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Tekt1 tektin 1 [ Mus musculus (house mouse) ]

Gene ID: 21689, updated on 11-Apr-2024

Summary

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Official Symbol
Tekt1provided by MGI
Official Full Name
tektin 1provided by MGI
Primary source
MGI:MGI:1333819
See related
Ensembl:ENSMUSG00000020799 AllianceGenome:MGI:1333819
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MT14
Summary
Predicted to be involved in cilium assembly and cilium movement involved in cell motility. Located in microtubule cytoskeleton. Is expressed in several structures, including brain; lung; sensory organ; and testis. Orthologous to human TEKT1 (tektin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 66.9) and lung adult (RPKM 2.4) See more
Orthologs
human all
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Genomic context

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Location:
11 B4; 11 44.03 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72235543..72253268, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (72344717..72362442, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene XIAP associated factor 1 Neighboring gene F-box protein 39 Neighboring gene predicted gene, 51867 Neighboring gene predicted gene, 34317 Neighboring gene microRNA 6338 Neighboring gene smoothelin-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The spatial and temporal expression of Tekt1, a mouse tektin C homologue, during spermatogenesis suggest that it is involved in the development of the sperm tail basal body and axoneme. Larsson M, et al. Eur J Cell Biol, 2000 Oct. PMID 11089920
  2. Localization of Tektin 1 at both acrosome and flagella of mouse and bull spermatozoa. Oiki S, et al. Zoolog Sci, 2014 Feb. PMID 24521320
  3. Cloning of canine cDNA encoding tektin. Zhiyong MA, et al. J Vet Med Sci, 2000 Sep. PMID 11039601
  4. Study of Tnp1, Tekt1, and Plzf Genes Expression During an in vitro Three-Dimensional Neonatal Male Mice Testis Culture. Alrahel A, et al. Iran Biomed J, 2018 Jul. PMID 29397043, Free PMC Article
  5. Cep57 protein is required for cytokinesis by facilitating central spindle microtubule organization. He R, et al. J Biol Chem, 2013 May 17. PMID 23569207, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tnp1, Tekt1, and Plzf have essential roles in spermatogenesis and can be expressed during organ culture of testis; with this system, genes can be induced only at the molecular level and not beyond meiosis.
    Title: Study of Tnp1, Tekt1, and Plzf Genes Expression During an in vitro Three-Dimensional Neonatal Male Mice Testis Culture.
  2. These observations suggest another potential role for TEKT1 as a cytoskeletal element in the sperm head, or as a molecule involved in acrosome-related phenomena, such as acrosome reaction.
    Title: Localization of Tektin 1 at both acrosome and flagella of mouse and bull spermatozoa.
  3. Tekt1 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
    Title: Tissue expression patterns identify mouse cilia genes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium movement involved in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in axonemal A tubule inner sheath IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axonemal microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tektin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282006.1 → NP_001268935.1  tektin-1

    See identical proteins and their annotated locations for NP_001268935.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK005801, AV279795
    Consensus CDS
    CCDS36215.1
    UniProtKB/Swiss-Prot
    Q9DAJ2
    UniProtKB/TrEMBL
    Q5NBU4, Q9Z285
    Related
    ENSMUSP00000021155.4, ENSMUST00000021155.4
    Conserved Domains (1) summary
    pfam03148
    Location:16 → 395
    Tektin; Tektin family

  2. NM_001282007.1 → NP_001268936.1  tektin-1

    See identical proteins and their annotated locations for NP_001268936.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AV279795, BC050967
    Consensus CDS
    CCDS36215.1
    UniProtKB/Swiss-Prot
    Q9DAJ2
    UniProtKB/TrEMBL
    Q5NBU4, Q9Z285
    Related
    ENSMUSP00000104142.2, ENSMUST00000108502.8
    Conserved Domains (1) summary
    pfam03148
    Location:16 → 395
    Tektin; Tektin family

  3. NM_011569.3 → NP_035699.2  tektin-1

    See identical proteins and their annotated locations for NP_035699.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AV279795, BB572578, BC098181, BY085053
    Consensus CDS
    CCDS36215.1
    UniProtKB/Swiss-Prot
    Q9DAJ2
    UniProtKB/TrEMBL
    Q5NBU4, Q9Z285
    Related
    ENSMUSP00000104143.3, ENSMUST00000108503.9
    Conserved Domains (1) summary
    pfam03148
    Location:16 → 395
    Tektin; Tektin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    72235543..72253268 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532933.3 → XP_006532996.1  tektin-1 isoform X1

    UniProtKB/TrEMBL
    Q9Z285
    Conserved Domains (1) summary
    pfam03148
    Location:19 → 349
    Tektin; Tektin family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DAJ2.1 GenPept UniProtKB/Swiss-Prot:Q9DAJ2

Gene LinkOut

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