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Sbno2 strawberry notch 2 [ Mus musculus (house mouse) ]

Gene ID: 216161, updated on 5-Mar-2024

Summary

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Official Symbol
Sbno2provided by MGI
Official Full Name
strawberry notch 2provided by MGI
Primary source
MGI:MGI:2448490
See related
Ensembl:ENSMUSG00000035673 AllianceGenome:MGI:2448490
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sno; Stno; F730040C21
Summary
Predicted to enable chromatin DNA binding activity and histone binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipopolysaccharide; and macrophage activation involved in immune response. Acts upstream of or within several processes, including bone mineralization; bone trabecula morphogenesis; and osteoclast fusion. Predicted to be active in nucleus. Is expressed in submandibular gland primordium and vibrissa. Orthologous to human SBNO2 (strawberry notch homolog 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 34.9), spleen adult (RPKM 33.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Sbno2 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79892826..79941942, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80056992..80106108, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6880 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide E Neighboring gene STARR-seq mESC enhancer starr_27262 Neighboring gene STARR-positive B cell enhancer ABC_E900 Neighboring gene glutathione peroxidase 4 Neighboring gene STARR-seq mESC enhancer starr_27263 Neighboring gene STARR-seq mESC enhancer starr_27266 Neighboring gene serine/threonine kinase 11 Neighboring gene calcium channel, voltage-dependent, beta subunit associated regulatory protein Neighboring gene STARR-positive B cell enhancer ABC_E11444 Neighboring gene STARR-positive B cell enhancer ABC_E1806 Neighboring gene ATP synthase F1 subunit delta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Strawberry notch homolog 2 regulates the response to interleukin-6 in the central nervous system. Syme TE, et al. J Neuroinflammation, 2022 May 27. PMID 35624480, Free PMC Article
  2. Strawberry notch homolog 2 is a novel inflammatory response factor predominantly but not exclusively expressed by astrocytes in the central nervous system. Grill M, et al. Glia, 2015 Oct. PMID 25903009, Free PMC Article
  3. A mouse homologue of Strawberry Notch is transcriptionally regulated by Reelin signal. Baba K, et al. Biochem Biophys Res Commun, 2006 Dec 1. PMID 17045962
  4. Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway. El Kasmi KC, et al. J Immunol, 2007 Dec 1. PMID 18025162
  5. Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP. Maruyama K, et al. J Exp Med, 2013 Sep 23. PMID 23980096, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SBNO2 provides negative feedback to the transcriptional response to IL-6
    Title: Strawberry notch homolog 2 regulates the response to interleukin-6 in the central nervous system.
  2. The findings of this study are consistent with SBNO2 functioning as an acute inflammatory response gene in astrocytes as well as other cells in the CNS.
    Title: Strawberry notch homolog 2 is a novel inflammatory response factor predominantly but not exclusively expressed by astrocytes in the central nervous system.
  3. Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP.
    Title: Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP.
  4. The SBNO2 is component of the pathways that contribute to the downstream anti-inflammatory effects of IL-10.
    Title: Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within bone mineralization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within bone trabecula morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to interleukin-11 IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to interleukin-6 IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to interleukin-6 IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to interleukin-6 ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to leukemia inhibitory factor IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in macrophage activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in macrophage activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in macrophage activation involved in immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multinuclear osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ossification IEA
Inferred from Electronic Annotation
more info
  
involved_in osteoclast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within osteoclast fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein strawberry notch homolog 2
Names
strawberry notch homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359635.1 → NP_001346564.1  protein strawberry notch homolog 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK149806, BC032886, BC056369
    UniProtKB/TrEMBL
    A0A1W2P7W8
    Related
    ENSMUSP00000151854.2, ENSMUST00000218630.2
    Conserved Domains (3) summary
    pfam13871
    Location:726 → 1004
    Helicase_C_4; C-terminal domain on Strawberry notch homolog
    pfam13872
    Location:212 → 500
    AAA_34; P-loop containing NTP hydrolase pore-1
    pfam17061
    Location:34 → 165
    PARM

  2. NM_001359636.1 → NP_001346565.1  protein strawberry notch homolog 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    BC064113
    UniProtKB/TrEMBL
    A0A1W2P6Y8
    Related
    ENSMUST00000217876.2
    Conserved Domains (1) summary
    pfam13872
    Location:138 → 426
    AAA_34; P-loop containing NTP hydrolase pore-1

  3. NM_001359637.1 → NP_001346566.1  protein strawberry notch homolog 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC159999, BC056369
    UniProtKB/TrEMBL
    A0A1W2P7W9
    Related
    ENSMUST00000217683.2

  4. NM_183426.2 → NP_906271.1  protein strawberry notch homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_906271.1

    Status: VALIDATED

    Source sequence(s)
    BC032886, BC056369
    Consensus CDS
    CCDS24008.1
    UniProtKB/Swiss-Prot
    Q3UE14, Q6P3A3, Q70X02, Q7TNB8
    UniProtKB/TrEMBL
    A0A1W2P7W8
    Related
    ENSMUSP00000041635.8, ENSMUST00000042771.8
    Conserved Domains (3) summary
    pfam13871
    Location:726 → 1004
    Helicase_C_4; C-terminal domain on Strawberry notch homolog
    pfam13872
    Location:212 → 500
    AAA_34; P-loop containing NTP hydrolase pore-1
    pfam17061
    Location:34 → 165
    PARM

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    79892826..79941942 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513494.1 → XP_006513557.1  protein strawberry notch homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_006513557.1

    UniProtKB/Swiss-Prot
    Q3UE14, Q6P3A3, Q70X02, Q7TNB8
    UniProtKB/TrEMBL
    A0A1W2P7W8
    Conserved Domains (3) summary
    pfam13871
    Location:726 → 1004
    Helicase_C_4; C-terminal domain on Strawberry notch homolog
    pfam13872
    Location:212 → 500
    AAA_34; P-loop containing NTP hydrolase pore-1
    pfam17061
    Location:34 → 165
    PARM

  2. XM_036155737.1 → XP_036011630.1  protein strawberry notch homolog 2 isoform X5

    UniProtKB/TrEMBL
    A0A1W2P7W8
    Conserved Domains (3) summary
    pfam13871
    Location:726 → 960
    Helicase_C_4; C-terminal domain on Strawberry notch homolog
    pfam13872
    Location:212 → 500
    AAA_34; P-loop containing NTP hydrolase pore-1
    pfam17061
    Location:34 → 165
    PARM

  3. XM_036155736.1 → XP_036011629.1  protein strawberry notch homolog 2 isoform X4

    UniProtKB/TrEMBL
    A0A1W2P7W8
    Conserved Domains (3) summary
    pfam13871
    Location:726 → 960
    Helicase_C_4; C-terminal domain on Strawberry notch homolog
    pfam13872
    Location:212 → 500
    AAA_34; P-loop containing NTP hydrolase pore-1
    pfam17061
    Location:34 → 165
    PARM

  4. XM_006513495.3 → XP_006513558.1  protein strawberry notch homolog 2 isoform X2

    See identical proteins and their annotated locations for XP_006513558.1

    UniProtKB/TrEMBL
    A0A1W2P7W8
    Conserved Domains (3) summary
    pfam13871
    Location:726 → 1004
    Helicase_C_4; C-terminal domain on Strawberry notch homolog
    pfam13872
    Location:212 → 500
    AAA_34; P-loop containing NTP hydrolase pore-1
    pfam17061
    Location:34 → 165
    PARM

  5. XM_006513492.1 → XP_006513555.1  protein strawberry notch homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_006513555.1

    UniProtKB/Swiss-Prot
    Q3UE14, Q6P3A3, Q70X02, Q7TNB8
    UniProtKB/TrEMBL
    A0A1W2P7W8
    Related
    ENSMUSP00000151590.2, ENSMUST00000219260.2
    Conserved Domains (3) summary
    pfam13871
    Location:726 → 1004
    Helicase_C_4; C-terminal domain on Strawberry notch homolog
    pfam13872
    Location:212 → 500
    AAA_34; P-loop containing NTP hydrolase pore-1
    pfam17061
    Location:34 → 165
    PARM

  6. XM_036155740.1 → XP_036011633.1  protein strawberry notch homolog 2 isoform X8

    Conserved Domains (2) summary
    pfam13871
    Location:332 → 610
    Helicase_C_4; C-terminal domain on Strawberry notch homolog
    pfam13872
    Location:2 → 106
    AAA_34; P-loop containing NTP hydrolase pore-1

  7. XM_036155739.1 → XP_036011632.1  protein strawberry notch homolog 2 isoform X8

    Conserved Domains (2) summary
    pfam13871
    Location:332 → 610
    Helicase_C_4; C-terminal domain on Strawberry notch homolog
    pfam13872
    Location:2 → 106
    AAA_34; P-loop containing NTP hydrolase pore-1

  8. XM_036155741.1 → XP_036011634.1  protein strawberry notch homolog 2 isoform X9

    Conserved Domains (2) summary
    pfam13871
    Location:332 → 610
    Helicase_C_4; C-terminal domain on Strawberry notch homolog
    pfam13872
    Location:2 → 106
    AAA_34; P-loop containing NTP hydrolase pore-1

  9. XM_036155738.1 → XP_036011631.1  protein strawberry notch homolog 2 isoform X8

    Conserved Domains (2) summary
    pfam13871
    Location:332 → 610
    Helicase_C_4; C-terminal domain on Strawberry notch homolog
    pfam13872
    Location:2 → 106
    AAA_34; P-loop containing NTP hydrolase pore-1

  10. XM_006513493.1 → XP_006513556.1  protein strawberry notch homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_006513556.1

    UniProtKB/Swiss-Prot
    Q3UE14, Q6P3A3, Q70X02, Q7TNB8
    UniProtKB/TrEMBL
    A0A1W2P7W8
    Conserved Domains (3) summary
    pfam13871
    Location:726 → 1004
    Helicase_C_4; C-terminal domain on Strawberry notch homolog
    pfam13872
    Location:212 → 500
    AAA_34; P-loop containing NTP hydrolase pore-1
    pfam17061
    Location:34 → 165
    PARM

  11. XM_017313890.3 → XP_017169379.1  protein strawberry notch homolog 2 isoform X3

    UniProtKB/TrEMBL
    A0A1W2P7W8
    Conserved Domains (2) summary
    pfam13871
    Location:710 → 988
    Helicase_C_4; C-terminal domain on Strawberry notch homolog
    pfam13872
    Location:196 → 484
    AAA_34; P-loop containing NTP hydrolase pore-1

  12. XM_017313891.3 → XP_017169380.1  protein strawberry notch homolog 2 isoform X6

    UniProtKB/TrEMBL
    A0A1W2P7W8
    Conserved Domains (2) summary
    pfam13871
    Location:652 → 930
    Helicase_C_4; C-terminal domain on Strawberry notch homolog
    pfam13872
    Location:138 → 426
    AAA_34; P-loop containing NTP hydrolase pore-1

  13. XM_006513497.5 → XP_006513560.1  protein strawberry notch homolog 2 isoform X7

    UniProtKB/TrEMBL
    A0A1W2P7W8
    Conserved Domains (2) summary
    pfam13871
    Location:652 → 930
    Helicase_C_4; C-terminal domain on Strawberry notch homolog
    pfam13872
    Location:138 → 426
    AAA_34; P-loop containing NTP hydrolase pore-1

RNA

  1. XR_003948671.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TNB8.1 GenPept UniProtKB/Swiss-Prot:Q7TNB8

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