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Clint1 clathrin interactor 1 [ Mus musculus (house mouse) ]

Gene ID: 216705, updated on 18-Apr-2024

Summary

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Official Symbol
Clint1provided by MGI
Official Full Name
clathrin interactor 1provided by MGI
Primary source
MGI:MGI:2144243
See related
Ensembl:ENSMUSG00000006169 AllianceGenome:MGI:2144243
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Enth; Epn4; C530049I24Rik; F630206G17Rik
Summary
Predicted to enable clathrin binding activity and phospholipid binding activity. Predicted to be involved in endocytosis. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be part of clathrin vesicle coat. Predicted to be active in endosome and plasma membrane. Is expressed in several structures, including alimentary system; craniocervical region bone; respiratory system cartilage; sensory organ; and thoracic segment skeleton. Orthologous to human CLINT1 (clathrin interactor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 47.1), genital fat pad adult (RPKM 44.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B1.1; 11 27.45 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (45742797..45801452)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (45851944..45910625)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA F630206G17 gene Neighboring gene ferritin light chain 1 pseudogene Neighboring gene predicted gene, 53698 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:45665211-45665394 Neighboring gene STARR-seq mESC enhancer starr_29303 Neighboring gene U7 snRNP-specific Sm-like protein LSM11 Neighboring gene STARR-positive B cell enhancer ABC_E5218 Neighboring gene STARR-positive B cell enhancer ABC_E11765 Neighboring gene tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. EpsinR, a target for pyrenocine B, role in endogenous MHC-II-restricted antigen presentation. Shishido T, et al. Eur J Immunol, 2014 Nov. PMID 25196058
  2. Characterization of a gamma-adaptin ear-binding motif in enthoprotin. Wasiak S, et al. FEBS Lett, 2003 Dec 18. PMID 14675752
  3. Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs. Rodríguez-Fraticelli AE, et al. Nat Cell Biol, 2015 Mar. PMID 25706235, Free PMC Article
  4. Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. McIntire JJ, et al. Nat Immunol, 2001 Dec. PMID 11725301
  5. A STUB1 ubiquitin ligase/CHIC2 protein complex negatively regulates the IL-3, IL-5, and GM-CSF cytokine receptor common β chain (CSF2RB) protein stability. Koochaki SHJ, et al. J Biol Chem, 2022 Oct. PMID 36108743, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0171, mKIAA0171

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in clathrin coat assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of clathrin vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
clathrin interactor 1
Names
ENTH domain containing protein
enthoprotin
epsin 4
epsin-related protein
epsinR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045520.5 → NP_001038985.2  clathrin interactor 1 isoform 1

    See identical proteins and their annotated locations for NP_001038985.2

    Status: VALIDATED

    Source sequence(s)
    AL645948
    Consensus CDS
    CCDS36130.1
    UniProtKB/TrEMBL
    Q3UPG6, Q5SUH7
    Related
    ENSMUSP00000104883.2, ENSMUST00000109260.3
    Conserved Domains (2) summary
    cd03571
    Location:23 → 146
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
    pfam15279
    Location:378 → 563
    SOBP; Sine oculis-binding protein

  2. NM_001346760.3 → NP_001333689.1  clathrin interactor 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645948
    Consensus CDS
    CCDS83796.1
    UniProtKB/TrEMBL
    Q3UPG6, Q5SUH6
    Related
    ENSMUSP00000104884.4, ENSMUST00000109261.11

  3. NM_001363484.2 → NP_001350413.1  clathrin interactor 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL645948
    UniProtKB/TrEMBL
    Q3UPG6
    Conserved Domains (3) summary
    cd03571
    Location:23 → 146
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
    pfam09606
    Location:467 → 587
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam13634
    Location:329 → 412
    Nucleoporin_FG; Nucleoporin FG repeat region

  4. NM_001404779.1 → NP_001391708.1  clathrin interactor 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL645948

  5. NM_001404780.1 → NP_001391709.1  clathrin interactor 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL645948

  6. NM_001404781.1 → NP_001391710.1  clathrin interactor 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL645948

  7. NM_001404782.1 → NP_001391711.1  clathrin interactor 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL645948

  8. NM_001404784.1 → NP_001391713.1  clathrin interactor 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL645948

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    45742797..45801452
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99KN9.2 GenPept UniProtKB/Swiss-Prot:Q99KN9

Gene LinkOut

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