Sry sex determining region of Chr Y [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sryprovided by MGI
Official Full Name: sex determining region of Chr Yprovided by MGI
Primary source: MGI:MGI:98660
See related: Ensembl:ENSMUSG00000069036 AllianceGenome:MGI:98660
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tdf; Tdy
Summary: Enables DNA binding activity, bending and DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in male sex determination. Acts upstream of or within male gonad development; negative regulation of gene expression; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including brain; early conceptus; and genitourinary system. Human ortholog(s) of this gene implicated in 46,XX sex reversal 1; 46,XY sex reversal; and 46,XY sex reversal 1. Orthologous to human SRY (sex determining region Y). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: Y; Ypter

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	Y	NC_000087.8 (2662471..2663658, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	Y	NC_000087.7 (2662471..2663658, complement)

Chromosome Y - NC_000087.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SOX9 and SRY binding sites on mouse mXYSRa/Enh13 enhancer redundantly regulate Sox9 expression to varying degrees.
Title: SOX9 and SRY binding sites on mouse mXYSRa/Enh13 enhancer redundantly regulate Sox9 expression to varying degrees.
SRY is a Key Mediator of Sexual Dimorphism in Hepatic Ischemia/Reperfusion Injury.
Title: SRY is a Key Mediator of Sexual Dimorphism in Hepatic Ischemia/Reperfusion Injury.
FGF9 is a downstream target of SRY and sufficient to determine male sex fate in ex vivo XX gonad culture.
Title: FGF9 is a downstream target of SRY and sufficient to determine male sex fate in ex vivo XX gonad culture.
TET2 catalyzes active DNA demethylation of the Sry promoter and enhances its expression.
Title: TET2 catalyzes active DNA demethylation of the Sry promoter and enhances its expression.
The mouse Sry locus harbors a cryptic exon that is essential for male sex determination.
Title: The mouse Sry locus harbors a cryptic exon that is essential for male sex determination.
These results suggest potential molecular causes for germ cell disruption in sex-reversed female mice, thereby providing insights into disorders of sex differentiation in humans.
Title: XY oocytes of sex-reversed females with a Sry mutation deviate from the normal developmental process beyond the mitotic stage†.
Activation of SRY and its downstream Sox9 and PDGFRalpha pathways are commonly involved in male hepatocarcinogenesis, which provides novel insights into gender disparity and sex-specific therapeutic strategies of hepatocellular carcinoma.
Title: Activation of SRY accounts for male-specific hepatocarcinogenesis: Implication in gender disparity of hepatocellular carcinoma.
MAP2K6 functions in mouse testis determination, via positive effects on Sry, and a minor role for MAP2K3.
Title: Genetic Analyses Reveal Functions for MAP2K3 and MAP2K6 in Mouse Testis Determination.
our findings support that males lacking the testis determinant Sry can be fertile and reinforce the notion that Sry does not play a role in mature gonads.
Title: Sry-Independent Overexpression of Sox9 Supports Spermatogenesis and Fertility in the Mouse.
Variations in Usp9y and the number of CAG repeats in Sry are significantly associated with testes weight.
Title: Effect of the Y chromosome on testis weight in mice.

Submit: New GeneRIF Correction See all GeneRIFs (60)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (4) 1 citation
Not Applicable (2) 1 citation
Endonuclease-mediated (13) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sry (e-PCR), detects polymorphism
- UniSTS:465409

Sry (e-PCR), detects polymorphism
- UniSTS:547588

PMC129753P1 (e-PCR)
- UniSTS:270599

Sry (e-PCR), detects polymorphism
- UniSTS:274188

PMC150978P1 (e-PCR)
- UniSTS:271128

Sry (e-PCR), detects polymorphism
- UniSTS:464694

Sry (e-PCR), detects polymorphism
- UniSTS:239196

Sry (e-PCR), detects polymorphism
- UniSTS:239197

Sry (e-PCR), detects polymorphism
- UniSTS:239198

Sry (e-PCR), detects polymorphism
- UniSTS:239199

Sry (e-PCR), detects polymorphism
- UniSTS:256632

Sry (e-PCR), detects polymorphism
- UniSTS:525947

Sry (e-PCR), detects polymorphism
- UniSTS:466048

Sry (e-PCR), detects polymorphism
- UniSTS:466049

Sry (e-PCR), detects polymorphism
- UniSTS:265090

Sry (e-PCR), detects polymorphism
- UniSTS:466050

Sry (e-PCR), detects polymorphism
- UniSTS:256898

Sry (e-PCR), detects polymorphism
- UniSTS:265091

PMC303372P2 (e-PCR)
- UniSTS:272519

NoName (e-PCR)
- UniSTS:485004

PMC303371P2 (e-PCR)
- UniSTS:144792

Sry (e-PCR), detects polymorphism
- UniSTS:144591

Sry (e-PCR), detects polymorphism
- UniSTS:144592

Sry (e-PCR), detects polymorphism
- UniSTS:144593

Sry (e-PCR), detects polymorphism
- UniSTS:144594

Sry (e-PCR), detects polymorphism
- UniSTS:144595

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding, bending	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within male gonad development	IDA Inferred from Direct Assay more info	PubMed
involved_in male gonad development	IDA Inferred from Direct Assay more info	PubMed
involved_in male sex determination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within male sex determination	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of male gonad development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in sex determination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sex determination	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sex differentiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sex-determining region Y protein

Names: testis determining-Y; testis-determining factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011564.1 → NP_035694.1 sex-determining region Y protein

See identical proteins and their annotated locations for NP_035694.1

Status: PROVISIONAL

Source sequence(s)

X67204

Consensus CDS

CCDS30545.1

UniProtKB/TrEMBL

Q2T9H0, Q53WV7

Related

ENSMUSP00000088717.2, ENSMUST00000091178.2

Conserved Domains (1) summary

cd01388
Location:4 → 74

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...