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Ilvbl ilvB (bacterial acetolactate synthase)-like [ Mus musculus (house mouse) ]

Gene ID: 216136, updated on 5-Mar-2024

Summary

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Official Symbol
Ilvblprovided by MGI
Official Full Name
ilvB (bacterial acetolactate synthase)-likeprovided by MGI
Primary source
MGI:MGI:1351911
See related
Ensembl:ENSMUSG00000032763 AllianceGenome:MGI:1351911
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5830463I21
Summary
Predicted to enable acetolactate synthase activity and flavin adenine dinucleotide binding activity. Predicted to be involved in fatty acid alpha-oxidation; isoleucine biosynthetic process; and valine biosynthetic process. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of acetolactate synthase complex. Orthologous to human ILVBL (ilvB acetolactate synthase like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 37.8), duodenum adult (RPKM 32.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 39.72 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (78410178..78420336)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (78574344..78584502)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase 4a1 pseudogene Neighboring gene vomeronasal 2, receptor, pseudogene 92 Neighboring gene STARR-positive B cell enhancer ABC_E8865 Neighboring gene STARR-positive B cell enhancer ABC_E2945 Neighboring gene synapse defective 1, Rho GTPase, homolog 1 (C. elegans) Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:78057364-78057547 Neighboring gene predicted gene, 30346

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CHIP as a membrane-shuttling proteostasis sensor. Kopp Y, et al. Elife, 2017 Nov 1. PMID 29091030, Free PMC Article
  2. TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis. Yang Y, et al. EMBO J, 2022 Jul 18. PMID 35670107, Free PMC Article
  3. Perfect conserved linkage across the entire mouse chromosome 10 region homologous to human chromosome 21. Wiltshire T, et al. Genome Res, 1999 Dec. PMID 10613844, Free PMC Article
  4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetolactate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables thiamine pyrophosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid alpha-oxidation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in isoleucine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in valine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of acetolactate synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
2-hydroxyacyl-CoA lyase 2
Names
acetolactate synthase-like protein
ilvB-like protein
NP_001346230.1
NP_001346231.1
NP_001346232.1
NP_776112.1
XP_011241702.1
XP_030100875.1
XP_030100876.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359301.1 → NP_001346230.1  2-hydroxyacyl-CoA lyase 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC153887, AI842669, BC056459, BY231452
    UniProtKB/TrEMBL
    A0A1W2P8E1
    Conserved Domains (1) summary
    cl28198
    Location:63 → 596
    IlvB; Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme [Amino acid transport and metabolism, Coenzyme transport and metabolism]

  2. NM_001359302.1 → NP_001346231.1  2-hydroxyacyl-CoA lyase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI842669, AK133553, AK146075
    Consensus CDS
    CCDS23966.1
    UniProtKB/Swiss-Prot
    Q3UNZ4, Q3UZY5, Q8BU33
    UniProtKB/TrEMBL
    A0A1W2P8E1
    Related
    ENSMUSP00000151263.2, ENSMUST00000218885.2
    Conserved Domains (1) summary
    PRK05858
    Location:53 → 586
    PRK05858; acetolactate synthase

  3. NM_001359303.1 → NP_001346232.1  2-hydroxyacyl-CoA lyase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK133553, AK143918
    Consensus CDS
    CCDS88046.1
    Related
    ENSMUSP00000151480.2, ENSMUST00000218271.2
    Conserved Domains (1) summary
    PRK05858
    Location:53 → 361
    PRK05858; acetolactate synthase

  4. NM_173751.4 → NP_776112.1  2-hydroxyacyl-CoA lyase 2 isoform 2

    See identical proteins and their annotated locations for NP_776112.1

    Status: VALIDATED

    Source sequence(s)
    BC056459, CD768274, CK789563
    Consensus CDS
    CCDS23966.1
    UniProtKB/Swiss-Prot
    Q3UNZ4, Q3UZY5, Q8BU33
    UniProtKB/TrEMBL
    A0A1W2P8E1
    Related
    ENSMUSP00000101023.4, ENSMUST00000105384.5
    Conserved Domains (1) summary
    PRK05858
    Location:53 → 586
    PRK05858; acetolactate synthase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    78410178..78420336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243400.3 → XP_011241702.1  2-hydroxyacyl-CoA lyase 2 isoform X2

    See identical proteins and their annotated locations for XP_011241702.1

    UniProtKB/Swiss-Prot
    Q3UNZ4, Q3UZY5, Q8BU33
    UniProtKB/TrEMBL
    A0A1W2P8E1
    Conserved Domains (1) summary
    PRK05858
    Location:53 → 586
    PRK05858; acetolactate synthase

  2. XM_030245015.2 → XP_030100875.1  2-hydroxyacyl-CoA lyase 2 isoform X1

    UniProtKB/TrEMBL
    A0A1W2P8E1
    Conserved Domains (1) summary
    PRK05858
    Location:65 → 598
    PRK05858; acetolactate synthase

  3. XM_030245016.2 → XP_030100876.1  2-hydroxyacyl-CoA lyase 2 isoform X3

    Conserved Domains (1) summary
    PRK05858
    Location:65 → 373
    PRK05858; acetolactate synthase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BU33.1 GenPept UniProtKB/Swiss-Prot:Q8BU33

Gene LinkOut

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