Adgrg6 adhesion G protein-coupled receptor G6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adgrg6provided by MGI
Official Full Name: adhesion G protein-coupled receptor G6provided by MGI
Primary source: MGI:MGI:1916151
See related: Ensembl:ENSMUSG00000039116 AllianceGenome:MGI:1916151
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DREG; Gm222; Gpr126; 1190004A11Rik
Summary: Enables laminin binding activity. Involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; heart trabecula formation; and myelination in peripheral nervous system. Predicted to be located in cell surface; cytoplasm; and plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including heart; lung; otocyst; paraxial mesenchyme; and spleen. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human ADGRG6 (adhesion G protein-coupled receptor G6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in placenta adult (RPKM 10.1), lung adult (RPKM 8.1) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A2; 10 5.43 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (14278327..14421467, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (14402583..14545723, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adhesion GPCR Gpr126 (Adgrg6) Expression Profiling in Zebrafish, Mouse, and Human Kidney.
Title: Adhesion GPCR Gpr126 (Adgrg6) Expression Profiling in Zebrafish, Mouse, and Human Kidney.
An adhesion G protein-coupled receptor is required in cartilaginous and dense connective tissues to maintain spine alignment.
Title: An adhesion G protein-coupled receptor is required in cartilaginous and dense connective tissues to maintain spine alignment.
Gpr126/Adgrg6 contributes to the terminal Schwann cell response at the neuromuscular junction following peripheral nerve injury.
Title: Gpr126/Adgrg6 contributes to the terminal Schwann cell response at the neuromuscular junction following peripheral nerve injury.
These findings establish ADGRG6 and STAT3 as novel regulators of intervertebral disc endplate and growth plate integrity in the mouse, and implicate ADGRG6/STAT3 signaling as promising therapeutic targets for endplate-oriented disc degeneration
Title: Dysregulation of STAT3 signaling is associated with endplate-oriented herniations of the intervertebral disc in Adgrg6 mutant mice.
we show that the adhesion class G protein-coupled receptor (GPCR) Gpr126/Adgrg6 is required for remyelination, macrophage recruitment, and axon regeneration following nerve
Title: Gpr126/Adgrg6 Has Schwann Cell Autonomous and Nonautonomous Functions in Peripheral Nerve Injury and Repair.
PrP(C) promotes myelin homeostasis through flexible tail-mediated Gpr126 agonism
Title: The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6.
Together, these data uncover Gpr126 as a genetic cause for the pathogenesis of Adolescent idiopathic scoliosis (AIS) and pectus excavatum in a mouse model.
Title: Gpr126/Adgrg6 deletion in cartilage models idiopathic scoliosis and pectus excavatum in mice.
GPR126 modulates both physiological and pathological angiogenesis through VEGF signaling
Title: GPR126 protein regulates developmental and pathological angiogenesis through modulation of VEGFR2 receptor signaling.
a model in which the NTF of Gpr126, in contrast to the C-terminal fragment, plays an important role in heart development.
Title: Organ-specific function of adhesion G protein-coupled receptor GPR126 is domain-dependent.
Analysis shows that Gpr126 is required for Schwann cell myelination in mammals, and defines new roles for Gpr126 in axonal sorting, formation of mature non-myelinating Schwann cells and organization of the perineurium.
Title: Gpr126 is essential for peripheral nerve development and myelination in mammals.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (6) 1 citation

General gene information

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Markers

Gpr126 (e-PCR), detects polymorphism
- UniSTS:472874

Gpr126 (e-PCR), detects polymorphism
- UniSTS:472875

AW045736 (e-PCR)
- UniSTS:180011

AI449247 (e-PCR)
- UniSTS:159953

RH47174 (e-PCR)
- UniSTS:34792

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables laminin binding	IBA Inferred from Biological aspect of Ancestor more info
enables laminin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Schwann cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in heart trabecula formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart trabecula formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myelination	ISO Inferred from Sequence Orthology more info
involved_in myelination in peripheral nervous system	IBA Inferred from Biological aspect of Ancestor more info
involved_in myelination in peripheral nervous system	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: adhesion G-protein coupled receptor G6

Names: G protein coupled receptor Gpr126; G-protein coupled receptor 126; developmentally regulated G-protein-coupled receptor; probable G-protein coupled receptor 126

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002268.3 → NP_001002268.1 adhesion G-protein coupled receptor G6 precursor

See identical proteins and their annotated locations for NP_001002268.1

Status: VALIDATED

Source sequence(s)

AB183545, AC118202

Consensus CDS

CCDS35848.1

UniProtKB/Swiss-Prot

Q6F3F9, Q811E4

UniProtKB/TrEMBL

A0A140LIH4

Related

ENSMUSP00000043055.5, ENSMUST00000041168.6

Conserved Domains (5) summary

smart00303
Location:771 → 822

GPS; G-protein-coupled receptor proteolytic site domain

cd00041
Location:38 → 146

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cl02422
Location:505 → 550

HRM; Hormone receptor domain

cl21561
Location:833 → 1080

7tm_4; Olfactory receptor

cl22861
Location:178 → 337

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

14278327..14421467 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245001.1 → XP_030100861.1 adhesion G-protein coupled receptor G6 isoform X5

UniProtKB/TrEMBL

A0A140LIH4, A0A571BEJ4

Related

ENSMUSP00000158717.2, ENSMUST00000238680.2

Conserved Domains (6) summary

cd00041
Location:38 → 146

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd14964
Location:833 → 858

7tm_GPCRs; TM helix 1 [structural motif]

pfam01825
Location:771 → 816

GPS; GPCR proteolysis site, GPS, motif

cl02422
Location:505 → 550

HRM; Hormone receptor domain

cl22861
Location:178 → 337

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl28897
Location:831 → 1099

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006512679.4 → XP_006512742.1 adhesion G-protein coupled receptor G6 isoform X2

UniProtKB/TrEMBL

A0A140LIH4

Conserved Domains (6) summary

cd00041
Location:38 → 146

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd14964
Location:861 → 886

7tm_GPCRs; TM helix 1 [structural motif]

pfam01825
Location:799 → 844

GPS; GPCR proteolysis site, GPS, motif

cl02422
Location:533 → 578

HRM; Hormone receptor domain

cl22861
Location:178 → 337

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl28897
Location:859 → 1127

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006512681.4 → XP_006512744.1 adhesion G-protein coupled receptor G6 isoform X4

UniProtKB/TrEMBL

A0A140LIH4

Conserved Domains (6) summary

cd00041
Location:48 → 156

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd14964
Location:843 → 868

7tm_GPCRs; TM helix 1 [structural motif]

pfam01825
Location:781 → 826

GPS; GPCR proteolysis site, GPS, motif

cl02422
Location:515 → 560

HRM; Hormone receptor domain

cl22861
Location:188 → 347

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl28897
Location:841 → 1109

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_036155731.1 → XP_036011624.1 adhesion G-protein coupled receptor G6 isoform X8

UniProtKB/TrEMBL

A0A140LIH4

Conserved Domains (5) summary

cd00041
Location:48 → 156

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

pfam01825
Location:781 → 826

GPS; GPCR proteolysis site, GPS, motif

cd14964
Location:843 → 868

7tm_GPCRs; TM helix 1 [structural motif]

cl22861
Location:188 → 347

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl28897
Location:841 → 1109

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006512678.4 → XP_006512741.1 adhesion G-protein coupled receptor G6 isoform X1

UniProtKB/TrEMBL

A0A140LIH4

Conserved Domains (6) summary

cd00041
Location:48 → 156

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd14964
Location:871 → 896

7tm_GPCRs; TM helix 1 [structural motif]

pfam01825
Location:809 → 854

GPS; GPCR proteolysis site, GPS, motif

cl02422
Location:543 → 588

HRM; Hormone receptor domain

cl22861
Location:188 → 347

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl28897
Location:869 → 1137

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_017313881.2 → XP_017169370.1 adhesion G-protein coupled receptor G6 isoform X7

UniProtKB/TrEMBL

A0A140LIH4

Conserved Domains (5) summary

cd00041
Location:48 → 156

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd14964
Location:871 → 896

7tm_GPCRs; TM helix 1 [structural motif]

pfam01825
Location:809 → 854

GPS; GPCR proteolysis site, GPS, motif

cl22861
Location:188 → 347

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl28897
Location:869 → 1137

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006512680.3 → XP_006512743.1 adhesion G-protein coupled receptor G6 isoform X3

UniProtKB/TrEMBL

A0A140LIH4

Conserved Domains (6) summary

cd00041
Location:37 → 145

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd14964
Location:860 → 885

7tm_GPCRs; TM helix 1 [structural motif]

pfam01825
Location:798 → 843

GPS; GPCR proteolysis site, GPS, motif

cl02422
Location:532 → 577

HRM; Hormone receptor domain

cl22861
Location:177 → 336

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl28897
Location:858 → 1126

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006512682.5 → XP_006512745.1 adhesion G-protein coupled receptor G6 isoform X6

UniProtKB/TrEMBL

A0A140LIH4

Related

ENSMUSP00000146821.2, ENSMUST00000208429.3

Conserved Domains (5) summary

cd00041
Location:48 → 156

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd14964
Location:871 → 896

7tm_GPCRs; TM helix 1 [structural motif]

pfam01825
Location:809 → 854

GPS; GPCR proteolysis site, GPS, motif

cl22861
Location:188 → 347

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl28897
Location:869 → 1137

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily