-1-phosphate transporter SPNS2 isoform X1

    See identical proteins and their annotated locations for XP_006532997.1

    Conserved Domains (1) summary
    cd17328
    Location:106 → 520
    MFS_spinster_like; Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters

  4. XM_006532936.5 → XP_006532999.1  sphingosine-1-phosphate transporter SPNS2 isoform X3

    Conserved Domains (1) summary
    cd17328
    Location:1 → 369
    MFS_spinster_like; Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters

RNA

  1. XR_388404.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VM4.2 GenPept UniProtKB/Swiss-Prot:Q91VM4

Gene LinkOut

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