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Arhgap9 Rho GTPase activating protein 9 [ Mus musculus (house mouse) ]

Gene ID: 216445, updated on 21-Apr-2024

Summary

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Official Symbol
Arhgap9provided by MGI
Official Full Name
Rho GTPase activating protein 9provided by MGI
Primary source
MGI:MGI:2143764
See related
Ensembl:ENSMUSG00000040345 AllianceGenome:MGI:2143764
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable GTPase activator activity and phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in regulation of GTPase activity. Predicted to be active in cytoplasm. Is expressed in thymus primordium. Orthologous to human ARHGAP9 (Rho GTPase activating protein 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 29.2), thymus adult (RPKM 26.5) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 D3; 10 74.5 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127157829..127165816)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127321913..127329947)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene DNA-damage inducible transcript 3 Neighboring gene methionine-tRNA synthetase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:126748829-126749012 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10653 Neighboring gene GLI-Kruppel family member GLI1 Neighboring gene STARR-positive B cell enhancer ABC_E10654 Neighboring gene STARR-positive B cell enhancer ABC_E9811 Neighboring gene inhibin beta-E Neighboring gene inhibin beta-C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. WDFY4 is required for cross-presentation in response to viral and tumor antigens. Theisen DJ, et al. Science, 2018 Nov 9. PMID 30409884, Free PMC Article
  2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC37568

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285785.2 → NP_001272714.1  rho GTPase-activating protein 9 isoform 1

    See identical proteins and their annotated locations for NP_001272714.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC114678
    Consensus CDS
    CCDS88101.1
    UniProtKB/TrEMBL
    Q1HDU4
    Related
    ENSMUSP00000151690.2, ENSMUST00000219511.2
    Conserved Domains (5) summary
    cd04403
    Location:438 → 642
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:236 → 349
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:250 → 348
    PH; PH domain
    cl01020
    Location:346 → 432
    ASCH; ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation, ...
    cl17036
    Location:26 → 82
    SH3; Src Homology 3 domain superfamily

  2. NM_001359656.1 → NP_001346585.1  rho GTPase-activating protein 9 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC114678, AK047280, AK049245
    Consensus CDS
    CCDS36079.1
    UniProtKB/TrEMBL
    Q3TIR9, Q8C293, Q8QZW8
    Related
    ENSMUSP00000151574.2, ENSMUST00000219026.2
    Conserved Domains (2) summary
    cd04403
    Location:263 → 467
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:61 → 174
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

  3. NM_001359657.1 → NP_001346586.1  rho GTPase-activating protein 9 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC114678, AK049245, AK083474
    UniProtKB/TrEMBL
    Q3TIR9, Q78T58
    Conserved Domains (2) summary
    cd04403
    Location:196 → 400
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:1 → 107
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

  4. NM_146011.3 → NP_666123.2  rho GTPase-activating protein 9 isoform 2

    See identical proteins and their annotated locations for NP_666123.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC114678, AK049245, BY315862
    Consensus CDS
    CCDS36079.1
    UniProtKB/TrEMBL
    Q3TIR9, Q8C293, Q8QZW8
    Related
    ENSMUSP00000066455.6, ENSMUST00000069548.7
    Conserved Domains (2) summary
    cd04403
    Location:263 → 467
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:61 → 174
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127157829..127165816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513569.5 → XP_006513632.1  rho GTPase-activating protein 9 isoform X1

    Conserved Domains (3) summary
    cd13233
    Location:236 → 349
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    cl02570
    Location:438 → 592
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:26 → 82
    SH3; Src Homology 3 domain superfamily

  2. XM_006513571.5 → XP_006513634.1  rho GTPase-activating protein 9 isoform X2

    See identical proteins and their annotated locations for XP_006513634.1

    UniProtKB/TrEMBL
    Q3TIR9, Q78T58
    Conserved Domains (2) summary
    cd04403
    Location:196 → 400
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:1 → 107
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
Nucleotide Protein Strain
Heading Accession and Version

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