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Zfc3h1 zinc finger, C3H1-type containing [ Mus musculus (house mouse) ]

Gene ID: 216345, updated on 5-Mar-2024

Summary

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Official Symbol
Zfc3h1provided by MGI
Official Full Name
zinc finger, C3H1-type containingprovided by MGI
Primary source
MGI:MGI:2446143
See related
Ensembl:ENSMUSG00000034163 AllianceGenome:MGI:2446143
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Psrc2; Ccdc131
Summary
Predicted to be part of exosome (RNase complex). Predicted to be active in nucleus. Orthologous to human ZFC3H1 (zinc finger C3H1-type containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 11.2), CNS E14 (RPKM 10.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 D2; 10 63.51 cM
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (115220691..115268677)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (115384799..115432772)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27939 Neighboring gene STARR-seq mESC enhancer starr_27942 Neighboring gene transmembrane protein 19 Neighboring gene soc-2 (suppressor of clear) homolog pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1128 Neighboring gene THAP domain containing, apoptosis associated protein 2 Neighboring gene predicted gene, 53633 Neighboring gene leucine rich repeat containing G protein coupled receptor 5 Neighboring gene STARR-positive B cell enhancer mm9_chr10:114916114-114916415 Neighboring gene STARR-seq mESC enhancer starr_27944 Neighboring gene RIKEN cDNA A930009A15 gene Neighboring gene ribosomal protein S3A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
  2. Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3. Villegas F, et al. Cell Stem Cell, 2019 Feb 7. PMID 30595499
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
part_of exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exosome (RNase complex) ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger C3H1 domain-containing protein
Names
coiled-coil domain containing 131
proline/serine-rich coiled-coil 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033261.2 → NP_001028433.2  zinc finger C3H1 domain-containing protein

    See identical proteins and their annotated locations for NP_001028433.2

    Status: VALIDATED

    Source sequence(s)
    AK145652, AK172969
    Consensus CDS
    CCDS36062.1
    UniProtKB/TrEMBL
    B2RT41, Q6A049
    Related
    ENSMUSP00000044069.9, ENSMUST00000036044.9
    Conserved Domains (3) summary
    sd00006
    Location:1607 → 1633
    TPR; TPR repeat [structural motif]
    pfam10650
    Location:1189 → 1207
    zf-C3H1; Putative zinc-finger domain
    pfam13414
    Location:1607 → 1670
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    115220691..115268677
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513538.5 → XP_006513601.1  zinc finger C3H1 domain-containing protein isoform X1

    UniProtKB/TrEMBL
    Q6A049
    Conserved Domains (5) summary
    TIGR02168
    Location:738 → 1010
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02917
    Location:1354 → 1682
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:1608 → 1634
    TPR; TPR repeat [structural motif]
    pfam02463
    Location:201 → 998
    SMC_N; RecF/RecN/SMC N terminal domain
    pfam10650
    Location:1189 → 1209
    zf-C3H1; Putative zinc-finger domain

  2. XM_006513540.5 → XP_006513603.1  zinc finger C3H1 domain-containing protein isoform X3

    UniProtKB/TrEMBL
    Q6A049
    Conserved Domains (5) summary
    TIGR02168
    Location:738 → 1010
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02917
    Location:1354 → 1682
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:1608 → 1634
    TPR; TPR repeat [structural motif]
    pfam02463
    Location:201 → 998
    SMC_N; RecF/RecN/SMC N terminal domain
    pfam10650
    Location:1189 → 1209
    zf-C3H1; Putative zinc-finger domain

  3. XM_006513539.5 → XP_006513602.1  zinc finger C3H1 domain-containing protein isoform X2

    UniProtKB/TrEMBL
    Q6A049
    Conserved Domains (5) summary
    TIGR02168
    Location:737 → 1009
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02917
    Location:1353 → 1681
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:1607 → 1633
    TPR; TPR repeat [structural motif]
    pfam02463
    Location:201 → 997
    SMC_N; RecF/RecN/SMC N terminal domain
    pfam10650
    Location:1188 → 1208
    zf-C3H1; Putative zinc-finger domain

  4. XM_017313907.3 → XP_017169396.1  zinc finger C3H1 domain-containing protein isoform X5

    UniProtKB/TrEMBL
    Q6P7T8
    Conserved Domains (3) summary
    TIGR02917
    Location:408 → 736
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:662 → 688
    TPR; TPR repeat [structural motif]
    pfam10650
    Location:243 → 263
    zf-C3H1; Putative zinc-finger domain

  5. XM_036155758.1 → XP_036011651.1  zinc finger C3H1 domain-containing protein isoform X4

    UniProtKB/TrEMBL
    Q6P7T8
    Conserved Domains (3) summary
    TIGR02917
    Location:408 → 736
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:662 → 688
    TPR; TPR repeat [structural motif]
    pfam10650
    Location:243 → 262
    zf-C3H1; Putative zinc-finger domain

RNA

  1. XR_003948675.2 RNA Sequence

  2. XR_003948676.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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