Wdr18 WD repeat domain 18 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wdr18provided by MGI
Official Full Name: WD repeat domain 18provided by MGI
Primary source: MGI:MGI:2158400
See related: Ensembl:ENSMUSG00000035754 AllianceGenome:MGI:2158400
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2310012I10Rik
Summary: Predicted to be involved in rRNA processing and regulation of DNA-dependent DNA replication initiation. Predicted to be located in nucleoplasm. Predicted to be part of Rix1 complex and nuclear pre-replicative complex. Orthologous to human WDR18 (WD repeat domain 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 32.7), adrenal adult (RPKM 28.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (79795989..79805081)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (79960152..79969247)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Recruitment of the protein complex 5FMC to Zbp-89, a zinc-finger transcription factor, affects its sumoylation status and transactivation potential.[5FMC]
Title: Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Jhu78 (e-PCR), detects polymorphism
- UniSTS:158727

AU044733 (e-PCR)
- UniSTS:160007

AW122032 (e-PCR)
- UniSTS:180073

NoName (e-PCR)
- UniSTS:236410

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in DNA-templated DNA replication	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in rRNA processing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of nuclear pre-replicative complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of rixosome complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WD repeat-containing protein 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175450.5 → NP_780659.2 WD repeat-containing protein 18

See identical proteins and their annotated locations for NP_780659.2

Status: VALIDATED

Source sequence(s)

AC151846

Consensus CDS

CCDS24000.1

UniProtKB/Swiss-Prot

Q4VBE8

Related

ENSMUSP00000041049.8, ENSMUST00000045247.9

Conserved Domains (4) summary

COG2319
Location:19 → 314

WD40; WD40 repeat [General function prediction only]

pfam14077
Location:383 → 429

WD40_alt; Alternative WD40 repeat motif

sd00039
Location:84 → 119

7WD40; WD40 repeat [structural motif]

cl02567
Location:22 → 297

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...