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Tec tec protein tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 21682, updated on 21-Apr-2024

Summary

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Official Symbol
Tecprovided by MGI
Official Full Name
tec protein tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:98662
See related
Ensembl:ENSMUSG00000029217 AllianceGenome:MGI:98662
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; peptidyl-tyrosine autophosphorylation; and positive regulation of peptidyl-tyrosine phosphorylation. Predicted to act upstream of or within immune system process and phosphorylation. Located in cell-cell junction. Is expressed in several structures, including central nervous system; extraembryonic component; placenta; retina; and spleen. Orthologous to human TEC (tec protein tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 4.6), spleen adult (RPKM 4.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 C3.2; 5 38.44 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (72913061..73025997, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (72755718..72868654, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene NIPA-like domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E3582 Neighboring gene TXK tyrosine kinase Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:73152561-73152781 Neighboring gene STARR-positive B cell enhancer ABC_E4762 Neighboring gene STARR-positive B cell enhancer ABC_E8061 Neighboring gene STARR-positive B cell enhancer ABC_E10324 Neighboring gene STARR-positive B cell enhancer ABC_E8821 Neighboring gene SLAIN motif family, member 2 Neighboring gene predicted gene, 54302 Neighboring gene predicted gene, 54289

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Tyrosine Kinase Tec Regulates Effector Th17 Differentiation, Pathogenicity, and Plasticity in T-Cell-Driven Intestinal Inflammation. Sandner L, et al. Front Immunol, 2021. PMID 35003062, Free PMC Article
  2. Inhibitor of Tec kinase, LFM-A13, decreases pro-inflammatory mediators production in LPS-stimulated RAW264.7 macrophages via NF-κB pathway. Wang F, et al. Oncotarget, 2017 May 23. PMID 28415764, Free PMC Article
  3. Tec kinase stimulates cell survival in transfected Hek293T cells and is regulated by the anti-apoptotic growth factor IGF-I in human neutrophils. Himpe E, et al. Cell Signal, 2013 Mar. PMID 23261945
  4. The protein tyrosine kinase Tec regulates a CD44highCD62L- Th17 subset. Boucheron N, et al. J Immunol, 2010 Nov 1. PMID 20870948
  5. Stress signaling by Tec tyrosine kinase in the ischemic myocardium. Zhang MJ, et al. Am J Physiol Heart Circ Physiol, 2010 Sep. PMID 20543088, Free PMC Article

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Tyrosine Kinase Tec Regulates Effector Th17 Differentiation, Pathogenicity, and Plasticity in T-Cell-Driven Intestinal Inflammation.
    Title: The Tyrosine Kinase Tec Regulates Effector Th17 Differentiation, Pathogenicity, and Plasticity in T-Cell-Driven Intestinal Inflammation.
  2. Inhibition of ITK and RLK attenuated psoriasis-associated signaling pathways, indicating that PRN694 is an effective psoriasis therapeutic.
    Title: ITK and RLK Inhibitor PRN694 Improves Skin Disease in Two Mouse Models of Psoriasis.
  3. Results suggest that Tec kinase involves in acute inflammation process in LPS-stimulated RAW264.7 macrophages cells via NF-kappaB pathway.
    Title: Inhibitor of Tec kinase, LFM-A13, decreases pro-inflammatory mediators production in LPS-stimulated RAW264.7 macrophages via NF-κB pathway.
  4. these data indicate that in mature B cells, Tec and Btk may compete for activation of the Akt signaling pathway, whereby the activating capacity of Btk is limited by the presence of Tec kinase.
    Title: Distinct and Overlapping Functions of TEC Kinase and BTK in B Cell Receptor Signaling.
  5. Tec enhances c-Maf-dependent IL-4 promoter activity. This effect of Tec is counteracted by Ptpn22, which physically interacts with and facilitates tyrosine dephosphorylation of c-Maf thereby attenuating its transcriptional activity.
    Title: Reciprocal regulation of C-Maf tyrosine phosphorylation by Tec and Ptpn22.
  6. identify dectin-1 as the pathogen recognition receptor being required for Syk-dependent Tec activation.
    Title: The non-receptor tyrosine kinase Tec controls assembly and activity of the noncanonical caspase-8 inflammasome.
  7. Btk, Tec, Bmx are required for TLR-dependent signaling in many types of myeloid cells while being tissue-specific.
    Title: The Tec Kinase-Regulated Phosphoproteome Reveals a Mechanism for the Regulation of Inhibitory Signals in Murine Macrophages.
  8. Tec kinase can act as a prosurvival factor and is regulated by IGF-I in human neutrophils through PI(3)K activation.
    Title: Tec kinase stimulates cell survival in transfected Hek293T cells and is regulated by the anti-apoptotic growth factor IGF-I in human neutrophils.
  9. TEC promotes hepatocyte proliferation and regeneration and is involved in Hepatocyte Growth Factor-induced Erk signaling pathway.
    Title: TEC protein tyrosine kinase is involved in the Erk signaling pathway induced by HGF.
  10. our data indicated a critical role for Tec in T cell-intrinsic signaling pathways that regulate the in vivo generation of CD44(high)CD62L(-) effector/memory Th17 populations.
    Title: The protein tyrosine kinase Tec regulates a CD44highCD62L- Th17 subset.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adaptive immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of platelet activation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tyrosine-protein kinase Tec
Names
cytoplasmic tyrosine kinase, Dscr28C related
protein tyrosine kinase TecI
protein tyrosine kinase TecIIA
protein tyrosine kinase TecIIB
protein tyrosine kinase TecIII
protein tyrosine kinase TecIV
NP_001106931.1
NP_001106932.1
NP_001106935.1
NP_038717.2
XP_006503908.1
XP_006503909.1
XP_006503910.1
XP_006503911.1
XP_011239020.1
XP_011239021.1
XP_036020885.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113460.2 → NP_001106931.1  tyrosine-protein kinase Tec isoform a

    See identical proteins and their annotated locations for NP_001106931.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC099698, AK139329, AK168460, CJ047828
    Consensus CDS
    CCDS51516.1
    UniProtKB/Swiss-Prot
    P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3
    UniProtKB/TrEMBL
    Q3U436
    Related
    ENSMUSP00000071836.7, ENSMUST00000071944.13
    Conserved Domains (4) summary
    cd10396
    Location:239 → 346
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11905
    Location:182 → 236
    SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
    cd01238
    Location:7 → 148
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    cd05114
    Location:364 → 623
    PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase

  2. NM_001113461.2 → NP_001106932.1  tyrosine-protein kinase Tec isoform b

    See identical proteins and their annotated locations for NP_001106932.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform b, which lacks an internal segment and is shorter than isoform a.
    Source sequence(s)
    AC099698, AK168452, AK168460, CJ047828
    Consensus CDS
    CCDS51515.1
    UniProtKB/TrEMBL
    Q3TH41, Q8CFK4
    Related
    ENSMUSP00000073509.7, ENSMUST00000073843.13
    Conserved Domains (6) summary
    cd10396
    Location:220 → 324
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd01238
    Location:7 → 148
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    cd05114
    Location:342 → 601
    PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
    pfam00169
    Location:5 → 111
    PH; PH domain
    pfam07714
    Location:347 → 596
    Pkinase_Tyr; Protein tyrosine kinase
    cl17036
    Location:182 → 223
    SH3; Src Homology 3 domain superfamily

  3. NM_001113464.2 → NP_001106935.1  tyrosine-protein kinase Tec isoform a

    See identical proteins and their annotated locations for NP_001106935.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC099698, AK139329, CJ047828
    Consensus CDS
    CCDS51516.1
    UniProtKB/Swiss-Prot
    P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3
    UniProtKB/TrEMBL
    Q3U436
    Related
    ENSMUSP00000109224.2, ENSMUST00000113594.8
    Conserved Domains (4) summary
    cd10396
    Location:239 → 346
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11905
    Location:182 → 236
    SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
    cd01238
    Location:7 → 148
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    cd05114
    Location:364 → 623
    PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase

  4. NM_013689.5 → NP_038717.2  tyrosine-protein kinase Tec isoform c

    See identical proteins and their annotated locations for NP_038717.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site and lacks an alternate in-frame exon in the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform c, which is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC099698, AK133418, AK139329
    UniProtKB/TrEMBL
    Q3TH41
    Conserved Domains (5) summary
    cd10396
    Location:139 → 243
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd05114
    Location:261 → 520
    PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
    pfam07714
    Location:266 → 515
    Pkinase_Tyr; Protein tyrosine kinase
    cl17036
    Location:101 → 142
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:11 → 67
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    72913061..73025997 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503846.5 → XP_006503909.1  tyrosine-protein kinase Tec isoform X1

    See identical proteins and their annotated locations for XP_006503909.1

    UniProtKB/Swiss-Prot
    P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3
    UniProtKB/TrEMBL
    Q3U436
    Conserved Domains (4) summary
    cd10396
    Location:239 → 346
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11905
    Location:182 → 236
    SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
    cd01238
    Location:7 → 148
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    cd05114
    Location:364 → 623
    PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase

  2. XM_011240719.4 → XP_011239021.1  tyrosine-protein kinase Tec isoform X1

    See identical proteins and their annotated locations for XP_011239021.1

    UniProtKB/Swiss-Prot
    P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3
    UniProtKB/TrEMBL
    Q3U436
    Conserved Domains (4) summary
    cd10396
    Location:239 → 346
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11905
    Location:182 → 236
    SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
    cd01238
    Location:7 → 148
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    cd05114
    Location:364 → 623
    PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase

  3. XM_006503845.5 → XP_006503908.1  tyrosine-protein kinase Tec isoform X1

    See identical proteins and their annotated locations for XP_006503908.1

    UniProtKB/Swiss-Prot
    P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3
    UniProtKB/TrEMBL
    Q3U436
    Conserved Domains (4) summary
    cd10396
    Location:239 → 346
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11905
    Location:182 → 236
    SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
    cd01238
    Location:7 → 148
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    cd05114
    Location:364 → 623
    PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase

  4. XM_011240718.3 → XP_011239020.1  tyrosine-protein kinase Tec isoform X1

    See identical proteins and their annotated locations for XP_011239020.1

    UniProtKB/Swiss-Prot
    P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3
    UniProtKB/TrEMBL
    Q3U436
    Conserved Domains (4) summary
    cd10396
    Location:239 → 346
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11905
    Location:182 → 236
    SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
    cd01238
    Location:7 → 148
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    cd05114
    Location:364 → 623
    PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase

  5. XM_006503848.5 → XP_006503911.1  tyrosine-protein kinase Tec isoform X3

    See identical proteins and their annotated locations for XP_006503911.1

    UniProtKB/Swiss-Prot
    P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3
    Conserved Domains (4) summary
    cd10396
    Location:158 → 265
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11905
    Location:101 → 155
    SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
    cd05114
    Location:283 → 542
    PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
    cl17171
    Location:11 → 67
    PH-like; Pleckstrin homology-like domain

  6. XM_006503847.2 → XP_006503910.1  tyrosine-protein kinase Tec isoform X2

    UniProtKB/Swiss-Prot
    P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3
    Conserved Domains (4) summary
    cd10396
    Location:206 → 313
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11905
    Location:149 → 203
    SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
    cd05114
    Location:331 → 590
    PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
    cl17171
    Location:9 → 115
    PH-like; Pleckstrin homology-like domain

  7. XM_036164992.1 → XP_036020885.1  tyrosine-protein kinase Tec isoform X4

    UniProtKB/TrEMBL
    I6L9F0
    Conserved Domains (3) summary
    cd10396
    Location:54 → 161
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11905
    Location:1 → 51
    SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
    cd05114
    Location:179 → 438
    PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P24604.2 GenPept UniProtKB/Swiss-Prot:P24604

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