Wrap53 WD repeat containing, antisense to Trp53 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wrap53provided by MGI
Official Full Name: WD repeat containing, antisense to Trp53provided by MGI
Primary source: MGI:MGI:2384933
See related: Ensembl:ENSMUSG00000041346 AllianceGenome:MGI:2384933
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Wdr79
Summary: Predicted to enable several functions, including chaperone binding activity; telomerase RNA binding activity; and ubiquitin protein ligase binding activity. Involved in positive regulation of telomerase activity. Predicted to be located in cytosol; nuclear body; and site of double-strand break. Predicted to be part of telomerase holoenzyme complex. Predicted to be active in Cajal body. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 3; colorectal cancer; head and neck squamous cell carcinoma; lung non-small cell carcinoma; and ovarian cancer. Orthologous to human WRAP53 (WD repeat containing antisense to TP53). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 8.1), large intestine adult (RPKM 6.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.81 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (69452580..69471076, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (69561754..69580250, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of WDR79 in non-small cell lung cancer is linked to tumor progression.
Title: Overexpression of WDR79 in non-small cell lung cancer is linked to tumour progression.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

General gene information

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Markers

Trp53 (e-PCR), detects polymorphism
- UniSTS:144673

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables telomerase RNA binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Cajal body organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in Cajal body organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in RNA folding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA repair	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of double-strand break repair via nonhomologous end joining	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of establishment of protein localization to telomere	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomerase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of telomerase activity	ISO Inferred from Sequence Orthology more info
involved_in protein localization to Cajal body	ISO Inferred from Sequence Orthology more info
involved_in scaRNA localization to Cajal body	ISO Inferred from Sequence Orthology more info
involved_in telomerase RNA localization to Cajal body	ISO Inferred from Sequence Orthology more info
involved_in telomere formation via telomerase	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Cajal body	IBA Inferred from Biological aspect of Ancestor more info
located_in Cajal body	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in site of double-strand break	ISO Inferred from Sequence Orthology more info
part_of telomerase holoenzyme complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: telomerase Cajal body protein 1

Names: WD repeat containing, antisense to TP53; WD repeat domain 79; WD repeat-containing protein 79; WD repeat-containing protein WRAP53; WD40 repeat-containing protein antisense to TP53 gene homolog; WD40 repeat-containing protein encoded by RNA antisense to p53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001364769.1 → NP_001351698.1 telomerase Cajal body protein 1

Status: VALIDATED

Source sequence(s)

AL731687

Consensus CDS

CCDS24897.1

UniProtKB/Swiss-Prot

Q8VC51

Conserved Domains (2) summary

sd00039
Location:159 → 204

7WD40; WD40 repeat [structural motif]

cl25539
Location:159 → 465

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_144824.3 → NP_659073.1 telomerase Cajal body protein 1

See identical proteins and their annotated locations for NP_659073.1

Status: VALIDATED

Source sequence(s)

AL731687

Consensus CDS

CCDS24897.1

UniProtKB/Swiss-Prot

Q8VC51

Related

ENSMUSP00000047825.6, ENSMUST00000048139.12

Conserved Domains (2) summary

sd00039
Location:159 → 204

7WD40; WD40 repeat [structural motif]

cl25539
Location:159 → 465

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

69452580..69471076 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532899.5 → XP_006532962.1 telomerase Cajal body protein 1 isoform X1

Conserved Domains (2) summary

sd00039
Location:156 → 203

7WD40; WD40 repeat [structural motif]

cl29593
Location:134 → 254

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006532900.5 → XP_006532963.1 telomerase Cajal body protein 1 isoform X2

Conserved Domains (2) summary

sd00039
Location:156 → 203

7WD40; WD40 repeat [structural motif]

cl29593
Location:134 → 254

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...