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Abhd17a abhydrolase domain containing 17A [ Mus musculus (house mouse) ]

Gene ID: 216169, updated on 11-Apr-2024

Summary

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Official Symbol
Abhd17aprovided by MGI
Official Full Name
abhydrolase domain containing 17Aprovided by MGI
Primary source
MGI:MGI:106388
See related
Ensembl:ENSMUSG00000003346 AllianceGenome:MGI:106388
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam108a; D10Bwg1364e; 1700013O15Rik
Summary
Predicted to enable palmitoyl-(protein) hydrolase activity. Predicted to be involved in several processes, including negative regulation of protein localization to microtubule; positive regulation of protein localization to endosome; and protein depalmitoylation. Predicted to be located in nuclear speck; postsynaptic density; and recycling endosome membrane. Predicted to be active in endosome membrane and plasma membrane. Orthologous to human ABHD17A (abhydrolase domain containing 17A, depalmitoylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 251.7), adrenal adult (RPKM 194.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 39.72 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80419483..80426199, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80583649..80590341, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr10:80032416-80032717 Neighboring gene Kruppel-like transcription factor 16 Neighboring gene STARR-positive B cell enhancer ABC_E11446 Neighboring gene predicted gene, 26710 Neighboring gene STARR-positive B cell enhancer ABC_E2950 Neighboring gene STARR-positive B cell enhancer ABC_E6883 Neighboring gene secretory carrier membrane protein 4 Neighboring gene adenosine deaminase, tRNA-specific 3 Neighboring gene microRNA 6912

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Comparative maps of human 19p13.3 and mouse chromosome 10 allow identification of sequences at evolutionary breakpoints. Puttagunta R, et al. Genome Res, 2000 Sep. PMID 10984455, Free PMC Article
  2. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC11699, MGC90979

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyl-(protein) hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables palmitoyl-(protein) hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of NLRP3 inflammasome complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein localization to microtubule ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to endosome ISO
Inferred from Sequence Orthology
more info
  
involved_in protein depalmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein depalmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynapse organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of postsynapse organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha/beta hydrolase domain-containing protein 17A
Names
abhydrolase domain-containing protein 17A
abhydrolase domain-containing protein FAM108A
family with sequence similarity 108, member A
mFLJ00358 protein
protein ABHD17A
NP_663396.1
XP_006513567.1
XP_017169383.1
XP_030100883.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145421.2 → NP_663396.1  alpha/beta hydrolase domain-containing protein 17A

    See identical proteins and their annotated locations for NP_663396.1

    Status: VALIDATED

    Source sequence(s)
    AC152058
    Consensus CDS
    CCDS24027.1
    UniProtKB/Swiss-Prot
    Q5DU54, Q99JW1
    Related
    ENSMUSP00000003436.6, ENSMUST00000003436.12
    Conserved Domains (1) summary
    COG1073
    Location:113 → 305
    FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80419483..80426199 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513504.3 → XP_006513567.1  alpha/beta hydrolase domain-containing protein 17A isoform X2

    Conserved Domains (1) summary
    COG1073
    Location:117 → 240
    FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]

  2. XM_017313894.3 → XP_017169383.1  alpha/beta hydrolase domain-containing protein 17A isoform X1

    UniProtKB/Swiss-Prot
    Q5DU54, Q99JW1
    Conserved Domains (1) summary
    COG1073
    Location:113 → 305
    FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]

  3. XM_030245023.2 → XP_030100883.1  alpha/beta hydrolase domain-containing protein 17A isoform X2

    Conserved Domains (1) summary
    COG1073
    Location:117 → 240
    FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99JW1.1 GenPept UniProtKB/Swiss-Prot:Q99JW1

Gene LinkOut

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