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Tecta tectorin alpha [ Mus musculus (house mouse) ]

Gene ID: 21683, updated on 21-Apr-2024

Summary

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Official Symbol
Tectaprovided by MGI
Official Full Name
tectorin alphaprovided by MGI
Primary source
MGI:MGI:109575
See related
Ensembl:ENSMUSG00000037705 AllianceGenome:MGI:109575
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tctna
Summary
An extracellular matrix structural constituent. Predicted to be involved in cell-matrix adhesion. Predicted to act upstream of or within sensory perception of sound. Located in extracellular matrix. Is expressed in inner ear. Used to study autosomal dominant nonsyndromic deafness 12. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 12; autosomal recessive nonsyndromic deafness 21; and sensorineural hearing loss. Orthologous to human TECTA (tectorin alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 2.7), CNS E14 (RPKM 0.4) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A5.1; 9 23.63 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (42240918..42312986, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (42329622..42401690, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36435 Neighboring gene predicted gene, 26272 Neighboring gene STARR-seq mESC enhancer starr_23902 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:42236216-42236386 Neighboring gene predicted gene, 47629 Neighboring gene STARR-seq mESC enhancer starr_23903 Neighboring gene STARR-seq mESC enhancer starr_23904 Neighboring gene STARR-positive B cell enhancer ABC_E9327 Neighboring gene tubulin folding cofactor E-like Neighboring gene predicted gene 16322 Neighboring gene glutamate receptor, ionotropic, kainate 4 Neighboring gene predicted gene, 36590

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The release of surface-anchored α-tectorin, an apical extracellular matrix protein, mediates tectorial membrane organization. Kim DK, et al. Sci Adv, 2019 Nov. PMID 31807709, Free PMC Article
  2. Spontaneous Otoacoustic Emissions in Tecta(Y1870C/+) Mice Reflect Changes in Cochlear Amplification and How It Is Controlled by the Tectorial Membrane. Cheatham MA, et al. eNeuro, 2018 Nov-Dec. PMID 30627650, Free PMC Article
  3. Two-Dimensional Cochlear Micromechanics Measured In Vivo Demonstrate Radial Tuning within the Mouse Organ of Corti. Lee HY, et al. J Neurosci, 2016 Aug 3. PMID 27488636, Free PMC Article
  4. Three deaf mice: mouse models for TECTA-based human hereditary deafness reveal domain-specific structural phenotypes in the tectorial membrane. Legan PK, et al. Hum Mol Genet, 2014 May 15. PMID 24363064, Free PMC Article
  5. Structural and mechanical analysis of tectorial membrane Tecta mutants. Gueta R, et al. Biophys J, 2011 May 18. PMID 21575588, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The release of surface-anchored alpha-tectorin, an apical extracellular matrix protein, mediates tectorial membrane organization.
    Title: The release of surface-anchored α-tectorin, an apical extracellular matrix protein, mediates tectorial membrane organization.
  2. This study demonstrated that the Tecta(Y1870C/+) Mice Reflect Changes in Cochlear Amplification and How It Is Controlled by the Tectorial Membrane.
    Title: Spontaneous Otoacoustic Emissions in Tecta(Y1870C/+) Mice Reflect Changes in Cochlear Amplification and How It Is Controlled by the Tectorial Membrane.
  3. These results highlight the importance of the tectorin-based matrix and epithelial signals for precise collagen organisation in the tectorial membrane.
    Title: A tectorin-based matrix and planar cell polarity genes are required for normal collagen-fibril orientation in the developing tectorial membrane.
  4. Alpha-tectorin and beta-tectorin crosslink type II collagen fibrils and connect the tectorial membrane to the spiral limbus.
    Title: Tectorins crosslink type II collagen fibrils and connect the tectorial membrane to the spiral limbus.
  5. Tecta mutant mice all exhibit an enhanced tendency to have audiogenic seizures in response to white noise stimuli.
    Title: Three deaf mice: mouse models for TECTA-based human hereditary deafness reveal domain-specific structural phenotypes in the tectorial membrane.
  6. CEACAM16 can probably form higher order structures with other tectorial membrane proteins such as alpha-tectorin and beta-tectorin and influences the physical properties of the tectorial membrane
    Title: Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies.
  7. The morphology and mechanical properties of wild-type, heterozygous, and homozygous Tecta tecta membrane, were analysed.
    Title: Structural and mechanical analysis of tectorial membrane Tecta mutants.
  8. In Tecta(Y)(1870C/+) mice, the tectorin content of the tectorial membrane was reduced, as was the content of glycoconjugates reacting with the lectin wheat germ agglutinin.
    Title: Tectorial membrane material properties in Tecta(Y)(1870C/+) heterozygous mice.
  9. The Tecta (A349D/A349D) mouse reveals that missense mutations in Tecta can be recessive and lead to tectorial membrane detachment
    Title: Characterization of a spontaneous, recessive, missense mutation arising in the Tecta gene.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix structural constituent IBA
Inferred from Biological aspect of Ancestor
more info
  
enables extracellular matrix structural constituent IDA
Inferred from Direct Assay
more info
 PubMed 
enables extracellular matrix structural constituent TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within auditory receptor cell stereocilium organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sensory perception of sound TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular matrix TAS
Traceable Author Statement
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-tectorin
Names
[a]-tectorin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324548.2 → NP_001311477.1  alpha-tectorin isoform 2 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC156631
    Consensus CDS
    CCDS85660.1
    UniProtKB/TrEMBL
    B7ZWA6
    Related
    ENSMUSP00000125370.2, ENSMUST00000160940.2
    Conserved Domains (10) summary
    smart00216
    Location:703 → 865
    VWD; von Willebrand factor (vWF) type D domain
    smart00241
    Location:1800 → 2054
    ZP; Zona pellucida (ZP) domain
    smart00539
    Location:98 → 254
    NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
    smart00832
    Location:517 → 591
    C8; This domain contains 8 conserved cysteine residues
    pfam00094
    Location:322 → 478
    VWD; von Willebrand factor type D domain
    pfam00100
    Location:1932 → 2052
    Zona_pellucida; Zona pellucida-like domain
    pfam01826
    Location:597 → 650
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:1298 → 1368
    C8; C8 domain
    pfam14670
    Location:2084 → 2116
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl17735
    Location:652 → 706
    VWC; von Willebrand factor type C domain

  2. NM_001378602.1 → NP_001365531.1  alpha-tectorin isoform 1 prepreprotein precursor

    Status: VALIDATED

    Source sequence(s)
    AC156631
    UniProtKB/Swiss-Prot
    E9QNR3, O08523
    UniProtKB/TrEMBL
    B7ZWA6
    Conserved Domains (9) summary
    smart00216
    Location:703 → 865
    VWD; von Willebrand factor (vWF) type D domain
    smart00241
    Location:1805 → 2059
    ZP; Zona pellucida (ZP) domain
    smart00539
    Location:98 → 254
    NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
    smart00832
    Location:517 → 591
    C8; This domain contains 8 conserved cysteine residues
    cl17735
    Location:652 → 706
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:322 → 478
    VWD; von Willebrand factor type D domain
    pfam08742
    Location:1300 → 1368
    C8; C8 domain
    pfam14670
    Location:2089 → 2121
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cd19941
    Location:597 → 650
    TIL; trypsin inhibitor-like cysteine rich domain

  3. NM_009347.4 → NP_033373.2  alpha-tectorin isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_033373.2

    Status: VALIDATED

    Source sequence(s)
    AC156631
    Consensus CDS
    CCDS23087.1
    UniProtKB/Swiss-Prot
    E9QNR3, O08523
    UniProtKB/TrEMBL
    B7ZWA6
    Related
    ENSMUSP00000040262.8, ENSMUST00000042190.14
    Conserved Domains (9) summary
    smart00216
    Location:703 → 865
    VWD; von Willebrand factor (vWF) type D domain
    smart00241
    Location:1805 → 2059
    ZP; Zona pellucida (ZP) domain
    smart00539
    Location:98 → 254
    NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
    smart00832
    Location:517 → 591
    C8; This domain contains 8 conserved cysteine residues
    cl17735
    Location:652 → 706
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:322 → 478
    VWD; von Willebrand factor type D domain
    pfam08742
    Location:1300 → 1368
    C8; C8 domain
    pfam14670
    Location:2089 → 2121
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cd19941
    Location:597 → 650
    TIL; trypsin inhibitor-like cysteine rich domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    42240918..42312986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154833.1 → XP_036010726.1  alpha-tectorin isoform X1

    UniProtKB/TrEMBL
    B7ZWA6
    Conserved Domains (9) summary
    smart00216
    Location:676 → 838
    VWD; von Willebrand factor (vWF) type D domain
    smart00241
    Location:1778 → 2032
    ZP; Zona pellucida (ZP) domain
    smart00539
    Location:71 → 227
    NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
    smart00832
    Location:490 → 564
    C8; This domain contains 8 conserved cysteine residues
    cl17735
    Location:625 → 679
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:295 → 451
    VWD; von Willebrand factor type D domain
    pfam08742
    Location:1273 → 1341
    C8; C8 domain
    pfam14670
    Location:2062 → 2094
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cd19941
    Location:570 → 623
    TIL; trypsin inhibitor-like cysteine rich domain

  2. XM_006510152.3 → XP_006510215.1  alpha-tectorin isoform X2

    UniProtKB/TrEMBL
    B7ZWA6
    Conserved Domains (7) summary
    smart00216
    Location:703 → 865
    VWD; von Willebrand factor (vWF) type D domain
    smart00539
    Location:98 → 254
    NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
    smart00832
    Location:517 → 591
    C8; This domain contains 8 conserved cysteine residues
    cl17735
    Location:652 → 706
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:322 → 476
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:597 → 650
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:1301 → 1368
    C8; C8 domain

RNA

  1. XR_004935379.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08523.2 GenPept UniProtKB/Swiss-Prot:O08523

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