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Nhsl1 NHS like 1 [ Mus musculus (house mouse) ]

Gene ID: 215819, updated on 21-Apr-2024

Summary

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Official Symbol
Nhsl1provided by MGI
Official Full Name
NHS like 1provided by MGI
Primary source
MGI:MGI:106390
See related
Ensembl:ENSMUSG00000039835 AllianceGenome:MGI:106390
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1357; A730096F01; D10Bwg0940e; 5730409E15Rik; A630035H13Rik
Summary
Predicted to be involved in cell differentiation. Is expressed in several structures, including alimentary system; brain; eye; male reproductive gland or organ; and trachea. Orthologous to human NHSL1 (NHS like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 6.3), large intestine adult (RPKM 6.0) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 A3; 10 7.65 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (18193419..18409640)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (18317665..18533892)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8325 Neighboring gene coiled-coil domain containing 28A Neighboring gene predicted gene 10827 Neighboring gene STARR-seq mESC enhancer starr_25897 Neighboring gene predicted gene, 53616 Neighboring gene family with sequence similarity 54, member A pseudogene Neighboring gene STARR-seq mESC enhancer starr_25901 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:18228522-18228723 Neighboring gene STARR-seq mESC enhancer starr_25912 Neighboring gene heme binding protein 2 Neighboring gene ARFGEF family member 3 Neighboring gene STARR-seq mESC enhancer starr_25915 Neighboring gene STARR-seq mESC enhancer starr_25916 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:18384699-18384900 Neighboring gene predicted gene, 32926

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
  2. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article
  3. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1357

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NHS-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163592.2 → NP_001157064.1  NHS-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153561
    Consensus CDS
    CCDS48508.1
    UniProtKB/Swiss-Prot
    Q8CAF4
    Related
    ENSMUSP00000097631.4, ENSMUST00000100054.4
    Conserved Domains (1) summary
    pfam15273
    Location:255 → 879
    NHS; NHS-like

  2. NM_001405956.1 → NP_001392885.1  NHS-like protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC153561, AC153562
    UniProtKB/TrEMBL
    A0A140LIZ7
    Related
    ENSMUSP00000147021.2, ENSMUST00000207038.2

  3. NM_001405957.1 → NP_001392886.1  NHS-like protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC153561

  4. NM_001405958.1 → NP_001392887.1  NHS-like protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC153561

  5. NM_173390.4 → NP_775566.3  NHS-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_775566.3

    Status: VALIDATED

    Source sequence(s)
    AC153560, AC153561
    Consensus CDS
    CCDS35853.1
    UniProtKB/Swiss-Prot
    Q5DTY4, Q6P6Y7, Q8C8Z7, Q8CAF4, Q8K0R2, Q91YY6, Q9CYM2
    Related
    ENSMUSP00000040799.8, ENSMUST00000037341.14
    Conserved Domains (1) summary
    pfam15273
    Location:259 → 883
    NHS; NHS-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    18193419..18409640
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245007.2 → XP_030100867.1  NHS-like protein 1 isoform X11

    Conserved Domains (2) summary
    PRK11901
    Location:955 → 1144
    PRK11901; hypothetical protein; Reviewed
    pfam15273
    Location:1 → 604
    NHS; NHS-like

  2. XM_030245006.2 → XP_030100866.1  NHS-like protein 1 isoform X11

    Conserved Domains (2) summary
    PRK11901
    Location:955 → 1144
    PRK11901; hypothetical protein; Reviewed
    pfam15273
    Location:1 → 604
    NHS; NHS-like

  3. XM_006512686.5 → XP_006512749.1  NHS-like protein 1 isoform X2

    Conserved Domains (2) summary
    PRK11901
    Location:1308 → 1497
    PRK11901; hypothetical protein; Reviewed
    pfam15273
    Location:333 → 957
    NHS; NHS-like

  4. XM_006512691.5 → XP_006512754.1  NHS-like protein 1 isoform X11

    Conserved Domains (2) summary
    PRK11901
    Location:955 → 1144
    PRK11901; hypothetical protein; Reviewed
    pfam15273
    Location:1 → 604
    NHS; NHS-like

  5. XM_006512687.5 → XP_006512750.1  NHS-like protein 1 isoform X4

    Conserved Domains (2) summary
    PHA03307
    Location:1198 → 1548
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15273
    Location:303 → 927
    NHS; NHS-like

  6. XM_036155732.1 → XP_036011625.1  NHS-like protein 1 isoform X1

    Conserved Domains (2) summary
    PRK11901
    Location:1326 → 1515
    PRK11901; hypothetical protein; Reviewed
    pfam15273
    Location:350 → 975
    NHS; NHS-like

  7. XM_036155733.1 → XP_036011626.1  NHS-like protein 1 isoform X3

    Conserved Domains (2) summary
    PRK11901
    Location:1282 → 1471
    PRK11901; hypothetical protein; Reviewed
    pfam15273
    Location:306 → 931
    NHS; NHS-like

  8. XM_006512689.5 → XP_006512752.1  NHS-like protein 1 isoform X6

    Conserved Domains (2) summary
    PHA03307
    Location:1152 → 1502
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15273
    Location:257 → 881
    NHS; NHS-like

  9. XM_030245003.2 → XP_030100863.1  NHS-like protein 1 isoform X8

    Conserved Domains (2) summary
    PRK11901
    Location:1188 → 1377
    PRK11901; hypothetical protein; Reviewed
    pfam15273
    Location:213 → 837
    NHS; NHS-like

  10. XM_030245004.2 → XP_030100864.1  NHS-like protein 1 isoform X9

    Conserved Domains (2) summary
    PRK11901
    Location:1186 → 1375
    PRK11901; hypothetical protein; Reviewed
    pfam15273
    Location:211 → 835
    NHS; NHS-like

  11. XM_030245009.2 → XP_030100869.1  NHS-like protein 1 isoform X11

    Conserved Domains (2) summary
    PRK11901
    Location:955 → 1144
    PRK11901; hypothetical protein; Reviewed
    pfam15273
    Location:1 → 604
    NHS; NHS-like

  12. XM_030245008.2 → XP_030100868.1  NHS-like protein 1 isoform X11

    Conserved Domains (2) summary
    PRK11901
    Location:955 → 1144
    PRK11901; hypothetical protein; Reviewed
    pfam15273
    Location:1 → 604
    NHS; NHS-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CAF4.3 GenPept UniProtKB/Swiss-Prot:Q8CAF4

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