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Trim58 tripartite motif-containing 58 [ Mus musculus (house mouse) ]

Gene ID: 216781, updated on 5-Mar-2024

Summary

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Official Symbol
Trim58provided by MGI
Official Full Name
tripartite motif-containing 58provided by MGI
Primary source
MGI:MGI:2684862
See related
Ensembl:ENSMUSG00000037124 AllianceGenome:MGI:2684862
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm16; Gm1783
Summary
Enables dynein heavy chain binding activity; dynein intermediate chain binding activity; and ubiquitin protein ligase activity. Involved in several processes, including positive regulation of erythrocyte enucleation; protein ubiquitination; and regulation of nuclear migration along microtubule. Predicted to be active in cytoplasm. Orthologous to human TRIM58 (tripartite motif containing 58). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14.5 (RPKM 8.4), liver E14 (RPKM 6.8) and 2 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B1.3; 11 36.23 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (58531232..58543277)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58640465..58652404)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene LY6/PLAUR domain containing 8 like Neighboring gene olfactory receptor family 11 subfamily L member 3 Neighboring gene predicted gene, 22599 Neighboring gene olfactory receptor family 2 subfamily W member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TRIM58 Restrains Intestinal Mucosal Inflammation by Negatively Regulating TLR2 in Myeloid Cells. Eyking A, et al. J Immunol, 2019 Sep 15. PMID 31383741, Free PMC Article
  2. Trim58 degrades Dynein and regulates terminal erythropoiesis. Thom CS, et al. Dev Cell, 2014 Sep 29. PMID 25241935, Free PMC Article
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein heavy chain binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables dynein intermediate chain binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of erythrocyte enucleation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of nuclear migration along microtubule IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of viral entry into host cell IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase TRIM58
Names
RING-type E3 ubiquitin transferase TRIM58
tripartite motif-containing protein 58
NP_001034136.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039047.2 → NP_001034136.1  E3 ubiquitin-protein ligase TRIM58

    See identical proteins and their annotated locations for NP_001034136.1

    Status: VALIDATED

    Source sequence(s)
    AL645802
    Consensus CDS
    CCDS24738.1
    UniProtKB/Swiss-Prot
    Q5NCC9
    UniProtKB/TrEMBL
    B9EK29
    Related
    ENSMUSP00000074594.5, ENSMUST00000075084.5
    Conserved Domains (3) summary
    smart00336
    Location:90 → 131
    BBOX; B-Box-type zinc finger
    pfam15227
    Location:15 → 58
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cd15816
    Location:291 → 458
    SPRY_PRY_TRIM58; PRY/SPRY domain in tripartite motif-binding protein 58 (TRIM58), also known as BIA2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    58531232..58543277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5NCC9.1 GenPept UniProtKB/Swiss-Prot:Q5NCC9

Gene LinkOut

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