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Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 [ Mus musculus (house mouse) ]

Gene ID: 216859, updated on 5-Mar-2024

Summary

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Official Symbol
Acap1provided by MGI
Official Full Name
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1provided by MGI
Primary source
MGI:MGI:2388270
See related
Ensembl:ENSMUSG00000001588 AllianceGenome:MGI:2388270
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Centb1
Summary
Predicted to enable GTPase activator activity and metal ion binding activity. Predicted to act upstream of or within lipid catabolic process and signal transduction. Predicted to be located in endosome and membrane. Is expressed in several structures, including adipose tissue; alimentary system; brain; genitourinary system; and immune system. Orthologous to human ACAP1 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 113.3), spleen adult (RPKM 55.7) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B3; 11 42.91 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69772393..69786390, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69881566..69895568, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29868 Neighboring gene transmembrane protein 95 Neighboring gene potassium channel tetramerisation domain containing 11 Neighboring gene microRNA 6924 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69708255-69708446 Neighboring gene RIKEN cDNA 2810408A11 gene Neighboring gene STARR-positive B cell enhancer ABC_E7007 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69715057-69715244 Neighboring gene neuralized E3 ubiquitin protein ligase 4 Neighboring gene STARR-positive B cell enhancer ABC_E5243

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ACAP3 regulates neurite outgrowth through its GAP activity specific to Arf6 in mouse hippocampal neurons. Miura Y, et al. Biochem J, 2016 Sep 1. PMID 27330119
  2. Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin. Boles MK, et al. PLoS Genet, 2009 Dec. PMID 20011118, Free PMC Article
  3. Functional genetic analysis of mouse chromosome 11. Kile BT, et al. Nature, 2003 Sep 4. PMID 12955145
  4. Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal. Munger SC, et al. Genes Dev, 2009 Nov 1. PMID 19884258, Free PMC Article
  5. Tie2 regulates endocardial sprouting and myocardial trabeculation. Qu X, et al. JCI Insight, 2019 May 21. PMID 31112136, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Homology

Clone Names

  • MGC25782, MGC47358

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
Names
centaurin, beta 1
cnt-b1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153788.3 → NP_722483.2  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1

    See identical proteins and their annotated locations for NP_722483.2

    Status: PROVISIONAL

    Source sequence(s)
    AL596185, AL845465
    Consensus CDS
    CCDS24919.1
    UniProtKB/Swiss-Prot
    Q3U441, Q571H6, Q8K2H4
    Related
    ENSMUSP00000001631.7, ENSMUST00000001631.7
    Conserved Domains (5) summary
    cd07639
    Location:18 → 217
    BAR_ACAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 1
    COG0666
    Location:551 → 693
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd13250
    Location:268 → 364
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    sd00045
    Location:575 → 602
    ANK; ANK repeat [structural motif]
    cd08852
    Location:405 → 524
    ArfGap_ACAP1; ArfGAP domain of ACAP1 (ArfGAP with Coiled-coil, ANK repeat and PH domains 1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69772393..69786390 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314457.3 → XP_017169946.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X1

    Conserved Domains (3) summary
    cd07639
    Location:18 → 217
    BAR_ACAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 1
    cd13250
    Location:268 → 364
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    cl28907
    Location:405 → 524
    ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2H4.1 GenPept UniProtKB/Swiss-Prot:Q8K2H4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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