Tspan8 tetraspanin 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tspan8provided by MGI
Official Full Name: tetraspanin 8provided by MGI
Primary source: MGI:MGI:2384918
See related: Ensembl:ENSMUSG00000034127 AllianceGenome:MGI:2384918
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tm4sf3; E330007O21Rik
Summary: Predicted to enable integrin binding activity. Acts upstream of or within regulation of gene expression and spermatogenesis. Located in cell surface. Orthologous to human TSPAN8 (tetraspanin 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 83.3), bladder adult (RPKM 27.8) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D2; 10 63.51 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (115652722..115685798)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (115816817..115849893)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tetraspanin Tspan8 restrains interferon signaling to stabilize intestinal epithelium by directing endocytosis of interferon receptor.
Title: Tetraspanin Tspan8 restrains interferon signaling to stabilize intestinal epithelium by directing endocytosis of interferon receptor.
Extracellular vesicle tetraspanin-8 level predicts distant metastasis in non-small cell lung cancer after concurrent chemoradiation.
Title: Extracellular vesicle tetraspanin-8 level predicts distant metastasis in non-small cell lung cancer after concurrent chemoradiation.
Single nucleotide polymorphism in TSPAN8 gene is associated with pathogenesis of bipolar disorder.
Title: The regulation of tetraspanin 8 gene expression-A potential new mechanism in the pathogenesis of bipolar disorder.
Transplantation studies provided definitive evidence that a TSPAN8-high subpopulation is enriched for spermatogonial stem cells.
Title: TSPAN8 Expression Distinguishes Spermatogonial Stem Cells in the Prepubertal Mouse Testis.
results argue for a role for Tspan8 in body-weight regulation in males, but do not show differences in T2D-associated traits that were anticipated from previous human genome-wide association studies.
Title: Reduced body weight in male Tspan8-deficient mice.
Results suggest that alterations in gene expression of Gata6, Tspan8, S100a8, and Lmo2 may act via novel pathways that play functionally important roles in Men1-associated tumor progression.
Title: Alterations in gene expression in MEN1-associated insulinoma development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in negative regulation of blood coagulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within spermatogenesis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tetraspanin-8

Names: transmembrane 4 superfamily member 3; tspan-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168679.1 → NP_001162150.1 tetraspanin-8

See identical proteins and their annotated locations for NP_001162150.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

AC153364, AK077301, DV060937, DV065030

Consensus CDS

CCDS24181.1

UniProtKB/Swiss-Prot

Q8R3G9

Related

ENSMUSP00000136645.2, ENSMUST00000179196.3

Conserved Domains (1) summary

pfam00335
Location:8 → 228

Tetraspannin; Tetraspanin family
NM_001168680.1 → NP_001162151.1 tetraspanin-8

See identical proteins and their annotated locations for NP_001162151.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

AC153364, AK077301, DV060937

Consensus CDS

CCDS24181.1

UniProtKB/Swiss-Prot

Q8R3G9

Related

ENSMUSP00000079463.4, ENSMUST00000080630.11

Conserved Domains (1) summary

pfam00335
Location:8 → 228

Tetraspannin; Tetraspanin family
NM_146010.2 → NP_666122.1 tetraspanin-8

See identical proteins and their annotated locations for NP_666122.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.

Source sequence(s)

AC126270, AC153364, AK077301, DV060937

Consensus CDS

CCDS24181.1

UniProtKB/Swiss-Prot

Q8R3G9

Related

ENSMUSP00000049243.8, ENSMUST00000035563.15

Conserved Domains (1) summary

pfam00335
Location:8 → 228

Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

115652722..115685798

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513542.2 → XP_006513605.1 tetraspanin-8 isoform X1

See identical proteins and their annotated locations for XP_006513605.1

UniProtKB/Swiss-Prot

Q8R3G9

Conserved Domains (1) summary

pfam00335
Location:8 → 228

Tetraspannin; Tetraspanin family
XM_006513543.5 → XP_006513606.1 tetraspanin-8 isoform X2

Conserved Domains (1) summary

cd03154
Location:40 → 138

TM4SF3_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...