Ube2d1 ubiquitin-conjugating enzyme E2D 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ube2d1provided by MGI
Official Full Name: ubiquitin-conjugating enzyme E2D 1provided by MGI
Primary source: MGI:MGI:2384911
See related: Ensembl:ENSMUSG00000019927 AllianceGenome:MGI:2384911
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: UBCH5
Summary: Enables ubiquitin conjugating enzyme activity. Acts upstream of or within positive regulation of protein polyubiquitination and protein polyubiquitination. Predicted to be located in cytoplasm. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in central nervous system; ganglia; and urethra. Orthologous to human UBE2D1 (ubiquitin conjugating enzyme E2 D1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E18 (RPKM 61.3), whole brain E14.5 (RPKM 59.8) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B5.3; 10 36.85 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (71090810..71121048, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (71254980..71285384, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Its gene expression is inhibited through p53 dependent apoptosis, which is induced by cadmium exposure.(review)
Title: [Cadmium induces p53-dependent apoptosis through the inhibition of Ube2d family gene expression].
significantly elevated levels of SFT/UbcH5A mRNA in the neonatal mouse and its localization to choroid plexus suggest that this factor may contribute to the rapid rate of brain iron uptake that occurs in the early postnatal period
Title: Developmental, regional, and cellular expression of SFT/UbcH5A and DMT1 mRNA in brain.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin conjugating enzyme activity	ISO Inferred from Sequence Orthology more info	PubMed
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein polyubiquitination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquitin-conjugating enzyme E2 D1

Names: (E3-independent) E2 ubiquitin-conjugating enzyme D1; E2 ubiquitin-conjugating enzyme D1; E2(17)KB 1; ubiquitin carrier protein D1; ubiquitin-conjugating enzyme E2(17)KB 1; ubiquitin-conjugating enzyme E2-17 kDa 1; ubiquitin-conjugating enzyme E2D 1, UBC4/5 homolog; ubiquitin-protein ligase D1

NP_001408209.1

EC 2.3.2.23

EC 2.3.2.24

NP_001408210.1

EC 2.3.2.23

EC 2.3.2.24

NP_001408212.1

EC 2.3.2.23

EC 2.3.2.24

NP_001408213.1

EC 2.3.2.23

EC 2.3.2.24

NP_663395.1

EC 2.3.2.23

EC 2.3.2.24

XP_006513541.1

EC 2.3.2.23

EC 2.3.2.24

XP_006513542.1

EC 2.3.2.23

EC 2.3.2.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001421280.1 → NP_001408209.1 ubiquitin-conjugating enzyme E2 D1 isoform 2

Status: VALIDATED

Source sequence(s)

AC153509
NM_001421281.1 → NP_001408210.1 ubiquitin-conjugating enzyme E2 D1 isoform 3

Status: VALIDATED

Source sequence(s)

AC153509
NM_001421283.1 → NP_001408212.1 ubiquitin-conjugating enzyme E2 D1 isoform 4

Status: VALIDATED

Source sequence(s)

AC153509
NM_001421284.1 → NP_001408213.1 ubiquitin-conjugating enzyme E2 D1 isoform 5

Status: VALIDATED

Source sequence(s)

AC153509
NM_145420.3 → NP_663395.1 ubiquitin-conjugating enzyme E2 D1 isoform 1

See identical proteins and their annotated locations for NP_663395.1

Status: VALIDATED

Source sequence(s)

AC153509

Consensus CDS

CCDS35933.1

UniProtKB/Swiss-Prot

P61080

UniProtKB/TrEMBL

Q3UFQ4

Related

ENSMUSP00000020085.7, ENSMUST00000020085.7

Conserved Domains (1) summary

cl00154
Location:1 → 146

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RNA

NR_185290.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153509

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

71090810..71121048 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513479.2 → XP_006513542.1 ubiquitin-conjugating enzyme E2 D1 isoform X2

Conserved Domains (1) summary

cl00154
Location:19 → 133

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
XM_006513478.2 → XP_006513541.1 ubiquitin-conjugating enzyme E2 D1 isoform X1

Conserved Domains (1) summary

cl00154
Location:19 → 159

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...