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Mfsd4b5 major facilitator superfamily domain containing 4B5 [ Mus musculus (house mouse) ]

Gene ID: 215928, updated on 8-Feb-2024

Summary

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Official Symbol
Mfsd4b5provided by MGI
Official Full Name
major facilitator superfamily domain containing 4B5provided by MGI
Primary source
MGI:MGI:2446139
See related
Ensembl:ENSMUSG00000038528 AllianceGenome:MGI:2446139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Naglt1c
Summary
Predicted to enable glucose transmembrane transporter activity. Orthologous to human MFSD4B (major facilitator superfamily domain containing 4B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 30.0) and placenta adult (RPKM 3.9) See more
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Genomic context

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Location:
10 B1; 10 21.37 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (39834057..39862642, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (39958061..39986646, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily domain containing 4B2 Neighboring gene major facilitator superfamily domain containing 4B3, pseudogene Neighboring gene neutrophil immunoglobulin-like receptor 1 Neighboring gene STARR-positive B cell enhancer ABC_E5125 Neighboring gene STARR-seq mESC enhancer starr_26408 Neighboring gene major facilitator superfamily domain containing 4B1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 10 Neighboring gene STARR-seq mESC enhancer starr_26410 Neighboring gene predicted gene, 25613

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
  5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glucose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucose transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
sodium-dependent glucose transporter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001489.3 → NP_001001489.1  sodium-dependent glucose transporter 1 isoform b

    See identical proteins and their annotated locations for NP_001001489.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the 3' region, resulting in a novel 3' coding region and shorter 3' UTR, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC168279, AK085266
    Consensus CDS
    CCDS23791.1
    UniProtKB/TrEMBL
    Q8C3P4, Q8VC53
    Related
    ENSMUSP00000130944.2, ENSMUST00000164566.8

  2. NM_001113385.1 → NP_001106856.1  sodium-dependent glucose transporter 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC168279, AI527856, AK085266
    Consensus CDS
    CCDS48542.1
    UniProtKB/TrEMBL
    E9PYY6
    Related
    ENSMUSP00000126439.2, ENSMUST00000170579.9
    Conserved Domains (2) summary
    cd06174
    Location:38 → 445
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:41 → 408
    MFS_1; Major Facilitator Superfamily

  3. NM_001113388.2 → NP_001106859.1  sodium-dependent glucose transporter 1 isoform c

    See identical proteins and their annotated locations for NP_001106859.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 3' terminal exon, compared to variant 1. The encoded isoform (c) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK085266, AK165493
    Consensus CDS
    CCDS48541.1
    UniProtKB/TrEMBL
    Q3TN71, Q8VC53
    Related
    ENSMUSP00000073304.6, ENSMUST00000073618.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    39834057..39862642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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