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Eea1 early endosome antigen 1 [ Mus musculus (house mouse) ]

Gene ID: 216238, updated on 13-Apr-2024

Summary

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Official Symbol
Eea1provided by MGI
Official Full Name
early endosome antigen 1provided by MGI
Primary source
MGI:MGI:2442192
See related
Ensembl:ENSMUSG00000036499 AllianceGenome:MGI:2442192
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZFYVE2; A430109M19Rik; B230358H09Rik
Summary
Predicted to enable 1-phosphatidylinositol binding activity; GTP-dependent protein binding activity; and protein homodimerization activity. Predicted to be involved in endocytosis; vesicle fusion; and viral RNA genome replication. Located in axonal spine and early endosome. Part of serine-pyruvate aminotransferase complex. Is expressed in cerebellum Purkinje cell layer; genitourinary system; and pancreatic acinus. Orthologous to human EEA1 (early endosome antigen 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 5.5), placenta adult (RPKM 5.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C2; 10 49.59 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (95776525..95881380)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (95940663..96045518)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33377 Neighboring gene predicted gene, 33543 Neighboring gene STARR-positive B cell enhancer ABC_E2335 Neighboring gene STARR-seq mESC enhancer starr_27659 Neighboring gene STARR-seq mESC enhancer starr_27660 Neighboring gene STARR-seq mESC enhancer starr_27661 Neighboring gene STARR-seq mESC enhancer starr_27662 Neighboring gene STARR-positive B cell enhancer ABC_E2962 Neighboring gene predicted gene, 24433 Neighboring gene STARR-seq mESC enhancer starr_27664 Neighboring gene predicted gene, 49817 Neighboring gene STARR-seq mESC enhancer starr_27665 Neighboring gene STARR-seq mESC enhancer starr_27666 Neighboring gene STARR-seq mESC enhancer starr_27667 Neighboring gene predicted gene, 48425

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Filamentous morphology of bacteria delays the timing of phagosome morphogenesis in macrophages. Prashar A, et al. J Cell Biol, 2013 Dec 23. PMID 24368810, Free PMC Article
  2. Early Endosome Antigen 1 (EEA1) decreases in macrophages infected with Paracoccidioides brasiliensis. Voltan AR, et al. Med Mycol, 2013 Oct. PMID 23566224
  3. EEA1 restores homeostatic synaptic plasticity in hippocampal neurons from Rett syndrome mice. Xu X, et al. J Physiol, 2017 Aug 15. PMID 28621434, Free PMC Article
  4. Single-step protease cleavage elution for identification of protein-protein interactions from GST pull-down and mass spectrometry. Luo L, et al. Proteomics, 2014 Jan. PMID 24259493
  5. Francisella tularensis invasion of lung epithelial cells. Craven RR, et al. Infect Immun, 2008 Jul. PMID 18426871, Free PMC Article

See all (93) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Early endosome autoantigen 1 regulates IL-1beta release upon caspase-1 activation independently of gasdermin D membrane permeabilization.
    Title: Early endosome autoantigen 1 regulates IL-1β release upon caspase-1 activation independently of gasdermin D membrane permeabilization.
  2. larger autophagic vacuoles that colocalize with early endosome antigen 1 (EEA1) but not with lysosomal-associated membrane protein (LAMP)-1 were much more frequently formed in Rab7(Deltapan) pancreatic acinar cells.
    Title: Disruption of Small GTPase Rab7 Exacerbates the Severity of Acute Pancreatitis in Experimental Mouse Models.
  3. Our characterization of the role of EEA1 during homeostatic synaptic plasticity in Mecp2 KO neurons provides potentially novel targets of intervention for improving hippocampal function in Rett Syndrome individuals.
    Title: EEA1 restores homeostatic synaptic plasticity in hippocampal neurons from Rett syndrome mice.
  4. In the present study, decreased expression of EEA1 as well as the rearrangement of the actin was observed when Paracoccidioides brasiliensis was internalized in macrophages.
    Title: Early Endosome Antigen 1 (EEA1) decreases in macrophages infected with Paracoccidioides brasiliensis.
  5. F. tularensis-containing endosomes associated with early endosome antigen 1 (EEA1) followed by lysosome-associated membrane protein 1 (LAMP-1), with peak coassociation frequencies occurring at 30 and 120 min postinoculation, respectively.
    Title: Francisella tularensis invasion of lung epithelial cells.
  6. Tec vesicles have a membrane proximal location and overlap with the tyrosine kinase Lck, the Tec substrate PLC-gamma1, and the early endosomal antigen 1 marker EEA1
    Title: Dynamic regulation of Tec kinase localization in membrane-proximal vesicles of a T cell clone revealed by total internal reflection fluorescence and confocal microscopy.
  7. phosphomimetic mutation of Thr-1392 in EEA1 can bypass the requirement for p38alpha in mu opioid receptor endocytosis
    Title: Phosphorylation of EEA1 by p38 MAP kinase regulates mu opioid receptor endocytosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chemical synaptic transmission, postsynaptic IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in modulation by host of viral process ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle fusion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axonal spine IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
  
part_of serine-pyruvate aminotransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
early endosome antigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001932.3 → NP_001001932.1  early endosome antigen 1

    See identical proteins and their annotated locations for NP_001001932.1

    Status: VALIDATED

    Source sequence(s)
    AC115970, BB638838, BC075637
    Consensus CDS
    CCDS36042.1
    UniProtKB/Swiss-Prot
    Q6DIC2, Q8BL66
    Related
    ENSMUSP00000061493.7, ENSMUST00000053484.8
    Conserved Domains (3) summary
    cd15730
    Location:1347 → 1409
    FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins
    pfam01576
    Location:107 → 1119
    Myosin_tail_1; Myosin tail
    pfam07851
    Location:909 → 988
    TMPIT; TMPIT-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    95776525..95881380
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513522.5 → XP_006513585.1  early endosome antigen 1 isoform X1

    Conserved Domains (3) summary
    COG1196
    Location:504 → 1346
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:130 → 794
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15730
    Location:1394 → 1456
    FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins

  2. XM_006513523.5 → XP_006513586.1  early endosome antigen 1 isoform X2

    Conserved Domains (3) summary
    COG1196
    Location:499 → 1341
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:130 → 789
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15730
    Location:1389 → 1451
    FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins

  3. XM_006513524.5 → XP_006513587.1  early endosome antigen 1 isoform X3

    Conserved Domains (3) summary
    COG1196
    Location:462 → 1304
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:88 → 752
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15730
    Location:1352 → 1414
    FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins

  4. XM_006513525.5 → XP_006513588.1  early endosome antigen 1 isoform X4

    Conserved Domains (3) summary
    COG1196
    Location:342 → 1184
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:19 → 622
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15730
    Location:1232 → 1294
    FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BL66.2 GenPept UniProtKB/Swiss-Prot:Q8BL66

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