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Tead1 TEA domain family member 1 [ Mus musculus (house mouse) ]

Gene ID: 21676, updated on 9-Dec-2024

Summary

Official Symbol
Tead1provided by MGI
Official Full Name
TEA domain family member 1provided by MGI
Primary source
MGI:MGI:101876
See related
Ensembl:ENSMUSG00000055320 AllianceGenome:MGI:101876
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TEF-1; Tcf13; TEAD-1; mTEF-1; Gtrgeo5; 2610024B07Rik; B230114H05Rik
Summary
Enables DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic organ development; hippo signaling; and transition between fast and slow fiber. Located in nucleus. Part of TEAD-YAP complex. Is expressed in several structures, including central nervous system; early conceptus; embryo mesenchyme; genitourinary system; and tooth. Human ortholog(s) of this gene implicated in Sveinsson chorioretinal atrophy. Orthologous to human TEAD1 (TEA domain transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in bladder adult (RPKM 16.6), heart adult (RPKM 14.4) and 24 other tissues See more
Orthologs
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Genomic context

See Tead1 in Genome Data Viewer
Location:
7 F1; 7 58.8 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (112278563..112505991)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (112679356..112906784)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene parvin, alpha Neighboring gene STARR-seq mESC enhancer starr_19860 Neighboring gene parvin, alpha, opposite strand Neighboring gene STARR-seq mESC enhancer starr_19861 Neighboring gene predicted gene, 24154 Neighboring gene STARR-seq mESC enhancer starr_19863 Neighboring gene predicted gene, 40451 Neighboring gene STARR-seq mESC enhancer starr_19869 Neighboring gene STARR-seq mESC enhancer starr_19880 Neighboring gene STARR-seq mESC enhancer starr_19881 Neighboring gene Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 Neighboring gene ribosomal protein L7A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 27
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to retinoic acid PubMed 
acts_upstream_of_or_within embryonic heart tube morphogenesis PubMed 
involved_in embryonic organ development  
acts_upstream_of_or_within heart development PubMed 
involved_in hippo signaling  
acts_upstream_of_or_within hippo signaling PubMed 
involved_in hippo signaling  
involved_in hippo signaling PubMed 
acts_upstream_of_or_within lateral mesoderm development PubMed 
acts_upstream_of_or_within notochord development PubMed 
acts_upstream_of_or_within paraxial mesoderm development PubMed 
involved_in positive regulation of DNA-templated transcription PubMed 
involved_in positive regulation of DNA-templated transcription  
involved_in positive regulation of cell growth  
involved_in positive regulation of miRNA transcription  
acts_upstream_of_or_within positive regulation of protein serine/threonine kinase activity PubMed 
acts_upstream_of_or_within positive regulation of stem cell population maintenance PubMed 
involved_in positive regulation of transcription by RNA polymerase II PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
involved_in positive regulation of transcription by RNA polymerase II  
involved_in protein-containing complex assembly  
acts_upstream_of_or_within regulation of DNA-templated transcription PubMed 
acts_upstream_of_or_within regulation of cell population proliferation PubMed 
acts_upstream_of_or_within regulation of gene expression PubMed 
involved_in regulation of transcription by RNA polymerase II  
acts_upstream_of_or_within transition between fast and slow fiber PubMed 
Items 1 - 25 of 27
Component Evidence Code Pubs
part_of TEAD-YAP complex PubMed 
part_of TEAD-YAP complex  
located_in nucleoplasm  
located_in nucleus PubMed 
part_of transcription regulator complex  
part_of transcription regulator complex PubMed 
part_of transcription regulator complex PubMed 

General protein information

Preferred Names
transcriptional enhancer factor TEF-1
Names
NTEF-1
TCF-13
transcription factor 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166584.2NP_001160056.2  transcriptional enhancer factor TEF-1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1), which results from the use of a non-AUG (AUU) translation initiation codon.
    Source sequence(s)
    AC104930, AK140307
    Consensus CDS
    CCDS52365.1
    UniProtKB/TrEMBL
    F6QIG2, F6TBI7
    Related
    ENSMUSP00000060671.11, ENSMUST00000059768.18
    Conserved Domains (1) summary
    smart00426
    Location:3097
    TEA; TEA domain
  2. NM_001166585.2NP_001160057.2  transcriptional enhancer factor TEF-1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 5' coding region compared to variant 1 and uses a non-AUG (AUU) start codon for translation initiation. The resulting isoform (3) lacks two internal protein segments compared to variant 1.
    Source sequence(s)
    AC104930, AK140307, BC060138
    Consensus CDS
    CCDS52367.1
    UniProtKB/Swiss-Prot
    P30051
    UniProtKB/TrEMBL
    F7B3M8
    Related
    ENSMUSP00000081755.7, ENSMUST00000084705.13
    Conserved Domains (1) summary
    smart00426
    Location:3097
    TEA; TEA domain
  3. NM_009346.4NP_033372.2  transcriptional enhancer factor TEF-1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1 and uses a non-AUG (AUU) start codon for translation initiation. The resulting isoform (2) lacks an internal protein segment compared to isoform 1.
    Source sequence(s)
    AC104930, AK140307, AK148375
    Consensus CDS
    CCDS52366.1
    UniProtKB/TrEMBL
    F6ZIM6, F7B3M8
    Related
    ENSMUSP00000159345.2, ENSMUST00000239404.2
    Conserved Domains (1) summary
    smart00426
    Location:3097
    TEA; TEA domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    112278563..112505991
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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