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Adgb androglobin [ Mus musculus (house mouse) ]

Gene ID: 215772, updated on 21-Apr-2024

Summary

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Official Symbol
Adgbprovided by MGI
Official Full Name
androglobinprovided by MGI
Primary source
MGI:MGI:3605549
See related
Ensembl:ENSMUSG00000050994 AllianceGenome:MGI:3605549
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9130014G24Rik
Summary
Predicted to enable calcium-dependent cysteine-type endopeptidase activity; heme binding activity; and oxygen binding activity. Predicted to be involved in proteolysis. Is expressed in lung. Orthologous to human ADGB (androglobin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 5.3), liver E18 (RPKM 0.6) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 A1; 10 3.44 cM
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (10211447..10350837, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (10335703..10475093, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930598N05 gene Neighboring gene predicted gene, 31904 Neighboring gene STARR-seq mESC enhancer starr_25741 Neighboring gene STARR-positive B cell enhancer mm9_chr10:10055172-10055473 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_25742 Neighboring gene STARR-seq mESC enhancer starr_25744 Neighboring gene STARR-seq mESC enhancer starr_25746 Neighboring gene RAB32, member RAS oncogene family Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ADGB variants cause asthenozoospermia and male infertility. Qu R, et al. Hum Genet, 2023 Jun. PMID 36995441
  2. Androglobin: a chimeric globin in metazoans that is preferentially expressed in Mammalian testes. Hoogewijs D, et al. Mol Biol Evol, 2012 Apr. PMID 22115833, Free PMC Article
  3. Androglobin, a chimeric mammalian globin, is required for male fertility. Keppner A, et al. Elife, 2022 Jun 14. PMID 35700329, Free PMC Article
  4. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ADGB variants cause asthenozoospermia and male infertility.
    Title: ADGB variants cause asthenozoospermia and male infertility.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium-dependent cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables oxygen binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
located_in sperm annulus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm midpiece IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
androglobin
Names
calpain-7-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127353.4 → NP_001120825.3  androglobin

    Status: VALIDATED

    Source sequence(s)
    AC153567, AC159380
    UniProtKB/TrEMBL
    J3QMP3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    10211447..10350837 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243163.3 → XP_011241465.1  androglobin isoform X5

    UniProtKB/TrEMBL
    A0A140LI36
    Conserved Domains (2) summary
    PTZ00121
    Location:1284 → 1651
    PTZ00121; MAEBL; Provisional
    cl00051
    Location:200 → 307
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

  2. XM_017313876.2 → XP_017169365.1  androglobin isoform X4

    UniProtKB/Swiss-Prot
    G3UZ78, Q8C5C7
    Conserved Domains (2) summary
    PTZ00121
    Location:1310 → 1677
    PTZ00121; MAEBL; Provisional
    cl00051
    Location:200 → 307
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

  3. XM_030244999.1 → XP_030100859.1  androglobin isoform X7

    UniProtKB/Swiss-Prot
    G3UZ78, Q8C5C7
    Conserved Domains (2) summary
    pfam09731
    Location:1329 → 1639
    Mitofilin; Mitochondrial inner membrane protein
    cl00051
    Location:200 → 307
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

  4. XM_011243160.3 → XP_011241462.1  androglobin isoform X2

    UniProtKB/Swiss-Prot
    G3UZ78, Q8C5C7
    Conserved Domains (2) summary
    PTZ00121
    Location:1328 → 1695
    PTZ00121; MAEBL; Provisional
    cl00051
    Location:200 → 307
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

  5. XM_017313877.2 → XP_017169366.1  androglobin isoform X6

    UniProtKB/Swiss-Prot
    G3UZ78, Q8C5C7
    Conserved Domains (2) summary
    PTZ00121
    Location:1332 → 1640
    PTZ00121; MAEBL; Provisional
    cl00051
    Location:200 → 307
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

  6. XM_017313875.2 → XP_017169364.1  androglobin isoform X1

    UniProtKB/Swiss-Prot
    G3UZ78, Q8C5C7
    Conserved Domains (2) summary
    PTZ00121
    Location:1329 → 1696
    PTZ00121; MAEBL; Provisional
    cl00051
    Location:200 → 307
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

  7. XM_017313879.3 → XP_017169368.1  androglobin isoform X10

    UniProtKB/Swiss-Prot
    G3UZ78, Q8C5C7
    Related
    ENSMUSP00000134378.2, ENSMUST00000172530.8
    Conserved Domains (2) summary
    PTZ00121
    Location:1296 → 1663
    PTZ00121; MAEBL; Provisional
    cl00051
    Location:186 → 293
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

  8. XM_006512658.5 → XP_006512721.1  androglobin isoform X3

    UniProtKB/Swiss-Prot
    G3UZ78, Q8C5C7
    Conserved Domains (2) summary
    PTZ00121
    Location:1315 → 1682
    PTZ00121; MAEBL; Provisional
    cl00051
    Location:186 → 293
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

  9. XM_006512663.4 → XP_006512726.1  androglobin isoform X8

    Conserved Domains (1) summary
    PTZ00121
    Location:896 → 1263
    PTZ00121; MAEBL; Provisional

  10. XM_017313878.2 → XP_017169367.1  androglobin isoform X9

    Conserved Domains (1) summary
    cl00051
    Location:200 → 307
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172547.3: Suppressed sequence

    Description
    NM_172547.3: This RefSeq was temporarily suppressed because the CDS was partial.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G3UZ78.1 GenPept UniProtKB/Swiss-Prot:G3UZ78

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