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Miga1 mitoguardin 1 [ Mus musculus (house mouse) ]

Gene ID: 215708, updated on 21-Apr-2024

Summary

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Official Symbol
Miga1provided by MGI
Official Full Name
mitoguardin 1provided by MGI
Primary source
MGI:MGI:1924567
See related
Ensembl:ENSMUSG00000054942 AllianceGenome:MGI:1924567
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mita1; Fam73a; A930038D06; C030011O14Rik
Summary
Predicted to enable protein heterodimerization activity and protein homodimerization activity. Involved in mitochondrial fusion. Predicted to be located in mitochondrion. Predicted to be integral component of plasma membrane. Is expressed in brain; metanephros; spinal cord; and testis. Orthologous to human MIGA1 (mitoguardin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 11.0), cortex adult (RPKM 9.9) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 H3; 3 77.1 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (151979096..152046073, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (152273459..152340436, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr3:151922476-151922776 Neighboring gene nexilin Neighboring gene predicted gene, 31999 Neighboring gene VISTA enhancer mm72 Neighboring gene ubiquitin specific peptidase 33 Neighboring gene zinc finger, ZZ domain containing 3 Neighboring gene predicted gene, 57837

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases. Qiu Z, et al. Nucleic Acids Res, 2013 Jun. PMID 23630316, Free PMC Article
  2. Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability. Gao Z, et al. Nat Commun, 2017 Nov 27. PMID 29180626, Free PMC Article
  3. Mitoguardin-1 and -2 promote maturation and the developmental potential of mouse oocytes by maintaining mitochondrial dynamics and functions. Liu XM, et al. Oncotarget, 2016 Jan 12. PMID 26716412, Free PMC Article
  4. Mitochondrial Function Regulated by Mitoguardin-1/2 Is Crucial for Ovarian Endocrine Functions and Ovulation. Liu XM, et al. Endocrinology, 2017 Nov 1. PMID 28938432
  5. Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis. Zhang Y, et al. Mol Cell, 2016 Jan 7. PMID 26711011

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The ovarian phenotypes of these mice suggested that MIGA1/2 proteins play an important role in ovulation and ovarian steroidogenesis. In vivo and in vitro analyses of Miga1/2-knockout granulosa cells showed severe defects in luteinization and steroidogenesis and disordered mitochondrial morphology and function in response to gonadotropins.
    Title: Mitochondrial Function Regulated by Mitoguardin-1/2 Is Crucial for Ovarian Endocrine Functions and Ovulation.
  2. Data indicate that mitoguardin (Miga) knoskout Miga1/2-/- females show greatly reduced quality of oocytes and early embryos and are subfertile.
    Title: Mitoguardin-1 and -2 promote maturation and the developmental potential of mouse oocytes by maintaining mitochondrial dynamics and functions.
  3. Propose that MIGA1/2 proteins promote mitochondrial fusion by regulating mitochondrial phospholipid metabolism via MitoPLD.
    Title: Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (5)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitochondrial fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial fusion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitoguardin 1
Names
family with sequence similarity 73, member A
protein FAM73A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162375.1 → NP_001155847.1  mitoguardin 1 isoform 2

    See identical proteins and their annotated locations for NP_001155847.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two exons in the coding region compared to variant 1. The encoded isoform (2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC123075, AK045347, AK085017
    Consensus CDS
    CCDS51096.1
    UniProtKB/Swiss-Prot
    Q4QQM5
    Related
    ENSMUSP00000068261.7, ENSMUST00000068243.11
    Conserved Domains (1) summary
    pfam10265
    Location:27 → 507
    DUF2217; Uncharacterized conserved protein (DUF2217)

  2. NM_174868.4 → NP_777357.2  mitoguardin 1 isoform 1

    See identical proteins and their annotated locations for NP_777357.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC123075, AK085017, BC098205
    Consensus CDS
    CCDS17916.1
    UniProtKB/Swiss-Prot
    Q4QQM5, Q8BR91, Q8C3S6, Q8C8P4
    UniProtKB/TrEMBL
    B2RRB9
    Related
    ENSMUSP00000072836.7, ENSMUST00000073089.13
    Conserved Domains (1) summary
    pfam10265
    Location:27 → 571
    DUF2217; Uncharacterized conserved protein (DUF2217)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    151979096..152046073 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163015.1 → XP_036018908.1  mitoguardin 1 isoform X3

    Conserved Domains (1) summary
    pfam10265
    Location:2 → 306
    Miga; Mitoguardin

  2. XM_011240070.4 → XP_011238372.1  mitoguardin 1 isoform X1

    Related
    ENSMUSP00000143238.2, ENSMUST00000199334.5
    Conserved Domains (1) summary
    pfam10265
    Location:27 → 489
    Miga; Mitoguardin

  3. XM_036163016.1 → XP_036018909.1  mitoguardin 1 isoform X4

    Conserved Domains (1) summary
    pfam10265
    Location:27 → 301
    Miga; Mitoguardin

  4. XM_036163014.1 → XP_036018907.1  mitoguardin 1 isoform X2

    Conserved Domains (1) summary
    pfam10265
    Location:27 → 339
    Miga; Mitoguardin

RNA

  1. XR_001783676.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4QQM5.1 GenPept UniProtKB/Swiss-Prot:Q4QQM5

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