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Arfgef3 ARFGEF family member 3 [ Mus musculus (house mouse) ]

Gene ID: 215821, updated on 5-Mar-2024

Summary

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Official Symbol
Arfgef3provided by MGI
Official Full Name
ARFGEF family member 3provided by MGI
Primary source
MGI:MGI:106387
See related
Ensembl:ENSMUSG00000019852 AllianceGenome:MGI:106387
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BIG3; mKIAA1244; 9630004D11; D10Bwg1379e; B930094H20Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in actin cytoskeleton organization. Predicted to be located in cytoplasmic vesicle and membrane. Predicted to be integral component of membrane. Is expressed in central nervous system; dorsal root ganglion; and sensory organ. Orthologous to human ARFGEF3 (ARFGEF family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 3.5), colon adult (RPKM 3.2) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Arfgef3 in Genome Data Viewer
Location:
10 A3; 10 7.79 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (18463759..18619506, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (18588011..18743758, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene NHS like 1 Neighboring gene STARR-seq mESC enhancer starr_25897 Neighboring gene family with sequence similarity 54, member A pseudogene Neighboring gene STARR-seq mESC enhancer starr_25901 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:18228522-18228723 Neighboring gene STARR-seq mESC enhancer starr_25912 Neighboring gene heme binding protein 2 Neighboring gene STARR-seq mESC enhancer starr_25915 Neighboring gene STARR-seq mESC enhancer starr_25916 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:18384699-18384900 Neighboring gene predicted gene, 32926 Neighboring gene STARR-seq mESC enhancer starr_25918 Neighboring gene RIKEN cDNA 4930444F02 gene Neighboring gene predicted gene 4922

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Increased biogenesis of glucagon-containing secretory granules and glucagon secretion in BIG3-knockout mice. Li H, et al. Mol Metab, 2015 Mar. PMID 25737957, Free PMC Article
  2. Brefeldin A-inhibited guanine nucleotide exchange protein 3 is localized in lysosomes and regulates GABA signaling in hippocampal neurons. Liu T, et al. J Neurochem, 2016 Dec. PMID 27696409
  3. Detection of insulin granule exocytosis by an electrophysiology method with high temporal resolution reveals enlarged insulin granule pool in BIG3-knockout mice. Liu T, et al. Am J Physiol Endocrinol Metab, 2014 Oct 1. PMID 25139048
  4. BIG3 inhibits insulin granule biogenesis and insulin secretion. Li H, et al. EMBO Rep, 2014 Jun. PMID 24711543, Free PMC Article
  5. Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells. Zhang M, et al. Mol Cell Proteomics, 2014 Nov. PMID 25044020, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
brefeldin A-inhibited guanine nucleotide-exchange protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033258.4 → NP_001028430.1  brefeldin A-inhibited guanine nucleotide-exchange protein 3

    See identical proteins and their annotated locations for NP_001028430.1

    Status: PROVISIONAL

    Source sequence(s)
    AC153558, AC153561
    Consensus CDS
    CCDS23712.1
    UniProtKB/Swiss-Prot
    Q3UGY8, Q80TH0
    Related
    ENSMUSP00000149210.2, ENSMUST00000215836.2
    Conserved Domains (3) summary
    smart00222
    Location:582 → 794
    Sec7; Sec7 domain
    pfam09324
    Location:1241 → 1298
    DUF1981; Domain of unknown function (DUF1981)
    pfam16213
    Location:16 → 121
    DCB; dimerization and cyclophilin-binding domain of Mon2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    18463759..18619506 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UGY8.1 GenPept UniProtKB/Swiss-Prot:Q3UGY8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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