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Spag7 sperm associated antigen 7 [ Mus musculus (house mouse) ]

Gene ID: 216873, updated on 5-Mar-2024

Summary

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Official Symbol
Spag7provided by MGI
Official Full Name
sperm associated antigen 7provided by MGI
Primary source
MGI:MGI:107380
See related
Ensembl:ENSMUSG00000018287 AllianceGenome:MGI:107380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ACRP; FSA-1; Fsa1l; 5730443G10
Summary
Predicted to enable nucleic acid binding activity. Predicted to be located in nucleus. Orthologous to human SPAG7 (sperm associated antigen 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 44.1), CNS E11.5 (RPKM 38.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Spag7 in Genome Data Viewer
Location:
11 B3; 11 43.21 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70554595..70560242, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70663769..70669416, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1422 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:70460970-70461079 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:70461301-70461410 Neighboring gene solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11 Neighboring gene STARR-positive B cell enhancer ABC_E7008 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:70465643-70465931 Neighboring gene ring finger protein 167 Neighboring gene STARR-positive B cell enhancer ABC_E3969 Neighboring gene profilin 1 Neighboring gene enolase 3, beta muscle Neighboring gene STARR-positive B cell enhancer ABC_E62 Neighboring gene calmodulin binding transcription activator 2 Neighboring gene inhibitor of CDK, cyclin A1 interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E7009 Neighboring gene kinesin family member 1C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a fox sperm protein FSA-1. Beaton S, et al. Reprod Fertil Dev, 1994. PMID 7624517
  2. Genetic, physical, and transcript map of the Ltxs1 region of mouse chromosome 11. Watters JW, et al. Genomics, 2001 Apr 15. PMID 11318612
  3. Gene expression in pharyngeal arch 1 during human embryonic development. Cai J, et al. Hum Mol Genet, 2005 Apr 1. PMID 15703188
  4. Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions. Kaput J, et al. Physiol Genomics, 2004 Aug 11. PMID 15306695
  5. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC67704

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sperm-associated antigen 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167669.1 → NP_001161141.1  sperm-associated antigen 7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the CDS, as compared to variant 1. The resulting isoform (2) is shorter but has the same N- and C-termini, as compared to isoform 1.
    Source sequence(s)
    AK042294, AL596117, AV122139, BY261455
    UniProtKB/Swiss-Prot
    Q7TNE3
    Conserved Domains (1) summary
    cd02636
    Location:52 → 99
    R3H_sperm-antigen; R3H domain of a group of metazoan proteins that is related to the sperm-associated antigen 7. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted ...

  2. NM_172561.3 → NP_766149.2  sperm-associated antigen 7 isoform 1

    See identical proteins and their annotated locations for NP_766149.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK042294, AL596117, AV122139
    Consensus CDS
    CCDS24962.1
    UniProtKB/Swiss-Prot
    Q3TM27, Q7TNE3, Q80XJ8, Q8BK16
    Related
    ENSMUSP00000018431.7, ENSMUST00000018431.13
    Conserved Domains (1) summary
    cd02636
    Location:49 → 109
    R3H_sperm-antigen; R3H domain of a group of metazoan proteins that is related to the sperm-associated antigen 7. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    70554595..70560242 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156575.1 → XP_036012468.1  sperm-associated antigen 7 isoform X1

    Conserved Domains (1) summary
    cd02636
    Location:1 → 58
    R3H_sperm-antigen; R3H domain of a group of metazoan proteins that is related to the sperm-associated antigen 7. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TNE3.1 GenPept UniProtKB/Swiss-Prot:Q7TNE3

Gene LinkOut

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