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Polrmt polymerase (RNA) mitochondrial (DNA directed) [ Mus musculus (house mouse) ]

Gene ID: 216151, updated on 21-Apr-2024

Summary

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Official Symbol
Polrmtprovided by MGI
Official Full Name
polymerase (RNA) mitochondrial (DNA directed)provided by MGI
Primary source
MGI:MGI:1915843
See related
Ensembl:ENSMUSG00000020329 AllianceGenome:MGI:1915843
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mtRPOL; 4932416K13; 1110018N15Rik
Summary
Enables sequence-specific DNA binding activity. Predicted to be involved in mitochondrial transcription. Located in mitochondrion. Part of protein-containing complex. Is expressed in early conceptus; limb mesenchyme; and secondary oocyte. Orthologous to human POLRMT (RNA polymerase mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 28.6), ovary adult (RPKM 26.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 39.72 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79571951..79582436, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79736125..79746604, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10624 Neighboring gene basigin Neighboring gene hyperpolarization-activated, cyclic nucleotide-gated K+ 2 Neighboring gene STARR-positive B cell enhancer ABC_E3897 Neighboring gene fibroblast growth factor 22 Neighboring gene ring finger protein 126 Neighboring gene STARR-positive B cell enhancer ABC_E899

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA. Kühl I, et al. Sci Adv, 2016 Aug. PMID 27532055, Free PMC Article
  2. POLRMT does not transcribe nuclear genes. Kühl I, et al. Nature, 2014 Oct 9. PMID 25297440
  3. TEFM regulates both transcription elongation and RNA processing in mitochondria. Jiang S, et al. EMBO Rep, 2019 Jun. PMID 31036713, Free PMC Article
  4. Transcription from the second heavy-strand promoter of human mtDNA is repressed by transcription factor A in vitro. Lodeiro MF, et al. Proc Natl Acad Sci U S A, 2012 Apr 24. PMID 22493245, Free PMC Article
  5. Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals. Kühl I, et al. Elife, 2017 Nov 14. PMID 29132502, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC118526

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA primase activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-directed 5'-3' RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-directed 5'-3' RNA polymerase activity ISO
Inferred from Sequence Orthology
more info
  
enables mitochondrial promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation at mitochondrial promoter ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
part_of mitochondrial DNA-directed RNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA-directed RNA polymerase, mitochondrial
Names
mitochondrial DNA-directed RNA polymerase
NP_001394721.1
NP_001394722.1
NP_001394723.1
NP_001394724.1
NP_001394725.1
NP_001394726.1
NP_001394727.1
NP_001394728.1
NP_766139.2
XP_030100878.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001407792.1 → NP_001394721.1  DNA-directed RNA polymerase, mitochondrial isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC151828

  2. NM_001407793.1 → NP_001394722.1  DNA-directed RNA polymerase, mitochondrial isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC151828

  3. NM_001407794.1 → NP_001394723.1  DNA-directed RNA polymerase, mitochondrial isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC151828

  4. NM_001407795.1 → NP_001394724.1  DNA-directed RNA polymerase, mitochondrial isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC151828
    UniProtKB/TrEMBL
    E9PWD9
    Related
    ENSMUSP00000124936.2, ENSMUST00000159016.8

  5. NM_001407796.1 → NP_001394725.1  DNA-directed RNA polymerase, mitochondrial isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC151828

  6. NM_001407797.1 → NP_001394726.1  DNA-directed RNA polymerase, mitochondrial isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC151828

  7. NM_001407798.1 → NP_001394727.1  DNA-directed RNA polymerase, mitochondrial isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC151828

  8. NM_001407799.1 → NP_001394728.1  DNA-directed RNA polymerase, mitochondrial isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC151828

  9. NM_172551.4 → NP_766139.2  DNA-directed RNA polymerase, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_766139.2

    Status: VALIDATED

    Source sequence(s)
    AC151828
    Consensus CDS
    CCDS23987.1
    UniProtKB/Swiss-Prot
    Q8BJE0, Q8BKF1
    UniProtKB/TrEMBL
    Q3U3J3, Q3V3C0
    Related
    ENSMUSP00000020580.7, ENSMUST00000020580.13
    Conserved Domains (4) summary
    PHA00452
    Location:437 → 1207
    PHA00452; T3/T7-like RNA polymerase
    sd00004
    Location:233 → 262
    PPR; PPR repeat [structural motif]
    pfam00940
    Location:802 → 1206
    RNA_pol; DNA-dependent RNA polymerase
    pfam14700
    Location:374 → 674
    RPOL_N; DNA-directed RNA polymerase N-terminal

RNA

  1. NR_176423.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC151828
    Related
    ENSMUST00000162694.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    79571951..79582436 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245018.2 → XP_030100878.1  DNA-directed RNA polymerase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q3V3C0
    Conserved Domains (3) summary
    sd00004
    Location:233 → 262
    PPR; PPR repeat [structural motif]
    pfam00940
    Location:802 → 1236
    RNA_pol; DNA-dependent RNA polymerase
    pfam14700
    Location:375 → 675
    RPOL_N; DNA-directed RNA polymerase N-terminal

RNA

  1. XR_003948668.2 RNA Sequence

    Related
    ENSMUST00000159082.8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BKF1.1 GenPept UniProtKB/Swiss-Prot:Q8BKF1

Gene LinkOut

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