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Dntt deoxynucleotidyltransferase, terminal [ Mus musculus (house mouse) ]

Gene ID: 21673, updated on 5-Mar-2024

Summary

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Official Symbol
Dnttprovided by MGI
Official Full Name
deoxynucleotidyltransferase, terminalprovided by MGI
Primary source
MGI:MGI:98659
See related
Ensembl:ENSMUSG00000025014 AllianceGenome:MGI:98659
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tdt
Summary
Enables DNA nucleotidylexotransferase activity. Acts upstream of or within DNA metabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in bone marrow; ovary; submandibular gland; testis; and thymus. Orthologous to human DNTT (DNA nucleotidylexotransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward thymus adult (RPKM 111.5) See more
Orthologs
human all
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Genomic context

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Location:
19 C3; 19 34.32 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (41017701..41047964)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (41029275..41059525)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C330026H20 gene Neighboring gene STARR-positive B cell enhancer mm9_chr19:41090421-41090722 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:41103805-41103914 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:41105621-41105774 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:41113653-41113854 Neighboring gene ribosomal protein S10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_46143 Neighboring gene STARR-positive B cell enhancer mm9_chr19:41146037-41146338 Neighboring gene STARR-seq mESC enhancer starr_46144 Neighboring gene oligodendrocytic myelin paranodal and inner loop protein Neighboring gene tolloid-like 2 Neighboring gene STARR-seq mESC enhancer starr_46145 Neighboring gene transmembrane 9 superfamily member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular Dynamics Simulations and Structural Analysis to Decipher Functional Impact of a Twenty Residue Insert in the Ternary Complex of Mus musculus TdT Isoform. Mutt E, et al. PLoS One, 2016. PMID 27311013, Free PMC Article
  2. The CDR-H3 repertoire from TdT-deficient adult bone marrow is a close, but not exact, homologue of the CDR-H3 repertoire from perinatal liver. Schelonka RL, et al. J Immunol, 2010 Nov 15. PMID 20956348, Free PMC Article
  3. Terminal deoxynucleotidyltransferase is required for the establishment of private virus-specific CD8+ TCR repertoires and facilitates optimal CTL responses. Kedzierska K, et al. J Immunol, 2008 Aug 15. PMID 18684946, Free PMC Article
  4. Terminal deoxynucleotidyl transferase establishes and broadens antiviral CD8+ T cell immunodominance hierarchies. Haeryfar SM, et al. J Immunol, 2008 Jul 1. PMID 18566432, Free PMC Article
  5. T cell repertoire diversity is required for relapses in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. Fazilleau N, et al. J Immunol, 2007 Apr 15. PMID 17404267

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dntt expression reveals developmental hierarchy and lineage specification of hematopoietic progenitors.
    Title: Dntt expression reveals developmental hierarchy and lineage specification of hematopoietic progenitors.
  2. Molecular dynamics simulations and structural analysis to decipher functional impact of a twenty residue insert in the ternary complex of mus musculus TdT isoform have been reported.
    Title: Molecular Dynamics Simulations and Structural Analysis to Decipher Functional Impact of a Twenty Residue Insert in the Ternary Complex of Mus musculus TdT Isoform.
  3. TdT is essential for the generation of the predominant higher-affinity DEX-responsive J558 clone
    Title: Terminal deoxynucleotidyl transferase is required for an optimal response to the polysaccharide α-1,3 dextran.
  4. The role of TdT ensures enhanced diversity and selection of private T cell receptor repertoires and promotes optimal CD8-positive T cell immunity, both within individuals and across the species as a whole.
    Title: Terminal deoxynucleotidyltransferase is required for the establishment of private virus-specific CD8+ TCR repertoires and facilitates optimal CTL responses.
  5. TdT plays a critical role in the magnitude and breadth of anti-viral T(CD8+) responses toward individual determinants
    Title: Terminal deoxynucleotidyl transferase establishes and broadens antiviral CD8+ T cell immunodominance hierarchies.
  6. tdt may be involved in learning and memory saving.
    Title: Experience-dependent expression of terminal deoxynucleotidyl transferase in mouse brain.
  7. onset of terminal deoxynucleotidyl transferase gene activation during T cell differentiation and thymic ontogeny
    Title: Substantial N diversity is generated in T cell receptor alpha genes at birth despite low levels of terminal deoxynucleotidyl transferase expression in mouse thymus.
  8. Structure-function analysis of proposed domains and motifs for known activity of TdT reveals nonessential role for tumor suppressor BRCA1 C-terminal (BRCT) domain and essential roles for second helix-hairpin-helix motif and entire C terminus of TdT.
    Title: Mutational analysis of terminal deoxynucleotidyltransferase-mediated N-nucleotide addition in V(D)J recombination.
  9. Production of M603-id antibody is TdT dependent, while generation of M167-id antibody is TdT independent.
    Title: The M603 idiotype is lost in the response to phosphocholine in terminal deoxynucleotidyl transferase-deficient mice.
  10. The role of this locus in autoantibody production in MRL/lpr mouse strain, and subsequent development of kidney disease.
    Title: Effect of genetic deficiency of terminal deoxynucleotidyl transferase on autoantibody production and renal disease in MRL/lpr mice.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA nucleotidylexotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA nucleotidylexotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA nucleotidylexotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within DNA modification IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via nonhomologous end joining IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to ATP ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of euchromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
DNA nucleotidylexotransferase
Names
terminal addition enzyme
terminal deoxynucleotidyl transferase
NP_001036693.1
NP_033371.2
XP_036017402.1
XP_036017403.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001043228.1 → NP_001036693.1  DNA nucleotidylexotransferase isoform 2

    See identical proteins and their annotated locations for NP_001036693.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC126608, AF316015, BX639078
    Consensus CDS
    CCDS37984.1
    UniProtKB/Swiss-Prot
    P09838, Q99PD0, Q99PD1
    UniProtKB/TrEMBL
    Q3UZ80
    Related
    ENSMUSP00000107819.2, ENSMUST00000112200.3
    Conserved Domains (3) summary
    cd00141
    Location:166 → 508
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
    smart00292
    Location:32 → 111
    BRCT; breast cancer carboxy-terminal domain
    smart00483
    Location:163 → 509
    POLXc; DNA polymerase X family

  2. NM_009345.2 → NP_033371.2  DNA nucleotidylexotransferase isoform 1

    See identical proteins and their annotated locations for NP_033371.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC126608, AF316014, BX639078
    Consensus CDS
    CCDS29807.1
    UniProtKB/Swiss-Prot
    P09838
    Related
    ENSMUSP00000062078.5, ENSMUST00000051806.12
    Conserved Domains (3) summary
    cd00141
    Location:166 → 528
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
    smart00292
    Location:32 → 111
    BRCT; breast cancer carboxy-terminal domain
    smart00483
    Location:163 → 529
    POLXc; DNA polymerase X family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    41017701..41047964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161509.1 → XP_036017402.1  DNA nucleotidylexotransferase isoform X1

    Conserved Domains (2) summary
    smart00483
    Location:163 → 528
    POLXc; DNA polymerase X family
    cl00038
    Location:31 → 125
    BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains

  2. XM_036161510.1 → XP_036017403.1  DNA nucleotidylexotransferase isoform X2

    Conserved Domains (2) summary
    smart00483
    Location:163 → 508
    POLXc; DNA polymerase X family
    cl00038
    Location:31 → 125
    BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09838.4 GenPept UniProtKB/Swiss-Prot:P09838

Gene LinkOut

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