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Adamts2 ADAM metallopeptidase with thrombospondin type 1 motif 2 [ Mus musculus (house mouse) ]

Gene ID: 216725, updated on 11-Apr-2024

Summary

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Official Symbol
Adamts2provided by MGI
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif 2provided by MGI
Primary source
MGI:MGI:1347356
See related
Ensembl:ENSMUSG00000036545 AllianceGenome:MGI:1347356
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
pNPI; PCINP; PC I-NP; ADAM-TS2; ADAMTS-2; ADAM-TS 2
Summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin repeats) family of proteinases that is involved in the proteolytic processing of procollagens. The encoded protein precursor is proteolytically processed to generate a mature, zinc-dependent enzyme. Mice lacking the encoded protein develop abnormal lungs, fragile skin and male sterility. [provided by RefSeq, Aug 2015]
Expression
Biased expression in ovary adult (RPKM 48.4), subcutaneous fat pad adult (RPKM 22.7) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B1.3; 11 30.78 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (50492912..50698400)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (50602085..50807573)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53702 Neighboring gene predicted gene, 36763 Neighboring gene predicted gene 12198 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:50437439-50437640 Neighboring gene predicted gene, 53703 Neighboring gene STARR-seq mESC enhancer starr_29404 Neighboring gene STARR-seq mESC enhancer starr_29405 Neighboring gene STARR-seq mESC enhancer starr_29406 Neighboring gene predicted gene, 39819 Neighboring gene predicted gene 12199 Neighboring gene STARR-seq mESC enhancer starr_29408 Neighboring gene predicted gene, 51860 Neighboring gene zinc finger protein 354C Neighboring gene zinc finger protein 879

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Critical Role of ADAMTS2 (A Disintegrin and Metalloproteinase With Thrombospondin Motifs 2) in Cardiac Hypertrophy Induced by Pressure Overload. Wang X, et al. Hypertension, 2017 Jun. PMID 28373586
  2. [Preparation of rabbit polyclonal antibody against mouse ADAMTS2]. Fu J, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2016 Mar. PMID 26927563
  3. Determination of the substrate repertoire of ADAMTS2, 3, and 14 significantly broadens their functions and identifies extracellular matrix organization and TGF-β signaling as primary targets. Bekhouche M, et al. FASEB J, 2016 May. PMID 26740262
  4. ADAM metallopeptidase with thrombospondin type 1 motif 2 inactivation reduces the extent and stability of carbon tetrachloride-induced hepatic fibrosis in mice. Kesteloot F, et al. Hepatology, 2007 Nov. PMID 17929299
  5. Spontaneous atopic dermatitis due to immune dysregulation in mice lacking Adamts2 and 14. Dupont L, et al. Matrix Biol, 2018 Sep. PMID 29649548

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function.
    Title: Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function.
  2. ADAMTS-2 significantly contributes to the N-t cleavage and inactivation of Reelin in the postnatal cerebral cortex and hippocampus, but much less in the cerebellum.
    Title: A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum.
  3. Mice lacking Adamts2 and Adamts14 develop spontaneous atopic dermatitis due to immune dysregulation.
    Title: Spontaneous atopic dermatitis due to immune dysregulation in mice lacking Adamts2 and 14.
  4. ADAMTS2 plays a critical role in cardiac hypertrophy induced by pressure overload in mouse model.
    Title: Critical Role of ADAMTS2 (A Disintegrin and Metalloproteinase With Thrombospondin Motifs 2) in Cardiac Hypertrophy Induced by Pressure Overload.
  5. Data show that the high titer and specific rabbit anti-ADAMTS2 antibody has been prepared successfully.
    Title: [Preparation of rabbit polyclonal antibody against mouse ADAMTS2].
  6. There is no significant genotype effect of ADAMTS2 on age, height, weight, BMI or sex on risk of Achilles tendon pathology.
    Title: Polymorphic variation within the ADAMTS2, ADAMTS14, ADAMTS5, ADAM12 and TIMP2 genes and the risk of Achilles tendon pathology: a genetic association study.
  7. Data show that ADAMTS-2 is able to reduce proliferation of endothelial cells, and to induce their retraction and detachment from the substrate resulting in apoptosis.
    Title: ADAMTS-2 functions as anti-angiogenic and anti-tumoral molecule independently of its catalytic activity.
  8. Data show thatincreased mRNA of Lamb3 and Adamts2 and enhanced activities of metalloproteinases MMP1, 2 and 7 in transgenic mice expressing the HLA-DQ8.
    Title: A deregulated immune response to gliadin causes a decreased villus height in DQ8 transgenic mice.
  9. The extent of liver fibrosis is reduced in ADAMTS2-deficient mice in comparison with their wild type littermates.
    Title: ADAM metallopeptidase with thrombospondin type 1 motif 2 inactivation reduces the extent and stability of carbon tetrachloride-induced hepatic fibrosis in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4060, 4732482M10, A430089F14

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within collagen catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within collagen fibril organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within skin development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 2
Names
a disintegrin and metalloproteinase with thrombospondin repeats
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2
procollagen I/II amino propeptide-processing enzyme
procollagen N-endopeptidase
procollagen N-proteinase
NP_783574.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175643.3 → NP_783574.1  A disintegrin and metalloproteinase with thrombospondin motifs 2 preproprotein

    See identical proteins and their annotated locations for NP_783574.1

    Status: REVIEWED

    Source sequence(s)
    AK040370, AL627215, AL645611, AL645639, CJ068037
    Consensus CDS
    CCDS24636.1
    UniProtKB/Swiss-Prot
    Q8C9W3
    UniProtKB/TrEMBL
    A0A5F8MPY1
    Related
    ENSMUSP00000040171.9, ENSMUST00000040523.9
    Conserved Domains (6) summary
    smart00209
    Location:565 → 617
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:267 → 468
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01421
    Location:269 → 471
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:99 → 210
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:724 → 838
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:1064 → 1094
    PLAC; PLAC (protease and lacunin) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    50492912..50698400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001277305.1: Suppressed sequence

    Description
    NM_001277305.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C9W3.2 GenPept UniProtKB/Swiss-Prot:Q8C9W3

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