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Cep68 centrosomal protein 68 [ Mus musculus (house mouse) ]

Gene ID: 216543, updated on 5-Mar-2024

Summary

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Official Symbol
Cep68provided by MGI
Official Full Name
centrosomal protein 68provided by MGI
Primary source
MGI:MGI:2667663
See related
Ensembl:ENSMUSG00000044066 AllianceGenome:MGI:2667663
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kiaa0582; 6030463E10Rik
Summary
Predicted to enable protein domain specific binding activity and protein kinase binding activity. Predicted to be involved in centriole-centriole cohesion and protein localization to organelle. Predicted to be located in several cellular components, including centriolar satellite; cytosol; and nucleoplasm. Is expressed in several structures, including alimentary system; ganglia; genitourinary system; telencephalon ventricular layer; and vibrissa. Orthologous to human CEP68 (centrosomal protein 68). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E18 (RPKM 13.8), heart adult (RPKM 11.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 A3.1; 11 12.92 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (20177037..20199424, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (20227037..20249424, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28788 Neighboring gene predicted gene, 26253 Neighboring gene RAB1A, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_28789 Neighboring gene STARR-seq mESC enhancer starr_28791 Neighboring gene STARR-positive B cell enhancer ABC_E6955 Neighboring gene predicted gene, 39604 Neighboring gene STARR-seq mESC enhancer starr_28794 Neighboring gene ribosomal proteimn L12-ps2 Neighboring gene solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 Neighboring gene STARR-positive B cell enhancer ABC_E6956

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Comparative transcription map of the wobbler critical region on mouse chromosome 11 and the homologous region on human chromosome 2p13-14. Fuchs S, et al. BMC Genet, 2002 Aug 13. PMID 12174196, Free PMC Article
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC6990

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in centriole-centriole cohesion ISO
Inferred from Sequence Orthology
more info
  
involved_in centrosome cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to organelle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
centrosomal protein of 68 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172260.3 → NP_758464.2  centrosomal protein of 68 kDa

    See identical proteins and their annotated locations for NP_758464.2

    Status: PROVISIONAL

    Source sequence(s)
    AK140820
    Consensus CDS
    CCDS24456.1
    UniProtKB/Swiss-Prot
    Q3US49, Q5SW85, Q8C0D9, Q8R2V0
    UniProtKB/TrEMBL
    Q3ULV4
    Related
    ENSMUSP00000054943.8, ENSMUST00000050611.14
    Conserved Domains (1) summary
    cl02488
    Location:605 → 700
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    20177037..20199424 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C0D9.2 GenPept UniProtKB/Swiss-Prot:Q8C0D9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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